当前位置： SCI文献检索 > JOURNAL OF VIRAL HEPATITIS期刊下所有文献 > HCV burden of infection in Egypt: results from a nationwide survey.

HCV burden of infection in Egypt: results from a nationwide survey.

Abstract：

:Egypt is the country with the largest hepatitis C virus (HCV) epidemic in the world. In 2008, a Demographic Health Survey (DHS) was carried out in Egypt, providing for the first time a unique opportunity for HCV antibody testing on a nationwide representative sample of individuals. Consenting individuals answered a questionnaire on socio-demographic characteristics and iatrogenic exposures, before providing a blood sample for HCV antibody testing by enzyme-linked immunosorbent assay. Factors independently associated with HCV infection were examined through multivariate logistic regression models. Of 12 780 eligible subjects aged 15-59 years, 11 126 (87.1%) agreed to participate and provided a blood sample. HCV antibody prevalence nationwide was 14.7% (95% CI 13.9-15.5%) in this age group. HCV antibody prevalence gradually increased with age, reaching, in the 50-59 years age group, 46.3% and 30.8% in males and females, respectively. It was higher in males compared to females (17.4% versus 12.2%, respectively, P < 0.001), and in rural compared to urban areas (18.3% versus 10.3%, respectively, P < 0.001). In multivariate analysis, age, male sex, poverty, past history of intravenous anti-schistosomiasis treatment, blood transfusion, and living outside of the Frontier Governorates were all significantly associated with an increased risk of HCV infection. In addition, in urban areas, lack of education and being circumcised for females were associated with an increased risk of HCV infection. This study confirmed on a nationwide representative sample the very high HCV antibody prevalence in Egypt. It stresses the urgent need for strengthening prevention efforts, and bringing down the costs of antiviral drugs for countries like Egypt, where the people in the most precarious situations are also those most likely to be infected by the virus.

journal_name

J Viral Hepat

journal_title

Journal of viral hepatitis

authors

Guerra J,Garenne M,Mohamed MK,Fontanet A

doi

10.1111/j.1365-2893.2011.01576.x

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

560-7

issue

8

eissn

1352-0504

issn

1365-2893

journal_volume

19

pub_type

杂志文章

相关文献

JOURNAL OF VIRAL HEPATITIS文献大全
  • Longitudinal genotype analysis and quantification of hepatitis C virus in haemophilic patients receiving interferon-alpha therapy.

    abstract：:Haemophilic patients have a high prevalence of hepatitis C virus (HCV) infection because of the use of unsterilized clotting factor concentrates. Six major genotypes of HCV have been distinguished so far, with epidemiological evidence suggesting that genotypes 1-3 are common in the indigenous UK and US populations. Th...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.1996.tb00080.x

    authors： Devereux H,Telfer P,Brown D,Morris A,Dusheiko G,Emery V,Lee C

    更新日期：1996-01-01 00:00:00

  • Long-term interferon-alpha treatment of children with chronic hepatitis delta: a multicentre study.

    abstract：:We assessed the efficacy of prolonged interferon-alpha (IFN) therapy in children with chronic hepatitis caused by hepatitis delta virus (HDV) by treating 26 paediatric cases with IFN-alpha 2b (5 MU m-2, then 3 MU m-2 three times weekly for 12 (medium-term group MTG) or 24 months (long-term group, LTG). Compliance and ...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/j.1365-2893.1996.tb00002.x

    authors： Di Marco V,Giacchino R,Timitilli A,Bortolotti F,Crivellaro C,Calzia R,Iannuzzi C,Prestileo T,Vajro P,Nebbia G,Stringhi C,Rosina F,Biassoni D,Callea F,Rizzetto M,Craxi A

    更新日期：1996-05-01 00:00:00

  • Tracing hepatitis C and Delta viruses to estimate their contribution in HCC rates in Mongolia.

    abstract：:An estimated incidence of hepatocellular carcinoma (HCC) in Mongolia is currently one of the highest in the world. According to previous reports, the sero-prevalence of hepatitis B (HBV) and hepatitis C (HCV) viruses in general population of the country is very high (HBV, 10% and HCV, 15%, respectively). Moreover, the...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2007.00864.x

    authors： Kurbanov F,Tanaka Y,Elkady A,Oyunsuren T,Mizokami M

    更新日期：2007-09-01 00:00:00

  • Altered balance between collagen formation and degradation after successful direct-acting antiviral therapy of chronic hepatitis C.

