Abstract：
:Both limb muscle weakness and respiratory muscle weakness are exceedingly common in critically ill patients. Respiratory muscle weakness prolongs ventilator dependence, predisposing to nosocomial complications and death. Limb muscle weakness persists for months after discharge from intensive care and results in poor long-term functional status and quality of life. Major mechanisms of muscle injury include critical illness polymyoneuropathy, sepsis, pharmacologic exposures, metabolic derangements, and excessive muscle loading and unloading. The diaphragm may become weak because of excessive unloading (leading to atrophy) or because of excessive loading (either concentric or eccentric) owing to insufficient ventilator assistance.
journal_name
Crit Care Clinjournal_title
Critical care clinicsauthors
Schreiber A,Bertoni M,Goligher ECdoi
10.1016/j.ccc.2018.03.005subject
Has Abstractpub_date
2018-07-01 00:00:00pages
357-381issue
3eissn
0749-0704issn
1557-8232pii
S0749-0704(18)30682-1journal_volume
34pub_type
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journal_title：Critical care clinics
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