Excretion of mutagens, nicotine and its metabolites in urine of cigarette smokers.

abstract：:Well-established in vitro methods for testing the genotoxic potency of chemicals--such as the Ames/Salmonella test, the mouse lymphoma assay, the micronucleus test and the chromosomal aberration test--show a high false-positive rate for predicting in vivo genotoxicity and carcinogenicity. Thus, there is a need for mor...

journal_title：Mutagenesis

authors： Mathijs K,Brauers KJ,Jennen DG,Lizarraga D,Kleinjans JC,van Delft JH

更新日期：2010-11-01 00:00:00

abstract：:Non-cytotoxic concentrations (1.5, 3 and 6 microM) of sodium arsenite (SA) were used to study its cytogenetic effects with special reference to the frequency and nature of chromosomal aberrations on the X chromosome at Xq21 and at centromeric regions in CHO9, EM-C11, V79, V-H4 and CHE cell lines using Giemsa and FISH ...

journal_title：Mutagenesis

authors： Radha S,Natarajan AT

更新日期：1998-05-01 00:00:00

abstract：:This is a review of the work on molecular dosimetry carried out by several laboratories within the third Environmental Programme of the Commission of the European Communities. The molecular dosimetry project is a coordinated research project in which several laboratories cooperated on various aspects of quantitative c...

journal_title：Mutagenesis

authors： van Zeeland AA

更新日期：1988-05-01 00:00:00

abstract：:A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired G:T mismatches from spontaneous deamination of 5-methylcytosine at C...

journal_title：Mutagenesis

authors： Valentine CR,Rainey HF,Farrell JM,Shaddock JG,Dobrovolsky VN,Delongchamp RR

更新日期：2008-09-01 00:00:00

abstract：:Down syndrome (DS) is the most common chromosomal abnormality. Many studies have assessed the association between maternal gene polymorphisms involved in folate metabolism and the risk of having a DS offspring, but data are conflicting. Our study aimed to arrive at a more accurate estimation. Therefore, we carried out...

journal_title：Mutagenesis

authors： Yang M,Gong T,Lin X,Qi L,Guo Y,Cao Z,Shen M,Du Y

更新日期：2013-11-01 00:00:00

abstract：:The development of novel nanomaterials with unique physico-chemical properties is increasing at a rapid rate, with potential applications across a broad range of manufacturing industries and consumer products. Nanomaterial safety is therefore becoming an increasingly contentious issue that has intensified over the pas...

journal_title：Mutagenesis

authors： Doak SH,Griffiths SM,Manshian B,Singh N,Williams PM,Brown AP,Jenkins GJ

更新日期：2009-07-01 00:00:00

abstract：:FD&C Red No.3 (erythrosine) has been used as a dye in foods, drugs and cosmetics since its approval by the US Department of Agriculture in 1907. In 1977 the Certified Color Manufacturers' Association (CCMA) initiated studies on FD&C Red No.3 including chronic toxicity and carcinogenicity studies in rats and mice. Data...

journal_title：Mutagenesis

authors： Lin GH,Brusick DJ

更新日期：1986-07-01 00:00:00

abstract：:In this study, we determined the induction and time-dependent accumulation of micronuclei in the peripheral blood of transgenic C57BL/6 p53+/- mice (p53+/- mice), FVB/N Tg.AC v-Ha-ras mice (Tg.AC mice) and their isogenic parental strains, FVB/N and C57BL/6 following inhalation exposure to benzene. Our objective was to...

journal_title：Mutagenesis

authors： Healy LN,Pluta LJ,James RA,Janszen DB,Torous D,French JE,Recio L

更新日期：2001-03-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO), a well-known differentiation inducer in several myeloid cells, also induces a reversible G(1) arrest in many cell lines. We recently showed that DMSO induces a G(1) phase arrest in Chinese hamster ovary (CHO) cells, by restoring contact inhibition and preventing high density-dependent apopto...

journal_title：Mutagenesis

authors： Fiore M,Zanier R,Degrassi F

更新日期：2002-09-01 00:00:00

abstract：:A transgenic mouse strain with a high copy number of rescuable lacZ sequences was evaluated for its effectiveness in detecting lacZ- mutations in selected tissues. Procarbazine, cyclophosphamide, ethylnitrosourea, 7,12-dimethylbenz[a]anthracene (DMBA), acrylamide and chlorambucil were tested following either single or...