    abstract：:The effect of direct-acting antiviral (DAA) therapy on extracellular matrix (ECM) turnover, a prominent feature of chronic hepatitis C (CHC), is unknown. ECM protein degradation and formation generate fragments reflecting the tissue turnover balance when quantified in the blood. PRO-C3 and PRO-C4 reflect type III and ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13416

    authors： Laursen TL,Villesen IF,Leeming DJ,Karsdal MA,Sølund C,Tarp B,Kristensen LH,Holmboe CH,Leutscher P,Laursen AL,Gudmann NS,Grønbaek H

    更新日期：2021-02-01 00:00:00

  • Efficacy of interferon plus ribavirin in the treatment of hepatitis C virus genotype 5.

    abstract：:Hepatitis C virus (HCV) genotype 5 has only been reported in a few countries and treatment response has not been well characterized. Our aim is to present the treatment outcome for HCV genotype 5 patients evaluated at three medical centres in Syria between January 2004 and June 2007. Medical records were reviewed retr...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/j.1365-2893.2007.00946.x

    authors： Antaki N,Hermes A,Hadad M,Ftayeh M,Antaki F,Abdo N,Kebbewar K

    更新日期：2008-05-01 00:00:00

  • Natural history of serum HBV-RNA in chronic HBV infection.

    abstract：:Virus-like particles encapsulating HBV-RNA represent a serum biomarker for assessing viral replication activity in clinical practice. However, baseline levels of serum HBV-RNA and their associations with viral replicative intermediates and liver disease in phases of chronic hepatitis B remain unknown. In this cross-se...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12908

    authors： Wang J,Yu Y,Li G,Shen C,Li J,Chen S,Zhang X,Zhu M,Zheng J,Song Z,Wu J,Shao L,Meng Z,Wang X,Huang Y,Zhang J,Qiu C,Zhang W

    更新日期：2018-09-01 00:00:00

  • High levels of circulating N-terminal pro-brain natriuretic peptide in patients with hepatitis C.

    abstract：:Many patients chronically infected by hepatitis C virus (HCV) experience symptoms like fatigue, dyspnea and reduced physical activity. However, in many patients, these symptoms are not proportional to the liver involvement and could resemble symptoms of chronic heart failure. To our knowledge, no study evaluated serum...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2009.01237.x

    authors： Antonelli A,Ferri C,Ferrari SM,Colaci M,Sebastiani M,Zignego AL,Ghiri E,Goglia F,Fallahi P

    更新日期：2010-12-01 00:00:00

  • Dynamics of liver stiffness by transient elastography in patients with chronic hepatitis C virus infection receiving direct-acting antiviral therapy-Results from the German Hepatitis C-Registry.

    abstract：:The impact of direct-acting antiviral (DAA) therapies on fibrosis regression remains uncertain. In the current study, we prospectively evaluated dynamics of liver stiffness by transient elastography (TE) in patients with chronic HCV infection receiving DAA-based treatment. Patients (260) were enrolled in the German He...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13280

    authors： Knop V,Mauss S,Goeser T,Geier A,Zimmermann T,Herzer K,Postel N,Friedrich-Rust M,Hofmann WP,German Hepatitis C-Registry.

    更新日期：2020-07-01 00:00:00

  • Immunogenetics of hepatitis C virus.

    abstract：:Hepatitis C is a complex disease and a significant public health problem. The long-term outcome of HCV infection is difficult to predict, as the virus may be eliminated or may persist to establish a chronic infection. Further investigation is required to clarify factors that determine or influence the outcome of infec...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2893.2000.00022.x

    authors： McKiernan S,Kelleher D

    更新日期：2000-05-01 00:00:00

  • Different responses of rat liver adenosine metabolizing enzymes during in vivo and in vitro treatment with interferon-alpha 2b.

    abstract：:Interferon-alpha 2b (IFN-alpha 2b) can exert antiproliferative activity in both normal and malignant liver tissue. To study mechanisms of its antiproliferative action, the activity of the enzymes of adenosine metabolism were investigated. We studied 5'-nucleotidase (an adenosine-producing enzyme) and adenosine deamina...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.1998.00117.x

    authors： Kocić G,Kocić R,Vlahović P,Pavlović D,Jevtović T

    更新日期：1998-09-01 00:00:00

  • Single-nucleotide substitution of Hepatitis B virus in intrauterine infection.

