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Postirradiation squamous cell carcinoma in situ of the vagina: treatment by topical 20 percent 5-fluorouracil cream.

Abstract：

:Eight patients with squamous cell carcinoma in situ of the vagina were treated with monthly 5 day courses of 20% 5-fluorouracil cream applied to the vagina. Seven (87.5%) of the women had an initial complete response; however, three subsequently developed recurrence after the treatment was stopped. They were retreated, and two of these three patients achieved a subsequent complete response. The overall response to therapy was 75% (6/8) with six women off therapy from 1.1 to 6.9 years. Total follow-up of all patients was 3.1 to 6.9 years with no patients having developed invasive carcinoma. Because of the high success rate with no associated serous sequelae, this is believed to be a satisfactory method of therapy for women with squamous cell carcinoma in situ of the vagina occurring after pelvic irradiation.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Piver MS,Barlow JJ,Tsukada Y,Gamarra M,Sandecki A

doi

10.1016/0002-9378(79)90709-9

subject

Has Abstract

pub_date

1979-10-01 00:00:00

pages

377-80

issue

3

eissn

0002-9378

issn

1097-6868

pii

0002-9378(79)90709-9

journal_volume

135

pub_type

杂志文章

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