journal_title：Mutagenesis

authors： Hoorn AJ,Custer LL,Myhr BC,Brusick D,Gossen J,Vijg J

更新日期：1993-01-01 00:00:00

abstract：:Due to the very limited transduction capacity of hitherto available vectors, the success of gene therapy of tumours by means of suicide genes has so far essentially depended on the transfer of toxic drug metabolites from transduced (metabolizing) cells to adjacent non-transduced cells via gap junctions (bystander effe...

journal_title：Mutagenesis

authors： Thust R,Tomicic MT,Gräbner R,Friedrichs C,Wutzler P,Kaina B

更新日期：2004-01-01 00:00:00

abstract：:In order to discriminate between different mechanisms put forward to explain the low observed yields of reciprocal translocation configurations at diakinesis-metaphase I spermatocytes following treatment of mouse stem cell spermatogonia with chemical clastogens, the physiological states of stem cells at the moment of ...

journal_title：Mutagenesis

authors： van Buul PP,Seelen CM,Schöppink K,Goudzwaard JH

更新日期：1992-07-01 00:00:00

abstract：:In order to establish the capacity of Mytilus spp. to form genotoxin-DNA adducts, a series of in vitro and in vivo studies were conducted in which tissue samples and animals were exposed to five model genotoxins. Following the in vitro characterization of the major adducts induced by the compounds, a series of in vivo...

journal_title：Mutagenesis

authors： Harvey JS,Parry JM

更新日期：1997-05-01 00:00:00

abstract：:The nucleoside analog zidovudine (3'-azido-3'-deoxythymidine, AZT), by itself or in combination with other anti- retroviral drugs, is used perinatally to prevent mother to child transmission of human immunodeficiency virus type 1. AZT is mutagenic in vitro and mutagenic and carcinogenic when administered to neonatal m...

journal_title：Mutagenesis

authors： Von Tungeln LS,Dobrovolsky VN,Bishop ME,Shaddock JG,Heflich RH,Beland FA

更新日期：2004-07-01 00:00:00

abstract：:Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of underst...

journal_title：Mutagenesis

authors： Creton S,Aardema MJ,Carmichael PL,Harvey JS,Martin FL,Newbold RF,O'Donovan MR,Pant K,Poth A,Sakai A,Sasaki K,Scott AD,Schechtman LM,Shen RR,Tanaka N,Yasaei H

更新日期：2012-01-01 00:00:00

abstract：:Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other that is independent of these factors. Using a cell-free NHEJ assay, we...

journal_title：Mutagenesis

authors： Kuhfittig-Kulle S,Feldmann E,Odersky A,Kuliczkowska A,Goedecke W,Eggert A,Pfeiffer P

更新日期：2007-05-01 00:00:00

abstract：:The Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene had been implicated in cancer susceptibility. Studies investigating the associations between the Ser326Cys polymorphism and cancer susceptibility showed conflicting results. To derive a more precise estimation of the relationship, a meta...

journal_title：Mutagenesis

authors： Wang W,Wang M,Chen Y,Zhang Z,Wang S,Xu M,Wang B,Zhao Q,Zhang Z

更新日期：2012-05-01 00:00:00

abstract：:The aim of the present work was to investigate the possible interference of cytochalasin B (cyt B) with low concentration treatment with colchicine in the induction of chromosome/chromatid loss and micronuclei in human lymphocytes mitotically activated in vitro. Thus, cells from a single female donor were treated with...

journal_title：Mutagenesis

authors： Minissi S,Gustavino B,Degrassi F,Tanzarella C,Rizzoni M

更新日期：1999-01-01 00:00:00

abstract：:Eight widely used halogenated benzenes, including bromobenzene (BB), chlorobenzene (CB), three isomers of dichlorobenzene (DCB) and three isomers of trichlorobenzene (TCB) were tested for acute toxicity (LD50) and clastogenicity in 8-week-old NMRI mice by intraperitoneal administration. Four doses of each chemical (up...

journal_title：Mutagenesis

authors： Mohtashamipur E,Triebel R,Straeter H,Norpoth K

更新日期：1987-03-01 00:00:00

abstract：:The circulating human transcriptome, which includes both coding and non-coding RNA (ncRNA) molecules, represents a rich source of potential biomarkers for colorectal cancer (CRC) that has only recently been explored. In particular, the release of RNA-containing extracellular vesicles (EVs), in a multitude of different...

journal_title：Mutagenesis

authors： Francavilla A,Turoczi S,Tarallo S,Vodicka P,Pardini B,Naccarati A

更新日期：2020-07-11 00:00:00

abstract：:Primary liver fibroblasts were applied in a cytokinesis-block micronucleus assay in combination with fluorescence in situ hybridization (FISH) using two protocols. In protocol A (Prot. A), cytochalasin B (Cyt B) was added at the end of the treatment time directly to the medium containing the standard compounds, wherea...

