Absence of translocation induction in mouse stem cell spermatogonia by chemical mutagens probably due to selective elimination.

abstract：:Photomutagenicity assays are required for regulatory submissions of some chemicals. As yet there are no well-validated protocols available for these assays. Critical factors which may contribute to the ability of a bacterial assay to detect photomutagens (e.g. dose of UV and test chemical, exposure conditions, light s...

journal_title：Mutagenesis

authors： Henderson L,Fedyk J,Bourner C,Windebank S,Fletcher S,Lovell W

更新日期：1994-09-01 00:00:00

abstract：:The over-production of reactive oxygen species (ROS) can cause oxidative damage to a large number of molecules, including DNA, and has been associated with the pathogenesis of several disorders, such as diabetes mellitus (DM), dyslipidemia and periodontitis (PD). We hypothesise that the presence of these diseases coul...

journal_title：Mutagenesis

authors： Corbi SC,Bastos AS,Orrico SR,Secolin R,Dos Santos RA,Takahashi CS,Scarel-Caminaga RM

更新日期：2014-11-01 00:00:00

abstract：:Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of underst...

journal_title：Mutagenesis

authors： Creton S,Aardema MJ,Carmichael PL,Harvey JS,Martin FL,Newbold RF,O'Donovan MR,Pant K,Poth A,Sakai A,Sasaki K,Scott AD,Schechtman LM,Shen RR,Tanaka N,Yasaei H

更新日期：2012-01-01 00:00:00

abstract：:In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S....

journal_title：Mutagenesis

authors： da Silva CR,Almeida GS,Caldeira-de-Araújo A,Leitão AC,de Pádula M

更新日期：2016-01-01 00:00:00

abstract：:Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP) with ozone were investigated. Male and female B6C3F1 mice were exposed to ozone (0.5 p.p.m.), NNK (1.0 mg/kg), DBP (5000 p.p.m.) and different combinations of these toxicants 6 h/day for 16,...

journal_title：Mutagenesis

authors： Kim MY,Kim YC,Cho MH

更新日期：2002-07-01 00:00:00

abstract：:The ability of topoisomerase II inhibitor, teniposide, to induce aneuploidy and meiotic delay in somatic and germinal cells of male mice was investigated by fluorescence in situ hybridisation (FISH) assay using labelled DNA probes and 5-bromo-2'-deoxyuridine (BrdU) incorporation assay, respectively. Colchicine and mit...

journal_title：Mutagenesis

authors： Attia SM

更新日期：2012-01-01 00:00:00

abstract：:The aim of the present work was to investigate the possible interference of cytochalasin B (cyt B) with low concentration treatment with colchicine in the induction of chromosome/chromatid loss and micronuclei in human lymphocytes mitotically activated in vitro. Thus, cells from a single female donor were treated with...

journal_title：Mutagenesis

authors： Minissi S,Gustavino B,Degrassi F,Tanzarella C,Rizzoni M

更新日期：1999-01-01 00:00:00

abstract：:Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a s...

journal_title：Mutagenesis

authors： Tomlinson IP,Houlston RS,Montgomery GW,Sieber OM,Dunlop MG

更新日期：2012-03-01 00:00:00

abstract：:A modified protocol is described for the in vitro analysis of micronuclei in whole blood or separated lymphocyte cultures. The induction of binucleate cells by various concentrations of cytochalasin B (3, 4.5 or 6 micrograms/ml) was examined at two harvest times (68 or 72 h). An optimal yield was obtained by adding cy...

journal_title：Mutagenesis

authors： Ellard S,Parry EM

更新日期：1993-07-01 00:00:00

abstract：:The dose effect between nucleoplasmic bridges (NPB) and relatively low doses of ionising radiation remains unknown. Accordingly, this study investigated the NPB frequencies in human peripheral blood lymphocytes exposed to low-dose (60)Co γ-rays. Complex anomalies, including fused nuclei (FUS), horse-shoe nuclei (HS) a...

journal_title：Mutagenesis

authors： Tian XL,Zhao H,Cai TJ,Lu X,Chen DQ,Li S,Liu QJ

更新日期：2016-07-01 00:00:00

abstract：:Down syndrome (DS) is the most common chromosomal abnormality. Many studies have assessed the association between maternal gene polymorphisms involved in folate metabolism and the risk of having a DS offspring, but data are conflicting. Our study aimed to arrive at a more accurate estimation. Therefore, we carried out...

