当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ORAL SCIENCES期刊下所有文献 > Effects on salivary flow rate and composition of withdrawal of and re-exposure to the beta 1-selective antagonist metoprolol in a hypertensive patient population.

Effects on salivary flow rate and composition of withdrawal of and re-exposure to the beta 1-selective antagonist metoprolol in a hypertensive patient population.

Abstract：

:Secretion rates and composition of unstimulated and chewing-stimulated whole saliva and 3% citric acid stimulated parotid and submandibular-sublingual secretions were studied in 12 hypertensive patients during withdrawal of and re-exposure to antihypertensive pharmacotherapy. All the patients' blood pressures were well controlled by monotherapy with metoprolol, a beta 1-selective adrenoceptor antagonist. Blood pressure measurements and saliva sampling were performed at about 9:30 a.m., 2 h after intake of breakfast, on days 0 (medicated baseline), 7, 14, 28 (nonmedicated experimental values and nonmedicated baseline) and 35 (medicated experimental values). A significant increase in unstimulated whole saliva secretion rate was observed when metoprolol was withdrawn and a corresponding decrease when the drug was reintroduced. A positive correlation was found between diastolic blood pressure levels and chewing-stimulated whole saliva secretion rates. In unstimulated whole saliva and 3% citric acid stimulated submandibular-sublingual secretion, the output of total protein, amylase, potassium, calcium and phosphate was significantly increased during the withdrawal period and decreased when metoprolol was reintroduced. For chewing-stimulated whole saliva, the corresponding changes were restricted to output of total protein and amylase, while for citric acid stimulated parotid secretion, no changes in salivary composition were observed. Finally, in all secretions one or both of the ratios hexosamine/total protein and sialic acid/total protein were affected, indicating a possible effect of beta-adrenoceptor antagonists on salivary protein synthesis.

journal_name

Eur J Oral Sci

journal_title

European journal of oral sciences

authors

Nederfors T,Dahlöf C

doi

10.1111/j.1600-0722.1996.tb00076.x

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

262-8

issue

3

eissn

0909-8836

issn

1600-0722

journal_volume

104

pub_type

杂志文章

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