    abstract：:The relationship between hepatitis B virus (HBV) gene polymorphism and intrauterine infection has not been completely illuminated. Six pairs of mother and infant from intrauterine infection group and six mothers from nonintrauterine infection group in the previous study were randomly selected and separately divided in...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12315

    authors： Wang LJ,Xu YF,Liu XX,Chen Y

    更新日期：2015-04-01 00:00:00

  • Quantitative evaluation of cytomegalovirus DNA in infantile hepatitis.

    abstract：:We used a PCR method to develop a diagnostic assay for the detection of cytomegalovirus (CMV) DNA in infantile hepatitis, which has been suggested to be associated with CMV infection. CMV DNA was detected in 25 (58.1%) of 43 patients with elevated serum alanine aminotransferase (ALT) levels but no jaundice, and no hep...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.2001.00277.x

    authors： Funato T,Satou N,Abukawa D,Satou J,Abe Y,Ishii KK,Iinuma K,Kaku M,Sasaski T

    更新日期：2001-05-01 00:00:00

  • Clinical utility of viral load measurements in individuals with chronic hepatitis C infection on antiviral therapy.

    abstract：SUMMARY:Both absolute viral load and log decline in viral load from baseline were found clinically useful in predicting sustained virological response and lack of sustained virological response (non-sustained virological response, NSVR) to treatment. We assessed the clinical utility of hepatitis C virus (HCV) RNA quant...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2005.00615.x

    authors： Terrault NA,Pawlotsky JM,McHutchison J,Anderson F,Krajden M,Gordon S,Zitron I,Perrillo R,Gish R,Holodniy M,Friesenhahn M

    更新日期：2005-09-01 00:00:00

  • Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.

    abstract：:Clinical and experimental studies have demonstrated that connective-tissue growth factor (CTGF) expression is increased in fibrotic human liver and experimental animal models of liver fibrogenesis. CTGF has been linked to transforming growth factor-beta (TGF-beta) pathways in fibroproliferative diseases and specific p...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2009.01110.x

    authors： Kovalenko E,Tacke F,Gressner OA,Zimmermann HW,Lahme B,Janetzko A,Wiederholt T,Berg T,Müller T,Trautwein C,Gressner AM,Weiskirchen R

    更新日期：2009-09-01 00:00:00

  • The expression of hepatitis B virus polymerase in hepatocytes during chronic HBV infection.

    abstract：:A recombinant protein corresponding to part of the amino-terminal domain of hepatitis B virus (HBV) polymerase was expressed in Escherichia coli. Antisera raised against this protein stained hepatocytes, from human liver biopsies, predominantly in the nucleus but some cytoplasmic staining was also observed. No stainin...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.1996.tb00083.x

    authors： McGarvey MJ,Goldin RD,Karayiannis P,Thomas HC

    更新日期：1996-03-01 00:00:00

  • Higher risk of hepatocellular carcinoma in chronic hepatitis B vs chronic hepatitis C after achievement of virologic response.

    abstract：:It is unclear whether the achievement of virologic response modifies the risk of hepatocellular carcinoma (HCC) differently in chronic hepatitis B (CHB) and chronic hepatitis C (CHC). Our aim was to compare the risk of HCC between patients with CHB and CHC who achieved virological response. We analysed data from patie...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12723

    authors： Kim GA,Han S,Kim HD,An J,Lim YS

    更新日期：2017-11-01 00:00:00

  • Serum miR-122 may serve as a biomarker for response to direct acting antivirals: effect of paritaprevir/R with dasabuvir or ombitasvir on miR-122 in HCV-infected subjects.

    abstract：:Circulating microRNAs (miRNA) have been intensely investigated as biomarkers in disease and therapy. Several studies have identified miR-122 as an important regulator of HCV replication. The effect of new therapies that directly target the HCV replication life cycle on circulating microRNA levels has not been elucidat...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,多中心研究

    doi：10.1111/jvh.12470

    authors： Waring JF,Dumas EO,Abel S,Coakley E,Cohen DE,Davis JW,Podsadecki T,Dutta S

