Nighttime delivery and risk of neonatal encephalopathy.

Abstract:

OBJECTIVE:The objective of the study was to determine the relationship between nighttime delivery and neonatal encephalopathy (NE). STUDY DESIGN:The design of the study was a retrospective population-based cohort of 1,864,766 newborns at a gestation of 36 weeks or longer in California, 1999-2002. We determined the risk of NE associated with nighttime delivery (7:00 (PM) to 6:59 (AM)). RESULTS:Two thousand one hundred thirty-one patients had NE (incidence 1.1 per 1000 births). Nighttime delivery was associated with increased NE (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.03-1.20), birth asphyxia (OR, 1.18; 95% CI, 1.08-1.29), and neonatal seizures (OR, 1.17; 95% CI, 1.07-1.28). In adjusted analyses, nighttime delivery was an independent risk factor for NE (OR, 1.10; 95% CI, 1.01-1.21), as were severe intrauterine growth retardation (OR, 3.8; 95% CI, 3.1-4.8); no prenatal care (OR, 2.0; 95% CI, 1.4-2.9); primiparity (OR, 1.5; 95% CI, 1.4-1.7); advanced maternal age (OR, 1.3; 95% CI, 1.16-1.45); and infant male sex (OR, 1.3; 95% CI, 1.2-1.4). CONCLUSION:Future studies of time of delivery may generate new strategies to reduce the burden of NE.

journal_name

Am J Obstet Gynecol

authors

Wu YW,Pham TN,Danielsen B,Towner D,Smith L,Johnston SC

doi

10.1016/j.ajog.2010.09.022

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

37.e1-6

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(10)01168-3

journal_volume

204

pub_type

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