journal_title：Mutagenesis

authors： Yang M,Gong T,Lin X,Qi L,Guo Y,Cao Z,Shen M,Du Y

更新日期：2013-11-01 00:00:00

abstract：:CASE, an artificial intelligence structure-activity relational system, was used to predict the carcinogenicity of a group of chemicals currently being tested in rodent bioassays by the US National Toxicology Program. The 'learning set' for the CASE predictions consisted of the results of previous 252 rodent carcinogen...

journal_title：Mutagenesis

authors： Rosenkranz HS,Klopman G

更新日期：1990-09-01 00:00:00

abstract：:It has been hypothesised that positive associations between age and levels of oxidative stress-generated damage to DNA may be related to an age-dependent decline in DNA repair activity. The objective of this study was to investigate the association between age and repair activity of oxidatively damaged DNA in peripher...

journal_title：Mutagenesis

authors： Løhr M,Jensen A,Eriksen L,Grønbæk M,Loft S,Møller P

更新日期：2015-09-01 00:00:00

abstract：:Urine samples from 26 cigarette smokers on a restricted diet were collected in the late afternoon. Urine extracts on XAD-2 resin were tested for mutagenicity in the microsuspension assay using Salmonella typhimurium strain TA98 in the presence of metabolizing and deconjugating enzymes. Levels of urinary nicotine plus ...

journal_title：Mutagenesis

authors： Granella M,Priante E,Nardini B,Bono R,Clonfero E

更新日期：1996-03-01 00:00:00

abstract：:The human FANCG/XRCC9 gene, which is defective in Fanconi anemia complementation group G (FA-G) cells, was first cloned by genetic complementation of the mitomycin C (MMC) sensitivity of CHO mutant UV40. The CHO NM3 mutant was subsequently assigned to the same complementation group. The parental AA8 CHO cells are hemi...

journal_title：Mutagenesis

authors： Lamerdin JE,Yamada NA,George JW,Souza B,Christian AT,Jones NJ,Thompson LH

更新日期：2004-05-01 00:00:00

abstract：:Five selectively methylated analogs of the flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) and of the nematocide 1,2-dibromo-3-chloropropane (DBCP) were synthesized and their relative mutagenicities determined in Salmonella typhimurium TA100 in the presence of rat liver microsomes. In all cases, methylation...

journal_title：Mutagenesis

authors： Omichinski JG,Søderlund EJ,Bausano JA,Dybing E,Nelson SD

更新日期：1987-07-01 00:00:00

abstract：:Quantitative and qualitative aspects of the in vivo micronucleus-inducing potential of five chemicals were studied using flow cytometric enumeration of micronucleated polychromatic peripheral blood erythrocytes in mice. The chemicals were hydroquinone, vinblastine sulphate, chloral hydrate (tested in two different mou...

journal_title：Mutagenesis

authors： Grawé J,Nüsse M,Adler ID

更新日期：1997-01-01 00:00:00

abstract：:The widespread production and use of nanoparticles calls for faster and more reliable methods to assess their safety. The main aim of this study was to investigate the genotoxicity of three reference TiO2 nanomaterials (NM) within the frame of the FP7-NANoREG project, with a particular focus on testing the applicabili...

journal_title：Mutagenesis

authors： Di Bucchianico S,Cappellini F,Le Bihanic F,Zhang Y,Dreij K,Karlsson HL

更新日期：2017-01-01 00:00:00

abstract：:Escherichia coli K12ND-160 possesses characteristics which make it highly suitable for studies on mutagenic/antimutagenic specificity and has been used to investigate such effects for several agents. Nitrofurazone (NFZ) was used as a mutagen at non-lethal concentrations; it causes mutation from fucose sensitivity to r...

journal_title：Mutagenesis

authors： Clarke CH,Shankel DM

更新日期：1989-01-01 00:00:00

abstract：:Fanconi anaemia (FA) is a rare autosomal recessive disease characterized by increased spontaneous and DNA crosslinker-induced chromosome instability, progressive pancytopenia and cancer susceptibility. An increasing number of genes are involved in FA, including the breast cancer susceptibility gene BRCA2. Five of the ...

