The pharmacotherapy of septic shock.

Abstract:

:Septic shock is a common clinical problem in the intensive care setting. The high mortality rate associated with septic shock, regardless of age, reflects the inadequacy of available therapeutic approaches. The purpose of this article is to review the current pharmacologic approaches to the treatment of septic shock with an emphasis on the pathophysiologic correlations of these treatments.

journal_name

Crit Care Clin

journal_title

Critical care clinics

authors

Boyd JL 3rd,Stanford GG,Chernow B

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

133-50

issue

1

eissn

0749-0704

issn

1557-8232

journal_volume

5

pub_type

杂志文章,评审
  • Bedside diagnostic ultrasound and therapeutic ultrasound-guided procedures in the intensive care setting.

    abstract::The availability, portability, safety, and other features of ultrasound have ushered this relatively new imaging modality into the everyday clinical practice of multiple disciplines. Features unique to ultrasound lend this imaging modality the opportunity for extensive use in the ICU. A review of its uses in this capa...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0749-0704(05)70097-x

    authors: Beagle GL

    更新日期:2000-01-01 00:00:00

  • Traumatic Brain Injury Advances.

    abstract::There have been many recent advances in the management of traumatic brain injury (TBI). Research regarding established and novel therapies is ongoing. Future research must not only focus on development of new strategies but determine the long-term benefits or disadvantages of current strategies. In addition, the impac...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2016.08.008

    authors: Stein DM,Feather CB,Napolitano LM

    更新日期:2017-01-01 00:00:00

  • Rehabilitation in spinal cord injury.

    abstract::Caring for the new quadriplegic is an immense undertaking involving multiple health care professionals who must function as a team. The physician in charge must understand rehabilitation principles and be able to communicate with all members of the team caring for the patient. Rehabilitation principles, if considered ...

    journal_title:Critical care clinics

    pub_type: 杂志文章

    doi:

    authors: Keppler JP

    更新日期:1987-07-01 00:00:00

  • Arthritis in the intensive care unit.

    abstract::Acute arthritis in critically ill patients may be caused by local or systemic infection, by a flare of chronic joint disease such as rheumatoid or crystal-associated arthritis, or by less common entities such as hemarthrosis. Diagnosis requires analysis of synovial fluid, and appropriate treatment is based on its find...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0749-0704(02)00021-0

    authors: Raj JM,Sudhakar S,Sems K,Carlson RW

    更新日期:2002-10-01 00:00:00

  • The role of the fiberscope in the critically ill patient.

    abstract::The role of the fiberscope in the management of difficult and failed intubations has been well established and the importance of learning this valuable skill has been emphasized. Nonetheless, the fiberscope is underutilized in anesthesia and critical care practices because of a high rate of intubation failure. The mai...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Ovassapian A,Randel GI

    更新日期:1995-01-01 00:00:00

  • Using severity measures to describe high performance intensive care units.

    abstract::This article describes the use of various scores and probabilities to clinically categorize patients in the adult intensive care unit. Some of the limitations of these severity measures are reviewed including variable definitions, timing of measurements, and whether models can be used for individual patients. Also, th...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Teres D,Lemeshow S

    更新日期:1993-07-01 00:00:00

  • Nursing the chronically critically ill patient.

    abstract::The provision of care to the CCI patient is complex, challenging, and unique. The advanced practice nursing model at Mount Sinai Hospital is one successful care delivery model that fills the needs of both CCI patients and the nurses who work with them. The following transferable aspects of the RCU add to the unit's su...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0749-0704(02)00008-8

    authors: Carasa M,Nespoli G

    更新日期:2002-07-01 00:00:00

  • Acute lung injury and acute respiratory distress syndrome in pregnancy.

    abstract::Acute respiratory failure can be the result of a variety of clinical conditions, such as congestive heart failure, pneumonia, pulmonary embolism, exacerbation of obstructive lung diseases, and acute respiratory distress syndrome (ARDS). This article focuses on developments related to acute lung injury and ARDS and rev...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2004.05.010

    authors: Bandi VD,Munnur U,Matthay MA

    更新日期:2004-10-01 00:00:00

  • Detection and management of pre-existing cognitive impairment and associated behavioral symptoms in the Intensive Care Unit.

    abstract::Recent increase in both the elderly population and associated incidence of dementia are of critical importance to patient care in ICUs in the United States. Identification of pre-existing cognitive impairment, such as mild cognitive impairment and dementia, could prevent delirium and associated morbidity and mortality...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2008.05.006

    authors: Lee HB,DeLoatch CJ,Cho S,Rosenberg P,Mears SC,Sieber FE

    更新日期:2008-10-01 00:00:00

  • Early Extubation in Enhanced Recovery from Cardiac Surgery.

