Abstract：
:Parathyroid hormone-related peptide (PTHrP) was discovered as the tumor product that is responsible for most instances of the syndrome of humoral hypercalcemia of malignancy. It is now known that the PTHrP and PTH genes arose on the basis of an ancient duplication event. One result of this heritage is a short stretch of highly homologous sequence at the N-terminus of each of the peptides, and another is the fact that these N-terminal products seem to be serviced by a single G protein-coupled receptor referred to as the type I receptor. Overexpression and null strategies in mice have recently provided convincing evidence that one such PTHrP function is as a developmental regulatory molecule. For example, overexpression of PTHrP in keratinocytes, mammary epithelial cells and chondrocytes results in a developmental phenotype in each case, while knockout of the gene is associated with a chondrodystrophy that is lethal at birth. Rescue of the PTHrP-null mouse via a genetic strategy involving a cross between the knockout mouse and a transgenic mouse with targeted PTHrP overexpression in chondrocytes provides a window on previously unappreciated PTHrP developmental regulatory effects in multiple tissues that share a common epithelial-mesenchymal morphogenetic background.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Philbrick WMdoi
10.1111/j.1600-0722.1998.tb02150.xsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
32-7eissn
0909-8836issn
1600-0722journal_volume
106 Suppl 1pub_type
杂志文章,评审abstract：:As a result of their presence throughout the mouth in the submucosa or between muscle fibers, minor salivary glands secrete directly and continuously into the oral cavity, providing mucosal surfaces with highly glycosylated proteins that are active in bacterial aggregation and in oral tissue lubrication. In this study...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2009.00700.x
更新日期：2010-02-01 00:00:00
abstract：:To explore the intrafamilial homology and longitudinal stability of colonization by early acquired mutans streptococci, genomic fingerprinting was performed on 254 strains (192 Streptococcus mutans and 62 Streptococcus sobrinus strains) collected from 16 families (16 mother-child pairs, seven fathers and four siblings...
journal_title：European journal of oral sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-0722.2003.00068.x
更新日期：2003-10-01 00:00:00
abstract：:The present study evaluated the failure risks of an endodontically treated premolar with severely damaged coronal hard tissue and restored with either a computer-aided design/computer-aided manufacturing (CAD/CAM) ceramic endocrown or a classical crown configuration. Two, three-dimensional finite element maxillary pre...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2009.00704.x
更新日期：2010-02-01 00:00:00
abstract：:The aim of this investigation was to study the intraoral pH response on tooth surfaces in relation to dental erosion during and after drinking a sugar-free cola-type soft drink. Six different methods of drinking were tested in a randomized order: holding; short-sipping; long-sipping; gulping; nipping; and sucking. Two...
journal_title：European journal of oral sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-0722.2004.00172.x
更新日期：2004-12-01 00:00:00
abstract：:Periodontitis progresses due to increased levels of active metalloproteinases (MMPs) and the imbalance between MMPs and their tissue inhibitors (TIMPs). Natural curcumin limits the lytic activity of MMPs but has low cellular uptake. Use of synthetic curcumin analogs could be a means of overcoming this limitation of tr...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12625
更新日期：2019-08-01 00:00:00
abstract：:At the mouse incisor tip the initially differentiated ameloblasts produce a thin, prism-free enamel, while further apically, in the immediate adjacent segment, the enamel thickness increases and the four-layered enamel of mouse incisor is formed. Comparative gene-expression profiling was carried out on RNA isolated fr...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2010.00722.x
更新日期：2010-04-01 00:00:00
abstract：:It has been suggested that occlusal interferences may lead to pain and tenderness of the masticatory muscles. Tender jaw muscles are more sensitive to pressure pain, as assessed by means of pressure algometry. We tested the effects of occlusal interferences on the pressure pain threshold of the jaw muscles by means of...
