Maternal floor infarction: relationship to X cells, major basic protein, and adverse perinatal outcome.

Abstract:

OBJECTIVE:Maternal floor infarction of the placenta is characterized by gross placental abnormalities and histologic evidence of X-cell proliferation. Previously, pregnancy-associated major basic protein has been localized to the placental X cell and identified at elevated levels in serum and amniotic fluid in all normal pregnancies. Here we test the hypothesis that pregnancy-associated major basic protein is localized to the X cells in maternal floor infarction and that it contributes to the pathophysiologic features of pregnancies complicated by maternal floor infarction. STUDY DESIGN:Seven patients with eight pregnancies complicated by maternal floor infarction were evaluated. We analyzed placental tissue, serum, amniotic fluid, and placental cyst fluid for pregnancy-associated major basic protein. RESULTS:Placental tissue from pregnancies complicated by maternal floor infarction had increased numbers of X cells and fibrinoid material that occupied or surrounded degenerating villi and that stained intensely for pregnancy-associated major basic protein. Serum pregnancy-associated major basic protein levels were variable and likely cannot be used to predict the occurrence of maternal floor infarction. CONCLUSION:Pregnancy-associated major basic protein, a potent cytotoxin, is localized to X cells and is deposited in close proximity to chorionic villi in maternal floor infarction and may contribute to the pathophysiology of this disorder.

journal_name

Am J Obstet Gynecol

authors

Vernof KK,Benirschke K,Kephart GM,Wasmoen TL,Gleich GJ

doi

10.1016/s0002-9378(11)91716-5

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

1355-63

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)91716-5

journal_volume

167

pub_type

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