Different responses of rat liver adenosine metabolizing enzymes during in vivo and in vitro treatment with interferon-alpha 2b.

abstract：:We have recently shown that the replication of an HCV-poliovirus (PV) chimera that is dependent upon the hepatitis C virus (HCV) 5' untranslated region (UTR) can be inhibited by treatment with ribozymes targeting HCV RNA. To determine the antiviral effects of anti-HCV ribozyme treatment in combination with type 1 inte...

journal_title：Journal of viral hepatitis

authors： Macejak DG,Jensen KL,Pavco PA,Phipps KM,Heinz BA,Colacino JM,Blatt LM

更新日期：2001-11-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from chronic hepatitis C virus-infected persons can harbour viral variants that are not detected in plasma samples. We explored the presence and persistence of HCV genotypes in plasma and PBMC cultures from 25 HCV-monoinfected and 25 HIV/HCV-coinfected patients with haemophili...

journal_title：Journal of viral hepatitis

authors： Parodi C,García G,Monzani MC,Culasso A,Aloisi N,Corti M,Campos R,de E de Bracco MM,Baré P

更新日期：2015-07-01 00:00:00

abstract：:Endoglin, a transforming growth factor (TGF)-beta1 co-receptor, has been associated with renal and cutaneous fibrosis, as overexpression of this protein has been observed in biopsies from patients with glomerulosclerosis and scleroderma, respectively. Our aim was to evaluate whether endoglin may be associated with hep...

journal_title：Journal of viral hepatitis

authors： Clemente M,Núñez O,Lorente R,Rincón D,Matilla A,Salcedo M,Catalina MV,Ripoll C,Iacono OL,Bañares R,Clemente G,García-Monzón C

更新日期：2006-09-01 00:00:00

abstract：:In previous hepatitis C virus (HCV) treatment studies, Black patients not only had a lower sustained viral response (SVR) rate to interferon and ribavirin (RBV) than non-Black patients but also a higher frequency of HCV genotype 1 (GT-1) infection. The aim of this community-based study was to determine whether Black p...

journal_title：Journal of viral hepatitis

authors： Bräu N,Bini EJ,Currie S,Shen H,Schmidt WN,King PD,Ho SB,Cheung RC,Hu KQ,Anand BS,Simon FR,Aytaman A,Johnson DP,Awad JA,Ahmad J,Mendenhall CL,Pedrosa MC,Moseley RH,Hagedorn CH,Waters B,Chang KM,Morgan TR,Rossi

更新日期：2006-04-01 00:00:00

abstract：:Hepatitis A incidence has declined in most countries through a combination of prevention measures, augmented through the use of a highly effective vaccine. In Australia, the proportion of the population susceptible to hepatitis A infection has declined over time due to high rates of opportunistic vaccination as well a...

journal_title：Journal of viral hepatitis

authors： Jayasundara D,Hui BB,Regan DG,Heywood AE,MacIntyre CR,Wood JG

更新日期：2019-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is associated with insulin resistance (IR), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human ...

journal_title：Journal of viral hepatitis

authors： Jiménez-Sousa MA,Berenguer J,Fernández-Rodríguez A,Micheloud D,Guzmán-Fulgencio M,Miralles P,Pineda-Tenor D,García-Álvarez M,López JC,Aldámiz-Echevarria T,Carrero A,Resino S

更新日期：2014-03-01 00:00:00

abstract：:The aim of this study was to assess the efficacy and safety of two protocols for retreatment of a cohort of Egyptian patients with chronic hepatitis C (CHC) who relapsed after NS5A inhibitor-based therapy. We conducted a prospective cohort study to assess the safety and efficacy of 12 weeks' retreatment with either co...

journal_title：Journal of viral hepatitis

authors： Yousif MM,Ahmed H,Elsadek HM,Shendi AM,Gouda TM,Elsayed IA,Gendia MA,Magdy MM,Lbrahim NF,Sadek AMEM,Zaki AM,Shafeik H,Zahran MH