journal_title：European journal of oral sciences
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-0722.2006.00298.x
更新日期：2006-04-01 00:00:00
abstract：:Fast eating has been shown to increase the risk of overweight in both children and adults. The objectives of the present study were to investigate the correlation between chewing rate and the number of chews per mouthful and to evaluate if they were associated with the weight of meal intake. Thirty healthy subjects, a...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12583
更新日期：2019-02-01 00:00:00
abstract：:This study evaluated the effect of two desensitizers on inhibition of dentin demineralization, after immersion in artificial saliva using micro-computed tomography (μCT). Dentin blocks cut from bovine incisors were treated with deionized water (DW, a negative control) or one of three desensitizers: a fluoride varnish ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12155
更新日期：2014-12-01 00:00:00
abstract：:Granulocyte elastase was determined in the gingival crevicular fluid (GCF) of 18 periodontitis patients. They initially had similar severity of disease but had responded differently to 5-yr maintenance, 13 responders and 5 non-responders. A total of 102 sites were investigated and categorized as: i) consistently healt...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.1995.tb00121.x
更新日期：1995-04-01 00:00:00
abstract：:Proteolytic enzymes with gelatinolytic activity in the synovial fluid (SF) of temporomandibular joint (TMJ) arthropathies were assayed by gelatin-impregnated gel enzymography. SF samples were collected from 10 TMJs in patients with closed lock (CL) condition and 5 TMJs from asymptomatic healthy volunteers. Two protein...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1046/j.0909-8836.1998.eos106603.x
更新日期：1998-12-01 00:00:00
abstract：:The potential problems of DNA extraction from formalin-fixed paraffin-embedded (FFPE) tissue samples and amplification efficiency of Human papilloma virus (HPV) may occur in the molecular studies of head and neck squamous carcinoma (HNSCC). The aim of this study was to compare HPV detection rate in FFPE tissues of ora...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12746
更新日期：2020-12-01 00:00:00
abstract：:The aim of the present study was to examine pulp in amalgam-restored teeth of guinea pigs with respect to the presence of mercury, and to evaluate whether lining of cavities with resin modified glass ionomer cements had any effect on the penetration of mercury. Class V cavities were prepared in 63 incisor teeth of 21 ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1034/j.1600-0722.2002.21367.x
更新日期：2002-12-01 00:00:00
abstract：:The aim of this study was to characterize the sarcoplasmic-endoplasmic reticulum Ca-ATPase (SERCA) isoforms in rabbit masticatory muscles compared with those in fast-twitch muscle. It was hypothesized that combined expression of the SERCA isoforms in fast- and slow-twitch muscles accounts for lower Ca-ATPase activity....
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12098
更新日期：2014-02-01 00:00:00
abstract：:Aesthetic alternatives to stainless-steel crowns for restoring primary molars attain growing interest. We studied the mechanical properties of prefabricated zirconia crowns and conventional crowns. Three brands of prefabricated zirconia crowns were compared with computer-aided design/computer-aided manufacturing (CAD/...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12645
更新日期：2019-08-01 00:00:00
abstract：:The skeletal remains of Giovanna of Austria (1547-1578), daughter of the Emperor Ferdinand I of Habsburg (1503-1564) and first wife of the Grand Duke of Tuscany, Francesco I (1541-1587), exhumed from the Basilica of San Lorenzo in Florence, were submitted to paleopathological study. Examination of the dentition, which...
journal_title：European journal of oral sciences
pub_type： 传,历史文章,杂志文章
doi：10.1111/eos.12097
更新日期：2014-02-01 00:00:00
abstract：:Xylitol reduces plaque but the reduction mechanism is largely unknown. The main aim of the present study was to determine whether the xylitol-induced reduction in the amount of plaque and the number of mutans streptococci could be demonstrated in subjects with (presumably) high levels of xylitol-resistant (XR; not inh...
