Budding of equine infectious anemia virus is insensitive to proteasome inhibitors.

abstract：:All positive-strand RNA viruses reorganize host intracellular membranes to assemble their replication complexes. Similarly, brome mosaic virus (BMV) induces two alternate forms of membrane-bound RNA replication complexes: vesicular spherules and stacks of appressed double-membrane layers. The mechanisms by which these...

journal_title：Journal of virology

authors： Zhang J,Diaz A,Mao L,Ahlquist P,Wang X

更新日期：2012-05-01 00:00:00

abstract：:We have investigated the ability of human immunodeficiency virus type 1 (HIV-1) and HIV-2 isolates to infect and replicate in primary human macrophages. Monocytes from blood donors were allowed to differentiate into macrophages by culture in the presence of autologous lymphocytes and human serum for 5 days before infe...

journal_title：Journal of virology

authors： Valentin A,Albert J,Fenyö EM,Asjö B

更新日期：1994-10-01 00:00:00

abstract：:Human immunodeficiency virus clade C (HIV-C) accounts for >56% of all HIV infections worldwide. To investigate vaccine safety and efficacy in nonhuman primates, a pathogenic, R5-tropic, neutralization-sensitive simian-human immunodeficiency virus (SHIV) carrying HIV-C env would be desirable. We have constructed SHIV-2...

journal_title：Journal of virology

authors： Siddappa NB,Song R,Kramer VG,Chenine AL,Velu V,Ong H,Rasmussen RA,Grisson RD,Wood C,Zhang H,Kankasa C,Amara RR,Else JG,Novembre FJ,Montefiori DC,Ruprecht RM

更新日期：2009-02-01 00:00:00

abstract：:Infection of cells with herpes simplex virus type 1 (HSV-1) results in a rapid alteration of phosphorylation on the large subunit of cellular RNA polymerase II (RNAP II), most likely on its C-terminal domain (S. A. Rice, M. C. Long, V. Lam, C. A. Spencer, J. Virol. 68:988-1001, 1994). This phosphorylation modification...

journal_title：Journal of virology

authors： Rice SA,Long MC,Lam V,Schaffer PA,Spencer CA

更新日期：1995-09-01 00:00:00

abstract：:Changes in the envelope glycoprotein ectodomains of a nonpathogenic simian-human immunodeficiency virus (SHIV-89.6) that was serially passaged in vivo have been shown to be responsible for the increased pathogenicity of the resulting virus, SHIV-KB9 (G. B. Karlsson, et al., J. Exp. Med. 188:1159-1171, 1998). The 12 am...

journal_title：Journal of virology

authors： Etemad-Moghadam B,Sun Y,Nicholson EK,Fernandes M,Liou K,Gomila R,Lee J,Sodroski J

更新日期：2000-05-01 00:00:00

abstract：:Nef, an accessory protein of human and simian immunodeficiency viruses, is a critical determinant of pathogenesis that promotes the progression from infection to AIDS. The pathogenic effects of Nef are in large part dependent on its ability to downregulate the macrophage and T-cell coreceptor, CD4. It has been propose...

journal_title：Journal of virology

authors： Chaudhuri R,Lindwasser OW,Smith WJ,Hurley JH,Bonifacino JS

更新日期：2007-04-01 00:00:00

abstract：:Polyoma virus particles were purified by equilibrium centrifugation in CsCl. Particles from three regions of the density gradient were examined for infectivity, for their ability to induce expanded pools of deoxyribonucleic acid (DNA) precursors, and for their ability to stimulate the synthesis of DNA. The most infect...

journal_title：Journal of virology

authors： Skoog L,Nordenskjöld BA,Lindberg U

更新日期：1970-07-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) lytic DNA replication is initiated at the complex cis-acting oriLyt region, which spans nearly 3 kb. DNA synthesis requires six core proteins together with UL84 and IE2. Previously, two essential regions were identified within oriLyt. Essential region I (nucleotides [nt] 92209 to 92573) ca...

journal_title：Journal of virology

authors： Colletti KS,Smallenburg KE,Xu Y,Pari GS

更新日期：2007-07-01 00:00:00

abstract：UNLABELLED:Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster. Membrane fusion is essential for VZV entry and the distinctive syncytium formation in VZV-infected skin and neuronal tissue. Herpesvirus fusion is mediated by a complex of glycoproteins gB and gH-gL, which are necess...

journal_title：Journal of virology

authors： Yang E,Arvin AM,Oliver SL

更新日期：2016-07-27 00:00:00

abstract：:Mengovirus 14S subviral protein particles generated in infected L cells and in a cell-free translation system primed with mengovirus RNA were purified by sucrose gradient centrifugation and immunoaffinity chromatography. The preparations from both sources contained essentially pure proteins epsilon, alpha, and gamma, ...

