当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Ripening of the human uterine cervix related to changes in collagen, glycosaminoglycans, and collagenolytic activity.

Ripening of the human uterine cervix related to changes in collagen, glycosaminoglycans, and collagenolytic activity.

Abstract：

:Connective tissue in biopsy specimens taken from the lower part of the uterine cervix in 40 pregnant women at various gestational ages was compared to that in similar biopsy specimens from 15 nonpregnant women. The concentrations of collagen, sulfated glycosaminoglycans, and hyaluronic acid decreased during pregnancy. At the gestational age of 10 weeks, the collagen concentration was 70%, and at term 30%, of that in the nonpregnant cervix. After delivery, no further decrease was observed. The extractability of collagen increased during pregnancy, as well as during labor. Also, the water concentration increased. An increase in the collagenolytic activity was observed with advancing gestational age. The 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gin-D-Arg hydrolytic activity (collagenase) and the concentration of leukocyte elastase increased gradually by a factor of 10. The physiologic importance of the collagen was also demonstrated, since the cervical dilatation time during spontaneous labor was long in women with high concentrations of collagen and short in women with low concentrations of collagen.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Uldbjerg N,Ekman G,Malmström A,Olsson K,Ulmsten U

doi

10.1016/0002-9378(83)90446-5

subject

Has Abstract

pub_date

1983-11-15 00:00:00

pages

662-6

issue

6

eissn

0002-9378

issn

1097-6868

pii

0002-9378(83)90446-5

journal_volume

147

pub_type

杂志文章

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