Abstract：
:Topical application and intraperitoneal administration of spiroarsoranes were carried out to cure central nervous system (CNS) trypanosomiasis in the chronic Trypanosoma brucei GVR 35 mouse model. Topical application appeared more efficient than intraperitoneal injection. The periods of aparasitaemia after treatment were longer but none of the mice was permanently cured. Combination treatment with eflornithine (DFMO) and the spiroarsoranes failed to show any synergistic effect. In addition, spiroarsorane I was evaluated against the T. b. rhodesiense KETRI 2634 strain, whereby 60-mg/kg treatment produced a noticeable prolongation of the life span of trypanosome-positive animals. These in vivo results suggests that the spiroarsoranes have difficulty in crossing the blood-brain barrier (BBB) and clearing the parasites from the CNS or, alternatively, that these strains are less sensitive to pentavalent arsenicals than the T. b. brucei CMP fast strain, which in the present study was more sensitive to spiroarsoranes whose lipophilicity corresponded to a log-P value ranging from 2.5 to 3.7.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Loiseau PM,Jennings FW,Lubert P,Wolf JGdoi
10.1007/s004360050148subject
Has Abstractpub_date
1996-01-01 00:00:00pages
477-80issue
5eissn
0932-0113issn
1432-1955journal_volume
82pub_type
杂志文章abstract：:Lungworms of the genera Parafilaroides and Otostrongylus are responsible for parasitic bronchopneumonia, the foremost disease of eastern Atlantic common seals (EACS, Phoca vitulina vitulina) in the Dutch North Sea. Recently, there have been increased reports of lungworm cases and observations of unusually long Parafil...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06675-7
更新日期：2020-06-01 00:00:00
abstract：:A high-resolution melting (HRM) assay was applied to distinguish between Giardia duodenalis assemblages A and B from human and dog feces based on the triosephosphate isomerase gene (tpi). The genomic DNAs were selected from assemblages A (WB) and B (GS) as reference and plasmids were constructed. The reference plasmid...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3064-x
更新日期：2012-11-01 00:00:00
abstract：:Mosquitoes (Diptera: Culicidae) are a key threat for millions of people worldwide, since they act as vectors for devastating pathogens and parasites. The standard method of utilisation of morphological characters becomes challenging due to various factors such as phenotypical variations. We explored the complementary ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4726-2
更新日期：2016-01-01 00:00:00
abstract：:Resveratrol, a natural phytoalexin found mainly in grapes, possesses a variety of beneficial activities including anticancer, antimicrobial and antiviral. However, there is no information about its effects on kinetoplastid parasites such as Leishmania. Leishmania is a human pathogen responsible for a spectrum of disea...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0729-y
更新日期：2007-12-01 00:00:00
abstract：:A parasitological survey of 651 northern fur seals Callorhinus ursinus L. from five subpopulations was conducted on St. Paul Island, Alaska, during July-August 2012-2014. Digenean trematodes were found in 210 of 651 fur seals with a total prevalence of 32.3%. Intensity of infection varied from 1 to 1540 parasites with...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5784-z
更新日期：2018-04-01 00:00:00
abstract：:Probolocoryphe species occur primarily as intestinal parasites of birds and mammals. Infection of the crab Nanosesarma minutum with the metacercarial cyst stages of Probolocoryphe uca is common in Kuwait Bay. In this study, the snail Cerithidea cingulata was used to determine if it would serve as first intermediate ho...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1778-1
更新日期：2010-04-01 00:00:00
abstract：:Rodents are intermediate hosts for many species of Sarcocystis. Little is known of Sarcocystis cymruensis that uses the Brown rat (Rattus norvegicus) as intermediate hosts and the domestic cat (Felis catus) as experimental definitive host. Here, we identified and described Sarcocystis cymruensis in naturally infected ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5799-5
更新日期：2018-04-01 00:00:00
abstract：:In 2001, an international surveillance initiative was established, utilising a validated larval development inhibition assay to track the susceptibility of cat flea isolates to imidacloprid. In 2009, an Australian node was incorporated into the programme, joining laboratories in the United States and Europe. Field iso...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3280-z
更新日期：2013-08-01 00:00:00
abstract：:In Egypt, reclaiming portions of the desert using water from the Nile has resulted in large-scale invasion of Biomphalaria alexandrina in these regions. Studies exploring the local adaptation of Schistosoma mansoni to its snail host have been carried out to predict the extension of schistosomiasis to newly reclaimed a...
