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Parturitional factors associated with membrane stripping.

Abstract：

OBJECTIVE:Our purpose was to determine what factors occurring after digital separation of the chorionic membranes from the lower uterine segment (membrane stripping) are involved in observed clinical changes compared with patients not so treated. STUDY DESIGN:Thirty patients were randomly divided among a study population and two control groups to assess uterine contractions and microbiologic, histologic, and biochemical markers associated with parturitional events over a 7-hour time frame. RESULTS:Clinically, an increased frequency of uterine contractile activity was observed among patients in the membrane-stripped group (p < 0.03). There was a significant increase in plasma 13,14-dihydro-15-keto-prostaglandin F2 alpha (p < 0.001) and endocervical phospholipase A2 activity (p < 0.04) among those who underwent membrane stripping. Blood leukocyte counts, sedimentation rates, prostaglandin E2 metabolite concentrations, and fibronectin levels revealed no significant change during the 7-hour study session. CONCLUSION:Membrane stripping was associated with increases in phospholipase A2 activity and prostaglandin F2 alpha concentrations, indicating a possible correlation with initiation of the cascade of parturitional events.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

McColgin SW,Bennett WA,Roach H,Cowan BD,Martin JN Jr,Morrison JC

doi

10.1016/0002-9378(93)90134-5

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

71-7

issue

1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(93)90134-5

journal_volume

169

pub_type

临床试验,杂志文章,随机对照试验

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