Abstract：
:Diagnostic delay in oropharyngeal cancer may be associated with poor prognosis. As controversy exists on this topic because of contradictory results, the aim of this study was to perform a systematic review of the relationship between total diagnostic delay and advanced disease stages. A systematic search of MEDLINE, EMBASE, and ISI proceedings was made to identify observational studies that provided relative risks (RRs) and 95% confidence intervals (CIs) for patients with confirmed pathological diagnosis. The outcome of interest was disease stage (TNM classification), while the exposure of interest was the total diagnostic delay. The study-specific adjusted log RRs for cohort studies were weighted by the inverse of their variance to compute a pooled RR and its 95% CI. The fixed-effects pooled RR of advanced stages of oropharyngeal cancer when diagnostic delay is present was 1.32 (95% CI: 1.07-1.62). This association was stronger when the analysis was restricted to oral cancer (pooled RR: 1.47; 95% CI: 1.09-1.99) and when delay was longer than 1 month (pooled RR: 1.69; 95% CI: 1.26-2.77). The probability for patients with delayed diagnosis to present an advanced-stage tumour at diagnosis was significantly higher than that of patients with no delay in diagnosis. However, new prospective studies with strict methodology are needed to shed more light on this association.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Gómez I,Seoane J,Varela-Centelles P,Diz P,Takkouche Bdoi
10.1111/j.1600-0722.2009.00672.xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
541-6issue
5eissn
0909-8836issn
1600-0722pii
EOS672journal_volume
117pub_type
杂志文章,meta分析,评审abstract：:Patients with cardiac implantable electrical devices should take precautions when exposed to electromagnetic fields. Possible interference as a result of proximity to electromagnets or electricity flow from electronic tools employed in clinical odontology remains controversial. The objective of this study was to exami...
journal_title：European journal of oral sciences
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abstract：:In vitro investigations of cell-specific metabolism and cell interactions as well as biocompatibility studies are often hampered by the limited lifespan of primary cells originating from target tissues like the oral mucosa, gingiva or pulp. Pulp cells, as do other primary cells, undergo senescence after several passag...
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abstract：:Plasma arc light units for curing resin composites have been introduced with the claim of relatively short curing times. The purpose of the present study was to measure and compare elution of monomers from an experimental BisGMA-TEGDMA resin and a commercial resin composite when cured with a halogen unit and when cure...
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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doi：10.1111/j.1600-0722.1996.tb00076.x
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abstract：:This study evaluated the effect of core-design modification on the characteristic strength and failure modes of glass-infiltrated alumina (In-Ceram) (ICA) compared with porcelain fused to metal (PFM). Premolar crowns of a standard design (PFMs and ICAs) or with a modified framework design (PFMm and ICAm) were fabricat...
journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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abstract：:This study evaluated the effect of topical fluoride application on enamel hardness after in-office bleaching. Twelve human incisors were cut along the long axis, resulting in 24 halves used in four treatment groups (n = 6 in each group): (i) untreated group (C); (ii) in-office bleaching material (B); (iii) treatment w...
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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abstract：:Polydopamine-templated hydroxyapatite (tHA) is a type of nano-biomaterial that can promote osteogenesis in bone tissue engineering. However, high concentrations of tHA stimulate production of reactive oxygen species (ROS), resulting in cell injury and apoptosis. Metformin has been demonstrated to activate the adenosin...
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