Interaction of CodY, a novel Bacillus subtilis DNA-binding protein, with the dpp promoter region.

abstract：:In Escherichia coli, the SeqA protein is known as a negative regulator of chromosome replication. This protein is also suggested to have a role in chromosome organization. SeqA preferentially binds to hemi-methylated DNA and is by immunofluorescence microscopy seen as foci situated at the replication factories. Loss o...

journal_title：Molecular microbiology

authors： Klungsøyr HK,Skarstad K

更新日期：2004-10-01 00:00:00

abstract：:In the intracellular pathogen Brucella abortus, the general stress response (GSR) signalling system determines survival under acute stress conditions in vitro, and is required for long-term residence in a mammalian host. To date, the identity of the Brucella sensor kinase(s) that function to perceive stress and direct...

journal_title：Molecular microbiology

authors： Kim HS,Willett JW,Jain-Gupta N,Fiebig A,Crosson S

更新日期：2014-11-01 00:00:00

abstract：:Most of the structural components of the flagellum of Salmonella typhimurium are exported through a flagellum-specific pathway, which is a member of the family of type III secretory pathways. The export apparatus for this process is poorly understood. A previous study has shown that two proteins, about 23 and 26 kDa i...

journal_title：Molecular microbiology

authors： Fan F,Ohnishi K,Francis NR,Macnab RM

更新日期：1997-12-01 00:00:00

abstract：:Borrelia burgdorferi survives in an enzootic cycle, and Dps proteins protect DNA against damage during starvation or oxidative stress. The role of a Dps homologue encoded by Borrelia in spirochaete survival was assessed. Dps-deficient spirochaetes were infectious in mice via needle-inoculation at the dose of 10(5) spi...

journal_title：Molecular microbiology

authors： Li X,Pal U,Ramamoorthi N,Liu X,Desrosiers DC,Eggers CH,Anderson JF,Radolf JD,Fikrig E

更新日期：2007-02-01 00:00:00

abstract：:A novel growth phase-associated two-component-type regulator, Fas (fibronectin/fibrinogen binding/haemolytic activity/streptokinase regulator), of Streptococcus pyogenes was identified in the M1 genome sequence, based on homologies to the histidine protein kinase (HPK) and response regulator (RR) part of the Staphyloc...

journal_title：Molecular microbiology

authors： Kreikemeyer B,Boyle MD,Buttaro BA,Heinemann M,Podbielski A

更新日期：2001-01-01 00:00:00

abstract：:Bacterial biofilms contain subpopulations of cells that are dormant and highly tolerant to antibiotics. While dormant, the bacteria must maintain the integrity of macromolecules required for resuscitation. Previously, we showed that hibernation promoting factor (HPF) is essential for protecting Pseudomonas aeruginosa ...

journal_title：Molecular microbiology

authors： Akiyama T,Williamson KS,Franklin MJ

更新日期：2018-10-01 00:00:00

abstract：:The culturability of several actinobacteria is controlled by resuscitation-promoting factors (Rpfs). These are proteins containing a c. 70-residue domain that adopts a lysozyme-like fold. The invariant catalytic glutamate residue found in lysozyme and various bacterial lytic transglycosylases is also conserved in the ...

journal_title：Molecular microbiology

authors： Mukamolova GV,Murzin AG,Salina EG,Demina GR,Kell DB,Kaprelyants AS,Young M

更新日期：2006-01-01 00:00:00

abstract：:The efficiency of beta-lactam antibiotics, which are among our most useful chemotherapeutic weapons, is continuously challenged by the emergence of resistant bacterial strains. This is most often due to the production of beta-lactamases by the resistant cells. These enzymes inactivate the antibiotics by hydrolysing th...

journal_title：Molecular microbiology

authors： Frère JM

更新日期：1995-05-01 00:00:00

abstract：:A region of 7.8 kb of the plasmid pMB2 from Enterococcus faecalis S-48 carrying the information necessary for production and immunity of the peptide antibiotic AS-48 has been cloned and sequenced. It contains the as-48A structural gene plus five open reading frames (as-48B, as-48C, as-48C1, as-48D and as-48D1). Beside...

journal_title：Molecular microbiology

authors： Martínez-Bueno M,Valdivia E,Gálvez A,Coyette J,Maqueda M

更新日期：1998-01-01 00:00:00

abstract：:Bacterial chemoreceptors cluster into exquisitively sensitive, tunable, highly ordered, polar arrays. While these arrays serve as paradigms of cell signalling in general, it remains unclear what conformational changes transduce signals from the periplasmic tips, where attractants and repellents bind, to the cytoplasmi...