journal_title：Parasitology research
pub_type： 杂志文章,meta分析
doi：10.1007/s00436-014-3756-5
更新日期：2014-03-01 00:00:00
abstract：:The relationships between inflammation in organs with Toxocara canis larval migration and matrix metalloproteinase-9 (MMP-9) were investigated following the infection of mice with 1,000 infective eggs. Gelatinase activity was defined by gelatin zymography, optimum pH, inhibitor specificity and Western blot analysis. M...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1271-9
更新日期：2005-02-01 00:00:00
abstract：:The use of the term guild community as an intermediate level between component and supra-community proves to be advantageous within the different steps of parasite communities. It can comprise more information than a component community but researchers are able to analyse important parts of the supra-community without...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s004360100386
更新日期：2001-06-01 00:00:00
abstract：:The acanthocephalan Acanthocephalus dirus is a trophically transmitted parasite that modifies both the physiology and behavior of its intermediate host (isopod) prior to transmission to its definitive host (fish). Infected isopods often contain multiple A. dirus individuals and we examined the relationships between ho...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5279-8
更新日期：2017-01-01 00:00:00
abstract：:As part of a biological inventory of the Rio Lacantún basin in the Biosphere Reserve of Montes Azules from Chiapas State (southeastern, Mexico), the following monogenoid ectoparasites infecting the external surface of the anal opening and the gill lamellae of the freshwater fish Astyanax aeneus (Characidae) in ten str...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3126-0
更新日期：2013-01-01 00:00:00
abstract：:We have previously reported the involvement of cyclic AMP in regulating flagellar waveforms in Leishmania. Here, we investigated the roles of calcium, calmodulin, and calcineurin in flagellar motility regulation in L. donovani. Using high-speed videomicroscopy, we show that calcium-independent calmodulin and calcineur...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5608-6
更新日期：2017-11-01 00:00:00
abstract：:Transferrin is a defence protein known to be up-regulated upon infection of parasites/pathogens in Aedes aegypti mosquito. However, no information is available on its up-regulation in Culex quinquefasciatus, the vector of bancroftian filarial parasite. In the present study, enhancement of transferrin in C. quinquefasc...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0474-2
更新日期：2007-07-01 00:00:00
abstract：:When in vitro cultivation was used as the 'gold standard' for the detection of Blastocystis hominis in stool specimens, simple smear and trichrome staining showed sensitivities of 16.7% and 40.2% and specificities of 94% and 80.4%, respectively. In vitro cultivation also enhanced PCR amplification for the detection of...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1157-x
更新日期：2004-08-01 00:00:00
abstract：:No fully effective treatment has been developed since the discovery of Chagas' disease. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effective in the acute phase but with various adverse side effects, more studies are needed to characterize the susceptibility of T. cruzi to n...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2275-x
更新日期：2011-08-01 00:00:00
abstract：:Mosquitoes are important vectors of diseases to humans and domestic animals. Chemical control of vectors remains a main resource for the prevention and control of vector-borne diseases. Due to the development of insecticide resistance and risks to human health and the environment of synthetic compounds, the search for...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0647-z
更新日期：2007-10-01 00:00:00
abstract：:The eggshells of young developmental stages in the uterus are rather thin and homogenous. In the brezel stage of Brugia malayi they are 35 nm thick and 20 nm in Litomosoides carinii. In young developmental stages up to brezel stages the eggshells bind the lectins WGA, DBA and PNA labelled with colloidal gold. This sho...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00535333
更新日期：1987-01-01 00:00:00