journal_title：Mutagenesis

authors： Nesti C,Trippi F,Scarpato R,Migliore L,Turchi G

更新日期：2000-03-01 00:00:00

abstract：:Aneuploidy of mouse chromosome 8 induced by a Chinese medicinal herb, Tripterygium hypoglaucum (level) Hutch (THH) was investigated by fluorescence in situ hybridization (FISH) in vivo. Male mice were treated with THH (single i.p. injection) at doses of 120, 240 and 480 mg/kg. Colchicine (COL, 1.5 mg/kg i.p.) was used...

journal_title：Mutagenesis

authors： Xu W,Ziqing L,Yinrun D,Xiaoyan W,Jinglun X

更新日期：2004-09-01 00:00:00

abstract：:Genotoxic stress causes a reduced stability of the plant genome and has a detrimental effect on plant growth and productivity. Double-strand breaks (DSBs) are the most harmful of all DNA lesions because they cause the loss of genetic information on both strands of the DNA helix. In the presented study the coding and g...

journal_title：Mutagenesis

authors： Stolarek M,Gruszka D,Braszewska-Zalewska A,Maluszynski M

更新日期：2015-11-01 00:00:00

abstract：:In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S....

journal_title：Mutagenesis

authors： da Silva CR,Almeida GS,Caldeira-de-Araújo A,Leitão AC,de Pádula M

更新日期：2016-01-01 00:00:00

abstract：:The over-production of reactive oxygen species (ROS) can cause oxidative damage to a large number of molecules, including DNA, and has been associated with the pathogenesis of several disorders, such as diabetes mellitus (DM), dyslipidemia and periodontitis (PD). We hypothesise that the presence of these diseases coul...

journal_title：Mutagenesis

authors： Corbi SC,Bastos AS,Orrico SR,Secolin R,Dos Santos RA,Takahashi CS,Scarel-Caminaga RM

更新日期：2014-11-01 00:00:00

abstract：:On April 6, 1993, near the town of Tomsk (Russia) there was an accident at the Siberian Chemical Plant (SCP) which resulted in extensive contamination of an area of 250 km(2) to the north of SCP with long-lived radionuclides such as (239)Pu, (137)Cs and (90)Sr. Cytogenetic methods and electron spin resonance (ESR) spe...

journal_title：Mutagenesis

authors： Ilyinskikh NN,Ilyinskikh IN,Porovskiy VA,Natarajan AT,Suskov II,Smirenniy LN,Ilyinskikh EN

更新日期：1999-09-01 00:00:00

abstract：:Implementation of the seventh amendment to the EU Cosmetics Directive has driven much research into suitable in vitro alternative assays to support satisfactory risk assessments. One such assay is the reconstructed skin micronucleus (RSMN) assay. First reported in 2006, further development occurred and a standard prot...

journal_title：Mutagenesis

authors： Kidd D,Phillips S,Chirom T,Mason N,Smith R,Saul J,Whitwell J,Clements J

更新日期：2019-12-03 00:00:00

abstract：:1,8-Dinitropyrene (1,8-DNP) was clearly mutagenic at the hprt locus in CHO cells, but not detectably mutagenic in V79 cells, following a 3-h treatment period. Preliminary data indicate that CHO, but not V79, cells have measurable levels of N-acetyltransferase activity, and this may contribute to the differential sensi...

journal_title：Mutagenesis

authors： O'Donovan MR

更新日期：1990-05-01 00:00:00

abstract：:A collaborative study of interlaboratory variability in bacterial mutagenicity induced by mitomycin C (MMC) and bleomycin (BLM) was performed using the four strains Salmonella typhimurium TA102 and TA2638 and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101. Thirteen laboratories participated in this study. The four st...

journal_title：Mutagenesis

authors： Watanabe K,Sakamoto K,Sasaki T

更新日期：1995-05-01 00:00:00

abstract：:Colcemid (COM) and econazole (EZ) were tested for induction of mitotic arrest and C-mitotic effects in mouse bone marrow cells and for meiotic delay and induction of hyperploidy in mouse spermatocytes after single injection. Doses of 1 and 3 mg/kg COM were used and bone marrow and spermatocytes were sampled at 2, 6, 1...

journal_title：Mutagenesis

authors： Shi Q,Adler ID

更新日期：1998-07-01 00:00:00