ARDS. The future.

Abstract:

:Improving the course and outcome of patients with ARDS presents a considerable challenge. An important component of meeting this challenge is a more comprehensive understanding of the heterogeneous pathophysiology of ARDS and the biologic response of the individual patient. This understanding may be developed through the power of genomics and its related technology. In particular, it will be crucial to characterize the immunophenotypes of individual patients with ARDS. By understanding the immune status of a given patient at a given point in the disease process, physicians can consider manipulating proinflammatory systems more rationally, such as the complement and chemokine cascades, or the anti-inflammatory arm of the immune system. Finally, a more refined molecular and genetic understanding of endogenous cytoprotective molecules and mechanisms, such as the heat shock response and HO-1, may provide further tools in the future armamentarium against ARDS.

journal_name

Crit Care Clin

journal_title

Critical care clinics

authors

Wong HR

doi

10.1016/s0749-0704(03)00072-1

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

177-96

issue

1

eissn

0749-0704

issn

1557-8232

pii

S0749-0704(03)00072-1

journal_volume

18

pub_type

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