    abstract::Prolonged intubation and mechanical ventilation following cardiac surgery have been associated with increased hospital and intensive care unit length of stays; higher health care costs; and morbidity resulting from atelectasis, intrapulmonary shunting, and pneumonia. Early extubation was developed as a strategy in the...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2020.06.005

    authors: McCarthy C,Fletcher N

    更新日期:2020-10-01 00:00:00

  • Hemodynamic resuscitation.

    abstract::Hemodynamic resuscitation for hemorrhagic shock should be directed toward optimizing oxygen delivery to the tissues. A combination of volume restoration and inotropic support usually is needed. This article identifies the basis and strategies necessary for accomplishing these goals. ...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Domsky MF,Wilson RF

    更新日期:1993-10-01 00:00:00

  • Complications of chronic liver disease.

    abstract::The patient with advanced cirrhosis presents unique challenges to the critical care physician, in great measure because of the protean functions attributable to the liver and the multiplicity of derangements that may occur. Portal hypertension, once it develops, is the source of potentially devastating complications t...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Chung RT,Jaffe DL,Friedman LS

    更新日期:1995-04-01 00:00:00

  • Automatic border detection and three-dimensional reconstruction with echocardiography.

    abstract::This article reviews two important innovations in echocardiography resulting from the recent advances in the capabilities of microprocessors. The first, automatic endocardial border detection, has been implemented on computers contained entirely within echocardiograph machines and is gaining wide clinical use. The sec...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0749-0704(05)70256-6

    authors: Legget ME,Bashein G

    更新日期:1996-04-01 00:00:00

  • Biowarfare and bioterrorism.

    abstract::Bioterrorism is not only a reality of the times in which we live but bioweapons have been used for centuries. Critical care physicians play a major role in the recognition of and response to a bioterrorism attack. Critical care clinicians must be familiar with the diagnosis and management of the most likely bioterrori...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2013.03.015

    authors: Christian MD

    更新日期:2013-07-01 00:00:00

  • Methods for monitoring the level of sedation.

    abstract::Sedative drugs commonly are titrated to effect in critically ill patients. Subjective clinical assessment tools are used to determine the patient's level of sedation, and there clearly is a need for improved quantitative methods of monitoring sedation. This article describes the current methods for assessing the level...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Avramov MN,White PF

    更新日期:1995-10-01 00:00:00

  • Septic shock.

    abstract::Although our understanding of molecular events in septic shock is growing exponentially, bedside management has changed only incrementally over the last 20 years. In pediatric and adult patients alike, treatment continues to be largely supportive. Morbidity and mortality, though gradually improving, continue to be hig...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0749-0704(05)70328-6

    authors: Carcillo JA,Cunnion RE

    更新日期:1997-07-01 00:00:00

  • Mean arterial pressure: therapeutic goals and pharmacologic support.

    abstract::The Surviving Sepsis Campaign targets central venous pressure, mean arterial pressure, and central venous oxygen saturation as guides for resuscitation. Fluid resuscitation and the use of vasopressors are paramount to the success of the campaign's end points. Although the achievement of supranormal physiologic paramet...

    journal_title:Critical care clinics

    pub_type: 杂志文章

    doi:10.1016/j.ccc.2009.12.005

    authors: Shapiro DS,Loiacono LA

    更新日期:2010-04-01 00:00:00

  • Immune Activation in Sepsis.

    abstract::Sepsis is caused by a dysregulated host response to infection. Immune responses determine the characteristics of sepsis. The body's protection against infection involves danger signal surveillance and recognition from nonself, effector functions in response to sensing danger signals, homeostatic regulation, and genera...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2017.08.002

    authors: Conway-Morris A,Wilson J,Shankar-Hari M

    更新日期:2018-01-01 00:00:00

  • Weaning from mechanical ventilation.

    abstract::Approximately 20% of all mechanically ventilated patients fail their first attempt to wean. Prolonged mechanical ventilation increases morbidity, mortality, and costs. No single weaning parameter predicts patient ability to wean. Weaning studies suggest that daily trials of spontaneous breathing for appropriate patien...

    journal_title:Critical care clinics

    pub_type: 杂志文章

    doi:10.1016/j.ccc.2006.12.002

    authors: Eskandar N,Apostolakos MJ

    更新日期:2007-04-01 00:00:00

  • Pediatric Extracorporeal Membrane Oxygenation.

    abstract::Extracorporeal life support is a modified form of cardiopulmonary bypass. Experience in extracorporeal membrane oxygenation (ECMO) has come largely from the neonatal population. Most centers have transitioned the ECMO pumps from roller pumps to centrifugal technology. Modes of support include venovenous for respirator...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2017.06.005

    authors: Jenks CL,Raman L,Dalton HJ

    更新日期:2017-10-01 00:00:00

  • Acute respiratory failure.

