Abstract：
:Immunosuppressive agents have been recognized as a factor affecting bone metabolism. The aim of the present study was to evaluate the influence of FK-506 administration on the healing of bone around titanium implants. Thirty-two male mice were randomly allocated to two groups: the FK-506 group (n = 16 mice), which received subcutaneous administration of FK-506 (1 mg kg-1 d-1 ); and the control group (n = 16 mice), which received saline solution by the same route of administration. After 2 wk, one titanium implant with sandblasted/acid-etched surface was placed in the femur. The therapy continued until the mice were killed 2 and 4 wk after surgery. The femurs with implants were evaluated by biomechanical testing and histologic analysis. The bone-implant contact (BIC) and bone volume (BV/TV) within a 100-μm-wide circumferential zone lateral to the implant surface were histomorphometrically analyzed. Compared with the control group, the FK-506 group showed significantly lower BIC and BV/TV at both 2 and 4 wk. Biomechanical tests showed that FK-506 significantly impaired the strength of bone-implant integration at both 2 and 4 wk postoperatively. Our data indicate that immunosuppressive therapy with FK-506 negatively affects the fixation of titanium implants.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Zheng X,Mo A,Wang Y,Guo Y,Wu Y,Yuan Qdoi
10.1111/eos.12320subject
Has Abstractpub_date
2017-02-01 00:00:00pages
28-33issue
1eissn
0909-8836issn
1600-0722journal_volume
125pub_type
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journal_title：European journal of oral sciences
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journal_title：European journal of oral sciences
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