    更新日期：2016-02-01 00:00:00

  • Hepatitis E virus infection among animals in northern India: an unlikely source of human disease.

    abstract：:Hepatitis E virus (HEV) is a major cause of acute hepatitis in many developing countries. Based on data from nonendemic regions, an animal reservoir of HEV has been proposed; however, data from HEV-endemic regions are limited. We tested sera from 200 pigs, 98 chickens, 86 goats, 58 sheep and 30 buffaloes for anti-HEV ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2006.00815.x

    authors： Shukla P,Chauhan UK,Naik S,Anderson D,Aggarwal R

    更新日期：2007-05-01 00:00:00

  • Evolution of glomerular filtration rate in HIV-infected, HIV-HBV-coinfected and HBV-infected patients receiving tenofovir disoproxil fumarate.

    abstract：:We aimed to compare the evolution of estimated glomerular filtration rate (eGFR) in HIV-, HIV-HBV- and HBV-infected patients treated with tenofovir disoproxil fumarate (TDF). Three groups of patients receiving TDF > 12 months were recruited: 194 HIV-infected patients, 85 HIV-HBV-coinfected patients and 50 HBV-infected...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12088

    authors： Pradat P,Le Pogam MA,Okon JB,Trolliet P,Miailhes P,Brochier C,Maynard M,Bailly F,Zoulim F,Cotte L

    更新日期：2013-09-01 00:00:00

  • DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that regulates gene expression of inflammatory mediators in liver injury. Hepatitis B virus (HBV) suppresses the PPAR gamma-mediated transactivation in liver cancerous cell lines. However, the role of PPAR gamma in patients with chroni...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12048

    authors： Zhao Q,Fan YC,Zhao J,Gao S,Zhao ZH,Wang K

    更新日期：2013-06-01 00:00:00

  • Clinical relevance of total HCV core antigen testing for hepatitis C monitoring and for predicting patients' response to therapy.

    abstract：:To study the correlation between total Hepatitis C virus (HCV) Core antigen (Ag) and HCV-RNA, and to assess the proficiency of HCV Core Ag testing in monitoring and predicting virologic response during and after pegylated interferon (PEG-IFN) and ribavirin combination therapy. A total of 307 samples from treated and u...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.2003.00430.x

    authors： Maynard M,Pradat P,Berthillon P,Picchio G,Voirin N,Martinot M,Marcellin P,Trepo C

    更新日期：2003-07-01 00:00:00

  • Serum PAI-1 is a novel predictor for response to pegylated interferon-α-2b plus ribavirin therapy in chronic hepatitis C virus infection.

    abstract：:Obesity and insulin resistance have been reported as negative predictors for sustained virological response (SVR) in hepatitis C virus (HCV) genotype 1 infected patients treated with pegylated interferon-α plus ribavirin. They are also known to affect serum levels of several cytokines including adipocytokines. But the...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01516.x

    authors： Miki D,Ohishi W,Ochi H,Hayes CN,Abe H,Tsuge M,Imamura M,Kamatani N,Nakamura Y,Chayama K

    更新日期：2012-02-01 00:00:00

  • Influence of the administration of human annexin V on in vitro binding of small hepatitis B surface antigen to human and to rat hepatocytes and on in vitro hepatitis B virus infection.

    abstract：:Previously, we have determined that human annexin V (hAV), a Ca2+-dependent phospholipid-binding protein, and not rat AV, binds specifically to small hepatitis B surface antigen (SHBsAg), and that transfection of a rat hepatoma cell line with a construct containing the hAV gene led to hAV expression and conferred susc...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.2000.00207.x

    authors： De Meyer S,Gong ZJ,Hertogs K,Depla E,van Pelt JF,Roskams T,Maertens G,Yap SH

    更新日期：2000-03-01 00:00:00

  • Cirrhosis, high age and high body mass index are risk factors for persisting advanced fibrosis after sustained virological response in chronic hepatitis C.

    abstract：:We aimed to assess fibrosis with liver stiffness measurement long-term after sustained virological response of chronic hepatitis C and to identify risk factors associated with persisting fibrosis. In this cross-sectional study, patients with chronic hepatitis C and pretreatment advanced fibrosis or cirrhosis treated s...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12879

    authors： Hedenstierna M,Nangarhari A,El-Sabini A,Weiland O,Aleman S

    更新日期：2018-07-01 00:00:00

  • Estimating the future health burden of chronic hepatitis C and human immunodeficiency virus infections in the United States.

