Malignant hemangioendothelioma.

Abstract:

BACKGROUND:The administration of interleukin-2 (IL-2) has recently been reported to be favorable for treating malignant hemangioendothelioma (MHE). METHODS:Two patients with MHE responded well to intralesional injections of recombinant IL-2 (rIL-2) without major side effects. The purpose of this study was to characterize cells infiltrating the regressing tumor following rIL-2 treatment. Immunohistochemical studies were performed on biopsy specimens taken from rIL-2-injected lesional skin. RESULTS:It was shown that CD8+ lymphocytes and CD56+ natural killer (NK) cells infiltrated at the rIL-2-injection sites, suggesting that these cells contributed to the tumor regression. In addition, MHE cells bore intercellular adhesion molecule-1 (ICAM-1) whose expression was augmented by rIL-2 injections. CONCLUSIONS:These findings suggested, that rIL-2 not only induces lymphokine-activated killer (LAK) cells and NK cells, but also facilitates these cytotoxic cells to adhere to MHE cells by enhancing ICAM-1 expression of tumor cells.

journal_name

Int J Dermatol

authors

Ihda H,Tokura Y,Fushimi M,Yokote R,Hashizume H,Shirahama S,Iwatsuki K,Murakami K,Takigawa M

doi

10.1111/j.1365-4362.1995.tb04406.x

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

811-6

issue

11

eissn

0011-9059

issn

1365-4632

journal_volume

34

pub_type

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