Abstract：
:Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. The aim of this study was to investigate if VDR gene polymorphisms are associated with chronic periodontitis (CP) and aggressive periodontitis (AgP) in a Jordanian population. A total of 99 patients with CP, 63 patients with AgP, and 126 controls were genotyped using PCR-restriction fragment length polymorphism (RFLP) for BsmI, ApaI, and TaqI single nucleotide polymorphisms (SNPs). The association was determined after correcting for confounding factors using multivariate logistic regression analysis. Estimation of haplotype frequencies was carried out using the EH program, and haplotypes were constructed using the phase 2.1 program. After correcting for confounding factors, multivariate logistic regression analysis revealed that inheritance of the BsmI bb genotype or the ApaI aa genotype was associated with increased risk of developing CP (OR = 2.4 and OR = 3.4, respectively) but with reduced risk of developing AgP (OR = 0.4 and OR = 0.3, respectively). This was further supported by association of the ba haplotype with CP but not with AgP. This study supports an association of VDR gene polymorphisms with CP and AgP in a Jordanian population; however, the pattern of association was different between the two diseases.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Karasneh JA,Ababneh KT,Taha AH,Al-Abbadi MS,Marzouka Na,Jaradat SM,Thornhill MHdoi
10.1111/eos.12085subject
Has Abstractpub_date
2013-12-01 00:00:00pages
551-8issue
6eissn
0909-8836issn
1600-0722journal_volume
121pub_type
杂志文章abstract：:Polydopamine-templated hydroxyapatite (tHA) is a type of nano-biomaterial that can promote osteogenesis in bone tissue engineering. However, high concentrations of tHA stimulate production of reactive oxygen species (ROS), resulting in cell injury and apoptosis. Metformin has been demonstrated to activate the adenosin...
journal_title：European journal of oral sciences
pub_type： 杂志文章
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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doi：10.1034/j.1600-0722.2002.21317.x
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journal_title：European journal of oral sciences
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pub_type： 杂志文章
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更新日期：2005-08-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.1998.tb02200.x
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2006.00244.x
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12102
更新日期：2014-02-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 历史文章,杂志文章
doi：10.1111/eos.12586
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journal_title：European journal of oral sciences
pub_type： 杂志文章
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journal_title：European journal of oral sciences
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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abstract：:To investigate the arrangement of biofilms formed in vivo, volunteers wore splints with slabs of six different dental materials inserted to collect smooth surface plaque. After 5 d of undisturbed plaque accumulation, the specimens were vital stained and analyzed by the confocal laser scanning microscopy (CLSM) to eval...
journal_title：European journal of oral sciences
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更新日期：2002-02-01 00:00:00
abstract：:A considerable number of prescriptions for antibiotics are issued by dentists. Educational institutions have a special responsibility to promote informed attitudes among dental students towards prescribing antibiotics. The purpose of this study was to analyze the antibiotic prescriptions issued during a 5-year period ...
journal_title：European journal of oral sciences
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abstract：:Tooth development is regulated through a series of reciprocal interactions between the dental epithelium and mesenchyme and requires protein products of a number of genes. It has been reported that selective tooth agenesis is associated with mutations in human MSX and PAX9 genes. Mutational analysis of the two genes w...
journal_title：European journal of oral sciences
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