更新日期：2020-11-01 00:00:00

abstract：:Chronic hepatitis B (CHB) is characterized by an impaired immune response to hepatitis B virus. Among the nucleos(t)ides used in CHB treatment, telbivudine is associated with the highest rates of hepatitis B e antigen (HBeAg) seroconversion rates, which are similar to those observed with pegylated interferon (PegIFN)....

journal_title：Journal of viral hepatitis

authors： Wang GQ,Ding YP,Dong YH

更新日期：2013-04-01 00:00:00

abstract：:Anaemia during peginterferon (PEG-IFN) and ribavirin (RBV) therapy is common in human immunodeficiency virus/hepatitis C virus (HIV/HCV)-coinfected patients despite the use of lower doses of RBV than are recommended for HIV-seronegative persons. In addition, concurrent zidovudine (ZDV) may exacerbate the anaemia cause...

journal_title：Journal of viral hepatitis

authors： Alvarez D,Dieterich DT,Brau N,Moorehead L,Ball L,Sulkowski MS

更新日期：2006-10-01 00:00:00

abstract：:The aim of this work was to estimate the future disease burden of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections in the United States until the year 2030. Two back-calculation models of the HIV and the HCV epidemic were developed. They were based on US epidemiological data regarding prevalen...

journal_title：Journal of viral hepatitis

authors： Deuffic-Burban S,Poynard T,Sulkowski MS,Wong JB

更新日期：2007-02-01 00:00:00

abstract：:Summary.  Directly acting antiviral (DAA) agents are currently revolutionizing the treatment of chronic hepatitis C infection. The first generation of these agents have significant limitations including cost issues that are of particular concern in the developing world and a lack of efficacy in genotype 3 patients. Bo...

journal_title：Journal of viral hepatitis

authors： Ahmed F

更新日期：2013-05-01 00:00:00

abstract：:Approximately 30% of patients with chronic HCV infection have persistently normal ALT levels. Although formerly referred to as 'healthy' or 'asymptomatic' HCV carriers, and thus historically excluded from antiviral treatment, it has now become clear that the majority of these patients have some degree of histological ...

journal_title：Journal of viral hepatitis

authors： Puoti C,Guarisco R,Spilabotti L,Bellis L,Mitidieri Costanza O,Dell' Unto O,Elmo MG

更新日期：2012-04-01 00:00:00

abstract：:It is unclear whether the achievement of virologic response modifies the risk of hepatocellular carcinoma (HCC) differently in chronic hepatitis B (CHB) and chronic hepatitis C (CHC). Our aim was to compare the risk of HCC between patients with CHB and CHC who achieved virological response. We analysed data from patie...

journal_title：Journal of viral hepatitis

authors： Kim GA,Han S,Kim HD,An J,Lim YS

更新日期：2017-11-01 00:00:00

abstract：:The global scale-up of hepatitis C virus (HCV) diagnosis requires simplified and affordable HCV diagnostic pathways. This study evaluated the sensitivity and specificity of the HCV Architect core antigen (HCVcAg) assay for detection of active HCV infection in plasma and capillary whole blood dried blood spots (DBS) co...

journal_title：Journal of viral hepatitis

authors： Catlett B,Lamoury FMJ,Bajis S,Hajarizadeh B,Martinez D,Mowat Y,Cunningham PH,Jacka BP,Cloherty GA,Marks P,Dore GJ,Grebely J,Applegate TL

更新日期：2019-12-01 00:00:00

abstract：:Oral therapy for chronic hepatitis B remains suboptimal. Mathematical modelling of viral decay kinetics to rapidly assess potential antiviral regimens has proved valuable for human immunodeficiency virus and cytomegalovirus. We defined the kinetics of viral replication in 10 chronic hepatitis B patients randomized to ...

journal_title：Journal of viral hepatitis

authors： Wang CC,Holte S,Huang ML,Sacks SL,Engelberg R,Ferrenberg J,Shuhart M,Corey L

