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A pilot study of intravenous ondansetron for hyperemesis gravidarum.

Abstract：

OBJECTIVE:We attempted to determine whether the antiemetic ondansetron would be more effective than promethazine in treating hyperemesis gravidarum. STUDY DESIGN:Patients with hyperemesis gravidarum who required hospital admission were randomized to receive either intravenous ondansetron (n = 15) or intravenous promethazine (n = 15) in a double-blind manner. Severity of disease was determined by electrolyte status, weight loss, ketonuria, and prior use of outpatient antiemetics. Outcome variables included degree of nausea, weight gain during treatment, days of hospitalization, and number of medication doses. RESULTS:In this preliminary investigation ondansetron offered no advantage when compared with promethazine in the relief of nausea, weight gain, days of hospitalization (4.5 +/- 2.3 vs 4.5 +/- 1.5), and total doses of medication per hospitalization (2.1 +/- 1.2 vs 1.9 +/- 1.3). CONCLUSION:This preliminary trial of ondansetron demonstrated no benefit over promethazine in patients hospitalized for hyperemesis gravidarum.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Sullivan CA,Johnson CA,Roach H,Martin RW,Stewart DK,Morrison JC

doi

10.1016/s0002-9378(96)70607-5

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

1565-8

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(96)70607-5

journal_volume

174

pub_type

临床试验,杂志文章,随机对照试验

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