Abstract:
:The efficacy and tolerability of 12-month treatment with titrated doses of recombinant interferon-alpha 2a (IFN-alpha 2a) in chronic hepatitis C were studied in 67 consecutively recruited patients randomly assigned either to a starting dose of IFN-alpha 2a 6 MU, subsequently adjusted to the serum alanine aminotransferase (ALT) response (n = 35), or to no therapy (n = 32; controls). End-of-treatment ALT levels were normal and hepatitis C virus (HCV) RNA was negative by nested polymerase chain reaction (PCR) in 17 (49%) treated patients compared to none of the controls (P < 0.001). During the 12 months after stopping treatment the number of patients who remained in remission was eight (23%) and one respectively (4%) (P = 0.031). Follow-up liver biopsy showed reduced hepatic inflammation in 80% of treated patients and in 29% of controls (P < 0.001). The eight sustained responders and 27 non-responders or relapsers received similar mean total doses of IFN (565 MU vs 545 MU) and had a similar incidence of anti-IFN neutralizing antibodys (13% vs 19%). Absence of cirrhosis was the only independent pretreatment parameter that predicted a sustained response. In conclusion, a mean cumulative dose of IFN 549 MU, titrated over 12 months, was well tolerated, and resulted in the long-term clearance of HCV RNA and normal ALT levels in 23% of patients.
journal_name
J Viral Hepatjournal_title
Journal of viral hepatitisauthors
Rumi MG,del Ninno E,Parravicini ML,Romeo R,Soffredini R,Donato MF,Zahm F,Colombo Mdoi
10.1111/j.1365-2893.1995.tb00009.xsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
73-6issue
2eissn
1352-0504issn
1365-2893journal_volume
2pub_type
临床试验,杂志文章,随机对照试验abstract::Egypt is the country with the largest hepatitis C virus (HCV) epidemic in the world. In 2008, a Demographic Health Survey (DHS) was carried out in Egypt, providing for the first time a unique opportunity for HCV antibody testing on a nationwide representative sample of individuals. Consenting individuals answered a qu...
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/j.1365-2893.1995.tb00021.x
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journal_title:Journal of viral hepatitis
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