journal_title：Molecular microbiology

authors： Briegel A,Beeby M,Thanbichler M,Jensen GJ

更新日期：2011-11-01 00:00:00

abstract：:Neuroinvasive Escherichia coli K1 synthesizes and assembles a polysialic acid capsule virulence factor on the external leaflet of the outer membrane. This capsule functions in pathogenesis by blocking non-immune host defence mechanisms and acting as a relatively non-immunogenic molecular mimic of the polysialic acid c...

journal_title：Molecular microbiology

authors： Cieslewicz M,Vimr E

更新日期：1997-10-01 00:00:00

abstract：:The NarL and NarP proteins are homologous response regulators of Escherichia coli that control the expression of several operons in response to nitrate and nitrite. A consensus heptameric NarL DNA-binding sequence has been identified, and previous observations suggest that the NarP protein has a similar sequence speci...

journal_title：Molecular microbiology

authors： Darwin AJ,Tyson KL,Busby SJ,Stewart V

更新日期：1997-08-01 00:00:00

abstract：:Replication of the bacterial chromosome is initiated by the binding of the DnaA protein to a unique DNA region, called oriC. Many regulatory factors in numerous species act by controlling the ability of DnaA to bind and unwind DNA, but the Helicobacter pylori genome does not contain homologues to any of these factors....

journal_title：Molecular microbiology

authors： Zawilak-Pawlik A,Kois A,Stingl K,Boneca IG,Skrobuk P,Piotr J,Lurz R,Zakrzewska-Czerwińska J,Labigne A

更新日期：2007-08-01 00:00:00

abstract：:Cloning and sequencing of the IgA1 protease gene (iga) from Neisseria meningitidis strain HF13 showed an overall structure equivalent to iga genes from Neisseria gonorrhoeae and Haemophilus influenzae, although no region corresponding to the gonococcal alpha-peptide was evident. An additional 18 N. meningitidis and 3 ...

journal_title：Molecular microbiology

authors： Lomholt H,Poulsen K,Kilian M

更新日期：1995-02-01 00:00:00

abstract：:During pathogenesis, Mycobacterium tuberculosis (Mtb) colonizes environments, such as the macrophage or necrotic granuloma, that are acidic and rich in cholesterol and fatty acids. The goal of this study was to examine how acidic pH and available carbon sources interact to regulate Mtb physiology. Here we report that ...

journal_title：Molecular microbiology

authors： Baker JJ,Johnson BK,Abramovitch RB

更新日期：2014-10-01 00:00:00

abstract：:Although once thought to be unique to bacteria, d-amino acids are also produced by mammals. For example, d-serine is excreted in human urine at concentrations ranging from 3.0 to 40 micro g ml-1. An epidemiological survey demonstrated that urine isolates of E. coli are more likely to catabolise d-serine via expression...

journal_title：Molecular microbiology

authors： Roesch PL,Redford P,Batchelet S,Moritz RL,Pellett S,Haugen BJ,Blattner FR,Welch RA

更新日期：2003-07-01 00:00:00

abstract：:LeuO is a quiescent LysR-type regulator belonging to the H-NS regulon. Activation of leuO transcription represses expression of pathogenicity island 1 (SPI-1) in Salmonella enterica serovar Typhimurium and inhibits invasion of epithelial cells. Loss of HilE suppresses LeuO-mediated downregulation of SPI-1. Activation ...

journal_title：Molecular microbiology

authors： Espinosa E,Casadesús J

更新日期：2014-03-01 00:00:00

abstract：:The differences between archaeal and bacterial flagella are becoming more apparent as research on the archaeal structure progresses. One crucial difference is the presence of a leader peptide on archaeal preflagellins, which is removed from the flagellin prior to its incorporation into the flagellar filament. The enzy...

journal_title：Molecular microbiology

authors： Bardy SL,Jarrell KF

更新日期：2003-11-01 00:00:00

abstract：:Group II introns are mobile retroelements that invade their cognate intron-minus gene in a process known as retrohoming. They can also retrotranspose to ectopic sites at low frequency. Previous studies of the Lactococcus lactis intron Ll.LtrB indicated that in its native host, as in Escherichia coli, retrohoming occur...

journal_title：Molecular microbiology

authors： Coros CJ,Landthaler M,Piazza CL,Beauregard A,Esposito D,Perutka J,Lambowitz AM,Belfort M

更新日期：2005-04-01 00:00:00

abstract：:The stringent response is important for bacterial survival under stressful conditions, such as amino acid starvation, and is characterized by the accumulation of ppGpp and pppGpp. ObgE (CgtA, YhbZ) is an essential conserved GTPase in Escherichia coli and several observations have implicated the protein in the control ...