更新日期：2004-09-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the most common cause of endemic and epidemic acute hepatitis. A correlation between iNOS, eNOS polymorphisms, levels and severity of disease has been reported, and here, we examined the role of iNOS and eNOS gene polymorphisms and their levels in HEV-related acute viral hepatitis and acute ...

journal_title：Journal of viral hepatitis

authors： Hazam RK,Deka M,Kar P

更新日期：2014-01-01 00:00:00

abstract：:To test the concept that off-therapy hepatitis flares with increasing qHBsAg require immediate re-treatment whereas re-treatment can be held or not necessary for those with decreasing qHBsAg, pre-retreatment combined HBsAg/ALT kinetics were classified in 22 patients with severe hepatitis flare (ALT > 30X ULN) and chec...

journal_title：Journal of viral hepatitis

authors： Chien RN,Liaw YF

更新日期：2020-05-01 00:00:00

abstract：:Neumann et al. [1] developed a widely used model for the analysis of hepatitis C virus (HCV) dynamics after the initiation of interferon therapy that assumes the effectiveness of therapy in blocking virion production, epsilon, is constant. However, with pegylated interferon alpha-2b (PEG-IFN) given weekly, there are s...

journal_title：Journal of viral hepatitis

authors： Shudo E,Ribeiro RM,Perelson AS

更新日期：2008-05-01 00:00:00

abstract：:The study aimed to assess whether caesarean section and nonbreastfeeding can prevent mother-to-child transmission (MTCT) in HBsAg- and HBeAg-positive mothers via a cohort study and a meta-analysis. (1) Pregnant women who were positive for HBsAg and HBeAg and did not receive antiviral treatment during pregnancy were re...

journal_title：Journal of viral hepatitis

authors： Pan YC,Jia ZF,Wang YQ,Yang N,Liu JX,Zhai XJ,Song Y,Wang C,Li J,Jiang J

更新日期：2020-10-01 00:00:00

abstract：:This open label study was initiated to assess the safety and efficacy of lymphoblastoid interferon-alpha (IFN-alpha) and thymosin alpha 1 (T alpha 1) in the treatment of 11 patients with chronic hepatitis B, who had failed to respond to standard IFN-alpha 2b therapy, and in four interferon naive patients. These fiftee...

journal_title：Journal of viral hepatitis

authors： Rasi G,Mutchnick MG,Di Virgilio D,Sinibaldi-Vallebona P,Pierimarchi P,Colella F,Favalli C,Garaci E

更新日期：1996-07-01 00:00:00

abstract：:Hepatitis delta virus (HDV) RNA editing controls the formation of hepatitis-delta-antigen-S and -L and therefore indirectly regulates HDV replication. Editing is thought to be catalysed by the adenosine deaminase acting on RNA1 (ADAR1) of which two different forms exist, interferon (IFN)-alpha-inducible ADAR1-L and co...

journal_title：Journal of viral hepatitis

authors： Hartwig D,Schütte C,Warnecke J,Dorn I,Hennig H,Kirchner H,Schlenke P

更新日期：2006-03-01 00:00:00

abstract：:The role of ribavirin (RBV) in the era of direct-acting antivirals (DAA) is not clear, and DAA studies have been largely genotype- and regimen-specific. Using data from the Chronic Hepatitis Cohort Study, we evaluated the role of RBV and increased DAA treatment duration among patients with chronic hepatitis C (HCV) in...

journal_title：Journal of viral hepatitis

authors： Lu M,Wu KH,Li J,Moorman AC,Spradling PR,Teshale EH,Boscarino JA,Daida YG,Schmidt MA,Rupp LB,Zhang T,Trudeau S,Gordon SC

更新日期：2019-10-01 00:00:00

abstract：SUMMARY:A simian hepatitis A virus (HAV) was identified retrospectively in a faecal sample from a rhesus monkey in India, inoculated in 1995 with a faecal suspension from a suspected patient of non-A to E hepatitis. The monkey was in captivity for 2 years in one of the experimental primate facilities in western India b...