journal_title：Journal of virology

authors： Boege U,Ko DS,Scraba DG

更新日期：1986-01-01 00:00:00

abstract：:West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by double labeling for WNV antigen and keratin 10. Inoculation of mice ...

journal_title：Journal of virology

authors： Lim PY,Behr MJ,Chadwick CM,Shi PY,Bernard KA

更新日期：2011-05-01 00:00:00

abstract：:Studies of rotavirus morphogenesis, transport, and release have shown that although these viruses are released from the apical surface of polarized intestinal cells before cellular lysis, they do not follow the classic exocytic pathway. Furthermore, increasing evidence suggests that lipid rafts actively participate in...

journal_title：Journal of virology

authors： Cuadras MA,Bordier BB,Zambrano JL,Ludert JE,Greenberg HB

更新日期：2006-04-01 00:00:00

abstract：:The therapeutic efficacy of direct drug infusion into the brain, the target organ of transmissible spongiform encephalopathies, was assessed in transgenic mice intracerebrally infected with 263K scrapie agent. Pentosan polysulfate (PPS) gave the most dramatic prolongation of the incubation period, and amphotericin B h...

journal_title：Journal of virology

authors： Doh-ura K,Ishikawa K,Murakami-Kubo I,Sasaki K,Mohri S,Race R,Iwaki T

更新日期：2004-05-01 00:00:00

abstract：:We have selected neutralization escape mutants by using a monoclonal antibody (nt-MAb) against a sequential epitope between amino acids 93 through 104 (neutralization antigenic site I) of poliovirus type 1 Mahoney. The majority of mutants were also resistant against five strain-specific nt-MAbs which recognized confor...

journal_title：Journal of virology

authors： Wiegers K,Uhlig H,Dernick R

更新日期：1988-05-01 00:00:00

abstract：:Acute measles in children can be prevented by immunization with the live attenuated measles vaccine virus. Although immunization is able to induce CD4 and CD8 T cells as well as neutralizing antibodies, only the latter have been correlated with protective immunity. CD8 T cells, however, have been documented to be impo...

journal_title：Journal of virology

authors： Pueschel K,Tietz A,Carsillo M,Steward M,Niewiesk S

更新日期：2007-08-01 00:00:00

abstract：:We analyzed peripheral blood mononuclear cells from 19 asymptomatic seropositive pregnant women from the district of Gulu in northern Uganda. A 700-bp fragment of the human immunodeficiency virus type 1 (HIV-1) env gene, including the V3-V5 region, was successfully amplified by PCR from 10 samples (52.6%) and was subs...

journal_title：Journal of virology

authors： Buonaguro L,Del Guadio E,Monaco M,Greco D,Corti P,Beth-Giraldo E,Buonaguro FM,Giraldo G

更新日期：1995-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection remains a major worldwide health problem despite development of highly effective direct-acting antivirals. HCV rapidly evolves upon acute infection and generates multiple viral variants (quasispecies), leading to immune evasion and persistent viral infection. Identification of epitope...

journal_title：Journal of virology

authors： Tong Y,Li Q,Li R,Xu Y,Pan Y,Niu J,Zhong J

更新日期：2020-08-17 00:00:00

abstract：:The membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive neutralizing antibody 2F5. It has been proposed that 2F5 neutralization might involve interaction of its long, ...

journal_title：Journal of virology

authors： Ou W,Lu N,Yu SS,Silver J

更新日期：2006-03-01 00:00:00

abstract：:Measles virus (MeV) infection is characterized by the formation of multinuclear giant cells (MGC). We report that beta interferon (IFN-beta) production is amplified in vitro by the formation of virus-induced MGC derived from human epithelial cells or mature conventional dendritic cells. Both fusion and IFN-beta respon...

journal_title：Journal of virology

authors： Herschke F,Plumet S,Duhen T,Azocar O,Druelle J,Laine D,Wild TF,Rabourdin-Combe C,Gerlier D,Valentin H

更新日期：2007-12-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) vectors that express heterologous antigens have shown promise as vaccines in preclinical studies. The efficacy of VSV-based vaccines can be improved by engineering vectors that enhance innate immune responses. We previously generated a VSV vaccine vector that incorporates two enhancing...

journal_title：Journal of virology

authors： Smedberg JR,Westcott MM,Ahmed M,Lyles DS

更新日期：2014-01-01 00:00:00

abstract：:Flock house virus is a small insect virus with a bipartite RNA genome consisting of RNA1 and RNA2. RNA3 is a subgenomic element encoded by RNA1, the genomic segment required for viral RNA synthesis (T. M. Gallagher, P. D. Friesen, and R. R. Rueckert, J. Virol. 46:481-489, 1983). Synthesis of RNA3 is strongly inhibited...