journal_title：Molecular microbiology

authors： Persky NS,Ferullo DJ,Cooper DL,Moore HR,Lovett ST

更新日期：2009-07-01 00:00:00

abstract：:We have built a homology model of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli based on the crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein. The resulting model of the hexameric ring of the ATP-bound form of the AAA ATPase suggests a plausible mechan...

journal_title：Molecular microbiology

authors： Karata K,Verma CS,Wilkinson AJ,Ogura T

更新日期：2001-02-01 00:00:00

abstract：:Stem-loop structures can protect upstream mRNA from degradation by impeding the processive activities of 3'-5' exoribonucleases. The ability of such structures to impede exonuclease activity in vitro is insufficient to account for the stability they can confer on mRNA in vivo. In this study we identify a factor from E...

journal_title：Molecular microbiology

authors： Causton H,Py B,McLaren RS,Higgins CF

更新日期：1994-11-01 00:00:00

abstract：:A recurring theme in morphogenesis is the coupling of the expression of genes that drive morphogenesis and the morphogenetic process per se. This coupling ensures that gene expression and morphogenesis are carried out in synchrony. Morphogenesis of the spore-filled fruiting bodies in Myxococcus xanthus illustrates thi...

journal_title：Molecular microbiology

authors： Søgaard-Andersen L,Overgaard M,Lobedanz S,Ellehauge E,Jelsbak L,Rasmussen AA

更新日期：2003-04-01 00:00:00

abstract：:The dominant, polA1-independent replicon of pGSH500, rep beta (1.8 kb), consists of a cis-acting oriV region of 245 bp; a repB gene that is essential for autonomous replication and 18, 30 to 36 bp iterons which constitute the inc/cop region. The molecular organization of rep beta resembles that of mini-pCU1 (IncN). Fu...

journal_title：Molecular microbiology

authors： da Silva-Tatley FM,Steyn LM

更新日期：1993-03-01 00:00:00

abstract：:Defensins represent an evolutionarily conserved group of small peptides with potent antibacterial activities. We report here that extracellular proteinases secreted by the human pathogens Pseudomonas aeruginosa, Enterococcus faecalis and Streptococcus pyogenes release dermatan sulphate by degrading dermatan sulphate-c...

journal_title：Molecular microbiology

authors： Schmidtchen A,Frick IM,Björck L

更新日期：2001-02-01 00:00:00

abstract：:The osteolytic toxin of Pasteurella multocida induces bone resorption in vivo and in vitro (Foged et al., 1988; Kimman et al., 1987). In this report the toxin-encoding toxA gene is sequenced, and the deduced primary structure of the toxin shows a protein of 1285 amino acids, containing a striking homology to a metal-b...

journal_title：Molecular microbiology

authors： Petersen SK

更新日期：1990-05-01 00:00:00

abstract：:PilO of Pseudomonas aeruginosa 1244 catalyses the attachment of an O-antigen repeating unit to the beta-carbon of the pilin C-terminal residue, a serine. The present study was conducted to locate the regions of this enzyme important in catalysis and to establish the cellular location of the pilin glycosylation reactio...

journal_title：Molecular microbiology

authors： Qutyan M,Paliotti M,Castric P

更新日期：2007-12-01 00:00:00

abstract：:The NAC (nitrogen assimilation control) protein from Klebsiella aerogenes is a LysR-like regulator for transcription of several operons involved in nitrogen metabolism, and couples the transcription of these sigma 70-dependent operons to regulation by the sigma 54-dependent NTR system. NAC activates expression of oper...

journal_title：Molecular microbiology

authors： Bender RA

更新日期：1991-11-01 00:00:00

abstract：:Microcins are a class of ribosomally synthesized antibacterial peptides produced by Enterobacteriaceae and active against closely related bacterial species. While some microcins are active as unmodified peptides, others are heavily modified by dedicated maturation enzymes. Low-molecular-weight microcins from the post-...

journal_title：Molecular microbiology

authors： Severinov K,Semenova E,Kazakov A,Kazakov T,Gelfand MS

更新日期：2007-09-01 00:00:00

abstract：:Multidrug resistant (MDR) strains of Acinetobacter baumannii present a serious clinical challenge. The development of antibiotic resistance in this species is enabled by efflux pumps of the Resistance-Nodulation-Division (RND) superfamily of proteins creating an efficient permeability barrier for antibiotics. At least...

journal_title：Molecular microbiology

authors： Leus IV,Adamiak J,Trinh AN,Smith RD,Smith L,Richardson S,Ernst RK,Zgurskaya HI

更新日期：2020-12-01 00:00:00