journal_title：European journal of oral sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-0722.1997.tb00196.x
更新日期：1997-04-01 00:00:00
abstract：:Relaxin (Rln) is an ovarian hormone that stimulates osteoclastic and osteoblastic activities and connective tissue turnover. To investigate the expression of Rln during orthodontic tooth movement, rats were implanted with orthodontic appliances that connected a spring from the upper incisors to the first molar with a ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2011.00814.x
更新日期：2011-04-01 00:00:00
abstract：:The aim of this study was to evaluate the postoperative consequences of chorda tympani reclining during middle ear surgery for otosclerosis. Electrogustometric taste thresholds were measured at 11 loci on the tongue and the soft palate in 14 patients before surgery, and 8 d, 1 month and (in some cases) 6 months after ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2008.00556.x
更新日期：2008-10-01 00:00:00
abstract：:The aim was to investigate risk indicators associated with dental erosive wear among 18-yr-old subjects in Oslo, Norway. Of 3,206 adolescents invited to participate in a screening examination for erosive wear, 1,456 were examined (giving a response rate of 45%). As part of the examination all participants completed a ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2012.00997.x
更新日期：2012-12-01 00:00:00
abstract：:The aim of this study was to test the influence of toothpaste and prophylaxis paste remnants as well as powder remnants on DIAGNOdent readings. A total of 68 sites on the occlusal surface of human molars were used for this study. After a cleaning procedure, saliva was spread on the tooth surface, dried for 3 s, and DI...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2004.00195.x
更新日期：2005-04-01 00:00:00
abstract：:Viridans streptococci possess a family of immunologically and structurally related cell-surface proteins, termed antigen I/II, which may function as adhesins and enable oral streptococci to adhere to saliva-coated surfaces and matrix proteins. Here we used atomic force microscopy in the molecular force mode to measure...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2010.00785.x
更新日期：2010-12-01 00:00:00
abstract：:The Wnt signalling pathway is involved in the development of oral cancer. When inactivated, secreted frizzled receptor protein 1 (SFRP1), a cellular Wnt-inhibitor protein, may enhance cancer development. The aim of this study was to assess the expression of SFRP1 in the invasive front of tongue squamous cell carcinoma...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12252
更新日期：2016-04-01 00:00:00
abstract：:The aim of this study was to determine the pattern of the antibacterial activity of chlorhexidine digluconate (CHX) against mature Streptococcus mutans biofilms. Streptococcus mutans biofilms were formed on saliva-coated hydroxyapatite discs and then treated with 0-20% CHX, once, three times, or five times (1 min per ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12285
更新日期：2016-10-01 00:00:00
abstract：:This study explored the relationships between sex, socio-economic status, social support, social network, dental clinical status, dental pain, oral health-related quality of life (OHRQoL), and self-rated oral health (SROH) in adolescents. A cross-sectional study involving 542 adolescents, aged 12-14 yr, was conducted ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12605
更新日期：2019-04-01 00:00:00
abstract：:The purpose of this study was to investigate the efficacy of an etchant in titanium bonding. The aqueous etchant consisted of 0, 5, or 10 wt% ammonium hydrogen fluoride (AHF) in combination with 0, 0.03, 0.3, or 3 wt% cupric chloride (CC). The two primers used were a phosphate-methacrylate primer and a thiophosphate-m...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.0909-8836.2004.00090.x
更新日期：2004-02-01 00:00:00
abstract：:The purpose of the present study was to investigate the effect of an experimental primer containing a microperoxidase (MP-11) with 2-hydroxyethyl methacrylate on adhesive bonding of three different luting systems and dentin. The luting systems prepared were three etch-and-rinse systems (10-3/Super-Bond, 10-0/Super-Bon...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2009.00634.x
更新日期：2009-06-01 00:00:00
abstract：:The formation of dental enamel is a prototype of functional tissue development through biomineralization. Amelotin (AMTN) is a recently discovered secreted enamel protein predominantly expressed during the maturation stage of enamel formation. It accumulates in a basal lamina-like structure at the interface between am...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2011.00870.x
更新日期：2011-12-01 00:00:00
abstract：:The aim of this in vitro study was to investigate the relationship between bacterial infections in carious dentin when detected by two different methods -- polymerase chain reaction (PCR), and a laser fluorescence device, DIAGNOdent. Dentin was removed every 300 micro m in the direction of the pulp chamber in 10 extra...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2004.00161.x
更新日期：2004-10-01 00:00:00
abstract：:The aims of this study were to evaluate the flexural strength of two different types of glass fibre-reinforced posts bonded to dual-cure composite resin cements. Forty glass methacrylate-based fibre posts (GC Fiber Post) and 20 glass fibre inter-polymerizing network posts (everStick POST) were divided into three group...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2010.00721.x
更新日期：2010-04-01 00:00:00
