Anti-Mycoplasma pneumoniae secretory antibody in human breast milk.

Abstract:

:The secretory antibody responses to M. pneumoniae polypeptides were assessed among human breast milk samples. M. pneumoniae polypeptides were resolved with conventional SDS-PAGE, and antibody responses were determined by immunoblotting. Antibodies that contained secretory component were found to recognize antigens of 200, 185, 170, 150, 135, 92, 85, 60, 43, 27, and 24 kDa (M(r)). Among the latter, antigens of 170, 150, 60, and 43 kDa were recognized from the majority. Although these antibody binding sites parallel those that are also generally recognized by human sera when equivalent antigen is used, the high frequency (80%) of 150 kDa antigen recognition is not common for serum responses. This antigen should be further explored for its potential in future assessments of component vaccines.

authors

Macadam S,Cimolai N

doi

10.1016/s0732-8893(02)00396-6

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

247-50

issue

3

eissn

0732-8893

issn

1879-0070

pii

S0732889302003966

journal_volume

43

pub_type

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