    abstract::Acute respiratory failure is common in critically ill children, who are at increased risk of respiratory embarrassment because of the developmental variations in the respiratory system. Although multiple etiologies exist, pneumonia and bronchiolitis are most common. Respiratory system monitoring has evolved, with the ...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2012.12.004

    authors: Schneider J,Sweberg T

    更新日期:2013-04-01 00:00:00

  • Trigger Criteria: Big Data.

    abstract::Electronic medical records can be used to mine clinical data (big data), providing automated analysis during patient care. This article describes the source and potential impact of big data analysis on risk stratification and early detection of deterioration. It compares use of big data analysis with existing methods ...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2017.12.007

    authors: Wong Lama KM,DeVita MA

    更新日期:2018-04-01 00:00:00

  • Parenteral nutrition in critical illness: can it safely improve outcomes?

    abstract::Total parenteral nutrition was developed in the 1960s and has since been implemented commonly in the intensive care unit (ICU). Studies published in the 1980s and early 1990s indicate that the use of total parenteral nutrition is associated with increased mortality and infectious morbidity. These detrimental effects w...

    journal_title:Critical care clinics

    pub_type: 杂志文章

    doi:10.1016/j.ccc.2010.04.002

    authors: Thibault R,Pichard C

    更新日期:2010-07-01 00:00:00

  • Historical aspects of critical care and the nervous system.

    abstract::The appropriate starting point for a history of neurocritical care is a matter of debate, and the organization of facts and conjectures about it must be somewhat arbitrary. Intensive care for neurosurgical patients dates back to the work of Walter Dandy at the Johns Hopkins Hospital in the 1930s; many consider his cre...

    journal_title:Critical care clinics

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.ccc.2008.12.004

    authors: Bleck TP

    更新日期:2009-01-01 00:00:00

  • Does value-based purchasing enhance quality of care and patient outcomes in the ICU?

    abstract::As health care expenditures increase, payers, including the Centers for Medicare and Medicaid Services, are moving away from reimbursement based on types and volume of services to an emphasis on quality of provided care, an approach called value-based purchasing (VBP). Because it is tied to reimbursement, VBP creates ...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2012.10.002

    authors: O'Brien JM Jr,Kumar A,Metersky ML

    更新日期:2013-01-01 00:00:00

  • History, general overview, and protection of health care workers.

    abstract::This article provides a background so that the intensivist can appreciate the social and cultural context in which the AIDS epidemic developed. The upheaval that AIDS has caused in the gay community is described along with some of the economic effects AIDS has had on that population and on the practice of medicine, bo...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Greenbaum DM

    更新日期:1993-01-01 00:00:00

  • Acute metabolic acid-base disorders.

    abstract::Metabolic acid-base disturbances commonly and predictably complicate the course of many intensive care unit patients and plague the intensivists, surgeons, and anesthesiologists beset with the task of caring for them. In this article, we offer a systematic approach to the patient with the metabolic acid-base disorders...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Riley LJ Jr,Ilson BE,Narins RG

    更新日期:1987-10-01 00:00:00

  • An introduction to ultrasound equipment and knobology.

    abstract::The use of ultrasonography in medical practice has evolved dramatically over the last few decades and will continue to improve as technological advances are incorporated into daily medical practice. Although ultrasound machine size and equipment have evolved, the basic principles and fundamental functions have remaine...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2013.08.006

    authors: Enriquez JL,Wu TS

    更新日期:2014-01-01 00:00:00

  • Avoiding Respiratory and Peripheral Muscle Injury During Mechanical Ventilation: Diaphragm-Protective Ventilation and Early Mobilization.

    abstract::Both limb muscle weakness and respiratory muscle weakness are exceedingly common in critically ill patients. Respiratory muscle weakness prolongs ventilator dependence, predisposing to nosocomial complications and death. Limb muscle weakness persists for months after discharge from intensive care and results in poor l...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2018.03.005

    authors: Schreiber A,Bertoni M,Goligher EC

    更新日期:2018-07-01 00:00:00

  • The use of daptomycin for Staphylococcus aureus infections in critical care medicine.

    abstract::The proliferation of methicillin-resistant Staphylococcus aureus (MRSA) and the severity of nosocomial critical care infections necessitate the development of viable alternative therapies. An increase in the tolerance of MRSA to the activity of vancomycin and to the associated suboptimal therapeutic measures is of par...

    journal_title:Critical care clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ccc.2007.12.010

    authors: Alder J

    更新日期:2008-04-01 00:00:00