    abstract：:The aim of this work was to estimate the future disease burden of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections in the United States until the year 2030. Two back-calculation models of the HIV and the HCV epidemic were developed. They were based on US epidemiological data regarding prevalen...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2006.00785.x

    authors： Deuffic-Burban S,Poynard T,Sulkowski MS,Wong JB

    更新日期：2007-02-01 00:00:00

  • A randomized trial to assess the efficacy of interferon-alpha daily in combination with ribavirin in the treatment of naïve patients with chronic hepatitis C.

    abstract：:A randomized trial was conducted to assess the efficacy of interferon-alpha (IFN) daily in combination with ribavirin in 301 naïve patients with chronic hepatitis C (CHC). Patients were randomized to receive ribavirin 1.2 g daily (QD) for 48 weeks with either IFN 5 MU (thrice weekly) TIW for 8 weeks followed by IFN 3 ...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2893.2003.00439.x

    authors： Tassopoulos NC,Ketikoglou I,Tsantoulas D,Raptopoulou M,Hatzis G,Vafiadis I,Sidiropoulos L,Kanatakis S,Anagnostopoulos G,Sypsa V,Hatzakis A,Hellenic Viral Hepatitis Research Network.

    更新日期：2003-09-01 00:00:00

  • Hepatitis delta virus propagation enabled by hepatitis C virus-Scientifically intriguing, but is it relevant to clinical practice?

    abstract：:In vitro cell culture experiments and animal models have demonstrated that hepatitis delta virus (HDV) can theoretically propagate being enveloped by human pathogenic viruses other than hepatitis B virus (HBV), namely hepatitis C virus (HCV) and dengue virus. However, the clinical relevance of these findings and wheth...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13385

    authors： Pflüger LS,Schulze Zur Wiesch J,Polywka S,Lütgehetmann M

    更新日期：2021-01-01 00:00:00

  • The ECHO model proved to be a useful tool to increase clinicians' self-effectiveness for care of patients with Hepatitis C in Argentina.

    abstract：:The ECHO model was developed to expand access to medical care for populations with HCV infection in underserved areas. We aimed to compare HCV treatment outcomes in community-based clinics with the Austral University Hospital (AUH) and to assess improvement in physician knowledge and skills. In October 2015, we establ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13172

    authors： Mendizabal M,Ridruejo E,Ceballos S,Sixto M,Billordo A,Gadea C,Mengarelli S,Alonso C,Palazzo A,De María L,Bruno A,Perez D,Piñero F,Deltrozzo V,Mendoza C,Figueroa S,Manero E,Villa M,Barreyro F,Moreno V,Vilar J,Mur

    更新日期：2019-11-01 00:00:00

  • Do antiviral CD8+ T cells select hepatitis C virus escape mutants? Analysis in diverse epitopes targeted by human intrahepatic CD8+ T lymphocytes.

    abstract：:Hepatitis C virus (HCV) is a variable RNA virus that can readily establish persistent infection. Cellular immune responses are important in the early control of the virus. Evidence from animal models suggests that mutation in epitopes recognized by CD8+ T lymphocytes may play an important role in the establishment of ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2005.00676.x

    authors： Komatsu H,Lauer G,Pybus OG,Ouchi K,Wong D,Ward S,Walker B,Klenerman P

    更新日期：2006-02-01 00:00:00

  • Peg-interferon and nucleos(t)ide analogue combination at inception of antiviral therapy improves both anti-HBV efficacy and long-term survival among HBV DNA-positive hepatocellular carcinoma patients after hepatectomy/ablation.

    abstract：:Antiviral therapy has been shown to improve the prognosis of hepatitis B virus (HBV) DNA-positive hepatocellular carcinoma (HCC) after radical treatment, but antiviral treatments require further optimization. This study aimed to evaluate the efficacies of different antiviral strategies with HCC patients after hepatect...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13236

    authors： Qi W,Zhang Q,Xu Y,Wang X,Yu F,Zhang Y,Zhao P,Guo H,Zhou C,Wang Z,Sun Y,Liu L,Xuan W,Wang J

    更新日期：2020-04-01 00:00:00