journal_title：Journal of virology

authors： Zhong W,Rueckert RR

更新日期：1993-05-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a single-stranded DNA virus with a unique biphasic lifestyle consisting of both a productive and a latent phase. Typically, the productive phase requires coinfection with a helper virus, for instance adenovirus, while the latent phase dominates in healthy cells. In the latent state, AAV...

journal_title：Journal of virology

authors： Hamilton H,Gomos J,Berns KI,Falck-Pedersen E

更新日期：2004-08-01 00:00:00

abstract：:Despite the long-standing observation that herpes simplex virus (HSV) latency-associated transcript (LAT) promoter deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. We constructed and evaluated four mutant HSV...

journal_title：Journal of virology

authors： Kawamura Y,Bosch-Marce M,Tang S,Patel A,Krause PR

更新日期：2018-06-29 00:00:00

abstract：:Among the numerous immunological abnormalities observed in chronically human immunodeficiency virus (HIV)-infected individuals, perturbations in memory CD4 T cells are thought to contribute specifically to disease pathogenesis. Among these, functional imbalances in the frequencies of T regulatory cells (Tregs) and int...

journal_title：Journal of virology

authors： Lai SH,Starke CE,Flynn JK,Vinton CL,Ortiz AM,Mudd JC,Brenchley JM

更新日期：2019-04-17 00:00:00

abstract：:In the immunocompetent host, primary cytomegalovirus (CMV) infection is resolved by the immune response without causing overt disease. The viral genome, however, is not cleared but is maintained in a latent state that entails a risk of virus recurrence and consequent organ disease. By using murine CMV as a model, we h...

journal_title：Journal of virology

authors： Steffens HP,Kurz S,Holtappels R,Reddehase MJ

更新日期：1998-03-01 00:00:00

abstract：:The foot-and-mouth disease virus (FMDV) capsid is highly acid labile, but introduction of amino acid replacements, including an N17D change in VP1, can increase its acid resistance. Using mutant VP1 N17D as a starting point, we isolated a virus with higher acid resistance carrying an additional replacement, VP2 H145Y,...

journal_title：Journal of virology

authors： Vázquez-Calvo A,Caridi F,Sobrino F,Martín-Acebes MA

更新日期：2014-03-01 00:00:00

abstract：:Rhesus monkey rhadinovirus (RRV), a simian gamma-2 herpesvirus closely related to the Kaposi sarcoma-associated herpesvirus, replicates lytically in cultured rhesus monkey fibroblasts and establishes persistence in B cells. Overlapping cosmid clones were generated that encompass the entire 130-kilobase-pair genome of ...

journal_title：Journal of virology

authors： Bilello JP,Morgan JS,Damania B,Lang SM,Desrosiers RC

更新日期：2006-02-01 00:00:00

abstract：:A particles with the diameter of 70 to 80 nm were isolated from the cytoplasm of HEp-2, HeLa, and AO cells producing oncornavirus of Mason-Pfizer-like type. Most of the A particles banded at 1.23 to 1.24 g/ml, whereas 3 to 10% banded at 1.29 g/ml in equilibrium sucrose gradients. They banded at 1.30 g/ml in CsCl gradi...

journal_title：Journal of virology

authors： Bukrinskaya AG,Miller GG,Lebedeva EN,Agaphonova LV,Masurenko NN,Ilyin KV

更新日期：1974-10-01 00:00:00

abstract：:A contiguously linked T-B synthetic viral epitope (110HA120-150HA159,T-B) was investigated for its potency in inducing humoral and cellular immune responses in vivo. The T-cell epitope 110HA120 corresponds to the site 1 hemagglutinin (HA) of the A/PR/8/34 (PR8) influenza virus and is recognized by CD4 T cells in assoc...

journal_title：Journal of virology

authors： Brumeanu TD,Casares S,Bot A,Bot S,Bona CA

更新日期：1997-07-01 00:00:00

abstract：:The amount and distribution of viral DNA were established in a horse acutely infected with the Wyoming strain of equine infectious anemia virus (EIAV). The highest concentration of viral DNA were found in the liver, lymph nodes, bone marrow, and spleen. The kidney, choroid plexus, and peripheral blood leukocytes also ...

journal_title：Journal of virology

authors： Rice NR,Lequarre AS,Casey JW,Lahn S,Stephens RM,Edwards J

更新日期：1989-12-01 00:00:00