journal_title：Mutagenesis

authors： Bogliolo M,Cabré O,Callén E,Castillo V,Creus A,Marcos R,Surrallés J

更新日期：2002-11-01 00:00:00

abstract：:Sister chromatid exchanges (SCE) and chromosome aberrations (CA) were studied in the lymphocytes of 70 male agricultural workers occupationally exposed to several pesticides and 69 matched controls, without indication of exposure to pesticides, from 'El Maresme' (Barcelona, Spain), Comparison between both groups revea...

journal_title：Mutagenesis

authors： Carbonell E,Xamena N,Creus A,Marcos R

更新日期：1993-11-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (MT) specific activity (fmol/mg protein) was measured in human T lymphocytes which were maintained as exponentially growing cultures from 6 to 17 days. The T lymphocytes were not transformed and were grown under the same conditions used previously for determination of spontaneous...

journal_title：Mutagenesis

authors： Bartlett JD,Robison SH

更新日期：1990-03-01 00:00:00

abstract：:Fanconi anaemia (FA) patients show cellular sensitivity to a variety of clastogens and prominently to cross-linking agents. Although there is a long-standing clinical impression of radiosensitivity, in vitro studies have yielded conflicting results. In this study, initial radiation-induced DNA damage and kinetics of D...

journal_title：Mutagenesis

authors： Mohseni-Meybodi A,Mozdarani H,Mozdarani S

更新日期：2009-01-01 00:00:00

abstract：:In the past decade, a number of case-control studies have been carried out to investigate the relationship between the HHEX polymorphism and type 2 diabetes (T2D). However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the rela...

journal_title：Mutagenesis

authors： Cai Y,Yi J,Ma Y,Fu D

更新日期：2011-03-01 00:00:00

abstract：:The adaptive response is a phenomenon by which cells exposed to low, non-cytotoxic doses of a genotoxicant become significantly resistant to a subsequent higher dose of the same or another genotoxic agent. Induction of the adaptive response has been mainly studied using ionizing radiation and alkylating agents as geno...

journal_title：Mutagenesis

authors： Oliveira NG,Rodrigues AS,Chaveca T,Rueff J

更新日期：1997-11-01 00:00:00

abstract：:Over the past several years, we have been evaluating the mutagenicity and clastogenicity of compounds capable of Michael-type reactions. These compounds, including acrylamide, several acrylate and methacrylate esters, vinyl sulfones, and phorone, have been evaluated using TK+/- -3.7.2C mouse lymphoma cells. Mutagenic ...

journal_title：Mutagenesis

authors： Dearfield KL,Harrington-Brock K,Doerr CL,Rabinowitz JR,Moore MM

更新日期：1991-11-01 00:00:00

abstract：:Isothiocyanates are plant-derived compounds that may be beneficial in the prevention of certain chronic diseases. Yet, by stimulating the production of reactive oxygen species (ROS), isothiocyanates can be genotoxic. Whether antioxidants influence isothiocyanate-induced genotoxicity is unclear, but this situation was ...

journal_title：Mutagenesis

authors： Hoffman JD,Ward WM,Loo G

更新日期：2015-05-01 00:00:00

abstract：:Cyclooxygenase 2 (Cox-2, a rate-limiting enzyme in the conversion of arachidonic acid to prostanoids) has been implicated in several physiological and pathological processes, and it has been reported that polymorphisms in the regulatory region of Cox-2 might influence its expression, contributing to the interindividua...

journal_title：Mutagenesis

authors： Tang Z,Nie ZL,Pan Y,Zhang L,Gao L,Zhang Q,Qu L,He B,Song G,Zhang Y,Shukui Wang

更新日期：2011-11-01 00:00:00

abstract：:Nitropyrenes are a class of polycyclic hydrocarbons that have been shown to be potent point mutagens in the Salmonella/mammalian microsome assay. However, relatively few data have been published on their ability to induce chromosome aberrations. In this paper we report the cytogenetic activity of 1-nitropyrene, 1-nitr...

journal_title：Mutagenesis

authors： Lafi A,Parry JM

更新日期：1987-01-01 00:00:00

abstract：:The development of novel nanomaterials with unique physico-chemical properties is increasing at a rapid rate, with potential applications across a broad range of manufacturing industries and consumer products. Nanomaterial safety is therefore becoming an increasingly contentious issue that has intensified over the pas...

journal_title：Mutagenesis

authors： Doak SH,Griffiths SM,Manshian B,Singh N,Williams PM,Brown AP,Jenkins GJ

更新日期：2009-07-01 00:00:00