Vasodilators in mechanical ventilation.

Abstract:

:Vasodilators that affect the pulmonary vasculature are appealing adjuncts in many cardiopulmonary conditions that require mechanical ventilation such as ARDS, COPD, PPHN, and cardiothoracic surgery. The adverse systemic effects of parenteral PGE1 and parenteral prostacyclin limit their usefulness in critically ill patients. Liposomal PGE1 has few systemic effects, but thus far has not resulted in a significant clinical benefit in patients with ARDS. Inhaled NO and aerosolized prostacyclin offer the advantage of selective pulmonary vasodilation with minimal systemic effects. Both agents decrease PAP and in many clinical situations improve oxygenation; however, the physiologic effects of inhaled NO and aerosolized prostacyclin have not convincingly led to improved clinical outcomes. Currently, use of vasodilators in mechanically ventilated patients remains investigational.

journal_name

Crit Care Clin

journal_title

Critical care clinics

authors

Zimmerman JL,Hanania NA

doi

10.1016/s0749-0704(05)70023-3

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

611-27

issue

4

eissn

0749-0704

issn

1557-8232

pii

S0749-0704(05)70023-3

journal_volume

14

pub_type

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