Abstract：
:The renin-angiotensin system is thought to be involved in inflammatory processes such as periodontitis. However, its precise role is still unclear. Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin-1β (IL-1β)-induced interleukin-6 (IL-6) production by cultured human gingival fibroblasts (HGFs) was also studied. Immunohistochemical staining revealed that inflammatory cells and fibroblast-like cells were positive for the AT1R. However, in healthy gingival tissue, AT1R staining was very weak. The levels of AT1R mRNA and AT1R protein increased in HGFs after stimulation with IL-1β. The levels of IL-1β-induced IL6 mRNA and IL-6 protein were significantly reduced in AT1R gene-silenced HGFs compared with control HGFs. The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL-1β-induced IL-6 production in HGFs.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Nakamura T,Hasegawa-Nakamura K,Sakoda K,Matsuyama T,Noguchi Kdoi
10.1111/j.1600-0722.2011.00850.xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
345-51issue
5eissn
0909-8836issn
1600-0722journal_volume
119pub_type
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