abstract：:Susceptibility or resistance to infection with Cryptosporidium parvum correlates with the ability of mice to produce characteristic panels of cytokines in response to infection. Both adult healing and nonhealing mouse models of cryptosporidiosis were used to study the cell-mediated immune response during the course of...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-1436-1
更新日期：2005-10-01 00:00:00
abstract：:An experiment was conducted to study the adjuvant effect of ginsomes on the recombinant profilin in coccidian-infected breeding birds. Three-day-old chickens were vaccinated with Eimeria tenella recombinant profilin antigen (10, 50, and 100 μg per chicken) with or without 50 μg ginsomes per chicken. The boost vaccinat...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2784-7
更新日期：2012-06-01 00:00:00
abstract：:The fine structure of the infective hexacanths of Echinococcus multilocularis was examined with particular emphasis on the functional ultrastructure of penetration glands and nerve cells directly involved in the mechanism of initial host infection. The oncosphere contains two types of penetration glands, PG1 and PG2, ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5957-9
更新日期：2018-08-01 00:00:00
abstract：:Macroscopically visible sarcocysts were observed in the skeletal muscles of naturally infected skinks of the genus Agama (infection rate 11.3%). Sarcocysts were described by means of transmission electron microscopy. These cysts measured 0.03-0.25 x 0.38-1.7 mm (mean 0.12 x 1.1 mm). Typical mature cysts were bordered ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/pl00008559
更新日期：2000-09-01 00:00:00
abstract：:We investigated the prevalence and genotypes of Cryptosporidium parasite in 50 brown rats (Rattus norvegicus) inhabiting an urban area of Japan. Fecal samples collected from the animals were examined by an immuno-fluorescence assay (IFA). Genomic DNA was extracted directly from fecal sample of each animal and nested P...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0488-9
更新日期：2007-05-01 00:00:00
abstract：:Cystic echinococcosis (CE) is a widespread zoonosis. For treating single echinococcal cysts during the last decades, therapeutic puncture of the cyst, aspiration, injection of a scolicide, and re-aspiration (PAIR) has been established as a minimal-invasive alternative method to surgery. A recent review on the complica...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-4275-0
更新日期：2015-02-01 00:00:00
abstract：:This experimental study on pigs was designed to simulate natural, long-term exposure to Ascaris suum under modern management conditions. Parasite kinetics were followed in pigs receiving A. suum eggs as repeated trickle inoculations at two dose levels beginning at a body weight of 25 kg until their slaughter at 90 kg ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931733
更新日期：1992-01-01 00:00:00
abstract：:The development of plant-derived cysteine proteinases, such as those in papaya latex, as novel anthelmintics requires that the variables affecting efficacy be fully evaluated. Here, we conducted two experiments, the first to test for any effect of host sex and the second to determine whether the intensity of the worm ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4456-5
更新日期：2015-07-01 00:00:00
abstract：:The insect growth regulator, Lufenuron, at concentrations of even multiples of LC(90) (determined under laboratory conditions) was tested against the III instar larvae of Aedes aegypti under simulated field conditions. For all concentrations tested, 100 % mortality of the larvae was observed within 24 h of exposure to...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-2968-9
更新日期：2012-09-01 00:00:00
abstract：:According to the genetic characterization by the analysis of the miniexon gene, strains of Trypanosoma cruzi can be classified into six discrete typing units (DTUs), and the DTU 1 into four distinct genotypes associated with different life cycles. While Chagas disease is endemic in Costa Rica, T. cruzi isolates from t...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3000-0
更新日期：2012-10-01 00:00:00
abstract：:Morphology of capsules surrounding acanthocephalan Corynosoma strumosum in paratenic hosts (sea fishes of three species from the northern part of the Sea of Okhotsk) was studied. A thick layer of glycocalyx is formed on the surface of acanthocephalan's tegument in smelts Osmerus mordax dentex and Hypomesus olidus; the...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2088-3
更新日期：2011-02-01 00:00:00
