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Laparoscopic salpingostomy versus laparoscopic local methotrexate injection in the management of unruptured ectopic gestation.

Abstract：

OBJECTIVE:Our goal was to determine whether laparoscopic salpingostomy is preferable to laparoscopic methotrexate injection in the management of unruptured tubal gestation. STUDY DESIGN:Forty-eight patients with unruptured tubal pregnancy were prospectively randomized to either laparoscopic salpingostomy or laparoscopic local methotrexate injection in a university medical center. Operation time, duration of hospital stay, decrease in levels of beta-human chorionic gonadotropin, and fertility outcome were compared between the two groups. RESULTS:The salpingostomy group had a longer operative time (p < 0.0001) but a shorter hospital stay (p < 0.01) and a lower incidence of persistent trophoblastic activity (5% vs 14%), although this difference did not reach statistical significance. The time interval until beta-human chorionic gonadotropin disappearance was similar (13.9 and 13.7 days), and the subsequent intrauterine pregnancy rate was similar in the two groups (83.5% and 81%). One repeat tubal pregnancy occurred in the salpingostomy group. CONCLUSIONS:Both these methods of conservative management are equally effective and each one has its merits.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Zilber U,Pansky M,Bukovsky I,Golan A

doi

10.1053/ob.1996.v175.a74249

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

600-2

issue

3 Pt 1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(96)00490-5

journal_volume

175

pub_type

临床试验,杂志文章,随机对照试验

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