journal_title：Journal of viral hepatitis

authors： Arankalle VA,Ramakrishnan J

更新日期：2009-03-01 00:00:00

abstract：:The association between HBV infection and incident thrombocytopenia among subjects without cirrhosis or splenomegaly is unknown. Therefore, we sought to elucidate the association between HBV infection and the development of thrombocytopenia in a large cohort of apparently healthy men and women. A cohort study was perf...

journal_title：Journal of viral hepatitis

authors： Joo EJ,Chang Y,Yeom JS,Lee YG,Ryu S

更新日期：2017-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that regulates gene expression of inflammatory mediators in liver injury. Hepatitis B virus (HBV) suppresses the PPAR gamma-mediated transactivation in liver cancerous cell lines. However, the role of PPAR gamma in patients with chroni...

journal_title：Journal of viral hepatitis

authors： Zhao Q,Fan YC,Zhao J,Gao S,Zhao ZH,Wang K

更新日期：2013-06-01 00:00:00

abstract：:A randomized trial was conducted to assess the efficacy of interferon-alpha (IFN) daily in combination with ribavirin in 301 naïve patients with chronic hepatitis C (CHC). Patients were randomized to receive ribavirin 1.2 g daily (QD) for 48 weeks with either IFN 5 MU (thrice weekly) TIW for 8 weeks followed by IFN 3 ...

journal_title：Journal of viral hepatitis

authors： Tassopoulos NC,Ketikoglou I,Tsantoulas D,Raptopoulou M,Hatzis G,Vafiadis I,Sidiropoulos L,Kanatakis S,Anagnostopoulos G,Sypsa V,Hatzakis A,Hellenic Viral Hepatitis Research Network.

更新日期：2003-09-01 00:00:00

abstract：:Chronic infection with the hepatitis C virus is a major health problem. Conventional therapy, with interferon-alpha is effective in only a minority of patients. The failure of current treatments has led to a major initiative to identify new antiviral agents. In the absence of a tissue culture model for hepatitis C inf...

journal_title：Journal of viral hepatitis

authors： Clarke BE

更新日期：1995-01-01 00:00:00

abstract：:Morbidity and mortality attributable to chronic hepatitis C virus (HCV) infection are increasing in many countries as the infected population ages. Models were developed for 15 countries to quantify and characterize the viremic population, as well as estimate the number of new infections and HCV related deaths from 20...

journal_title：Journal of viral hepatitis

authors： Hatzakis A,Chulanov V,Gadano AC,Bergin C,Ben-Ari Z,Mossong J,Schréter I,Baatarkhuu O,Acharya S,Aho I,Anand AC,Andersson MI,Arendt V,Arkkila P,Barclay K,Bessone F,Blach S,Blokhina N,Brunton CR,Choudhuri G,Cisneros

更新日期：2015-01-01 00:00:00

abstract：:In hepatitis C virus (HCV) infection, serum viral load is important in the prediction of therapeutic efficacy. However, factors that affect the viral load remain poorly understood. To identify viral genomic elements responsible for the viral load, we investigated samples from a population of Irish women who were iatro...

journal_title：Journal of viral hepatitis

authors： Itakura J,Nagayama K,Enomoto N,Hamano K,Sakamoto N,Fanning LJ,Kenny-Walsh E,Shanahan F,Watanabe M

更新日期：2005-11-01 00:00:00

abstract：:The risk of perinatal transmission of hepatitis C virus (HCV) from a cohort of 95 human immunodeficiency virus (HIV)-negative intravenous drug users (IVDU) is described, 89 of whom were positive for antibodies to HCV (anti-HCV). Infection, defined as the presence of HCV RNA in a serum sample collected from an infant a...

journal_title：Journal of viral hepatitis

authors： Spencer JD,Latt N,Beeby PJ,Collins E,Saunders JB,McCaughan GW,Cossart YE

更新日期：1997-01-01 00:00:00