Abstract:
:We present a quantitative analysis of the visual response properties of single neurons in the dorsal lateral geniculate nucleus (dLGN) of wild-type C57Bl/6J mice. Extracellular recordings were made from single dLGN cells in mice under halothane and nitrous oxide anesthesia. After mapping the receptive fields (RFs) of these cells using reverse correlation of responses to flashed square stimuli, we used sinusoidal gratings to describe their linearity of spatial summation, spatial frequency tuning, temporal frequency tuning, and contrast response characteristics. All cells in our sample had RFs dominated by a single, roughly circular "center" mechanism that responded to either increases (ON-center) or decreases (OFF-center) in stimulus luminance, and almost all cells passed a modified null test for linearity of spatial summation. A difference of Gaussians model was used to relate spatial frequency tuning to the spatial properties of cells' RFs, revealing that mouse dLGN cells have large RFs (center diameter approximately 11 degrees) and correspondingly poor spatial resolution (approximately 0.2c/degree). Temporally, most cells in the mouse dLGN respond best to stimuli of approximately 4 Hz. We looked for evidence of parallel processing in the mouse dLGN and found it only in a functional difference between ON- and OFF-center cells: ON-center cells were more sensitive to stimulus contrast than their OFF-center neighbors.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Grubb MS,Thompson IDdoi
10.1152/jn.00699.2003subject
Has Abstractpub_date
2003-12-01 00:00:00pages
3594-607issue
6eissn
0022-3077issn
1522-1598pii
00699.2003journal_volume
90pub_type
杂志文章abstract::Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion. J. Neurophysiol. 78: 2811-2816, 1997. When we glance between objects, the brain ultimately controls gaze direction in space. However, it is currently unclear how this is allocated into separat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.5.2811
更新日期:1997-11-01 00:00:00
abstract::1. We examined the activity of thermally sensitive trigeminothalamic neurons and nonprojection neurons in the medullary dorsal horn (trigeminal nucleus caudalis) in three monkeys performing thermal and visual detection tasks. 2. An examination of neuronal stimulus-response functions, obtained during thermal-detection ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.62.2.437
更新日期:1989-08-01 00:00:00
abstract::Adaptation of movement may be driven by the difference between planned and actual motor performance, or the difference between expected and actual sensory consequences of movement. To identify how the nervous system differentially uses these signals, we asked: does motor adaptation occur when movement errors are irrel...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00273.2011
更新日期:2012-02-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00134.2014
更新日期:2014-10-15 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.6.3107
更新日期:1997-12-01 00:00:00
abstract::1. Neuronal responses to cutaneous and noncutaneous stimulation were examined in the hindlimb representation of the precentral motor cortex (MI) and the first somatosensory cortex (SI) of unanesthetized monkeys. 2. MI can be divided into two distinct parts of the basis of its afferent input. The rostral part receives ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1981.45.3.467
更新日期:1981-03-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00503.2020
更新日期:2020-12-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.3.1427
更新日期:1998-09-01 00:00:00
abstract::Activation of muscarinic receptors and GABA(B) receptors causes presynaptic inhibition of glutamatergic synaptic potentials at excitatory feedback connections in cortical structures. These effects may regulate dynamics in cortical structures, with presynaptic inhibition allowing extrinsic afferent input to dominate du...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.4.1792
更新日期:2001-10-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.4.1322
更新日期:1988-10-01 00:00:00
abstract::Saccade adaptation is a mechanism that adjusts saccade landing positions if they systematically fail to reach their intended target. In the laboratory, saccades can be shortened or lengthened if the saccade target is displaced during execution of the saccade. In this study, saccades were performed from different posit...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00743.2012
更新日期:2013-04-01 00:00:00
abstract::1. The electrical threshold of the terminations of single group Ia and II afferent fibers was transiently reduced by the antidromic discharge of the initial segment of spinal motoneurons in the cat. 2. This depolarization of the terminals of afferent fibers known to synapse on motoneurons confirms previous observation...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1979.42.3.635
更新日期:1979-05-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.2.447
更新日期:1999-02-01 00:00:00
abstract::The effect of a conditioning depolarizing current pulse (80-200 micros) on quantal secretion evoked by a similar test pulse at another site was examined in visualized motor-nerve terminal branches of amphibian endplates (Bufo marinus). Tetrodotoxin (200 nM) and cadmium (50 microM) were used to block voltage-dependent ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.3.1135
更新日期:1999-03-01 00:00:00
abstract::Numerous developmental changes in the nervous system occur during the first several weeks of the rodent lifespan. Therefore, many characteristics of neuronal function described at the cellular level from in vitro slice experiments conducted during this early time period may not generalize to adult ages. We investigate...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00756.2012
更新日期:2013-03-01 00:00:00
abstract::Unitary discharge patterns (peristimulus time histograms or PSTH) and synaptic events were studies with intracellular recording techniques in 164 cat cochlear nucleus cells to steady-frequency tone bursts 250 ms in duration. There were four response types defined on the basis of the shape of the discharge patterns to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.1.162
更新日期:1976-01-01 00:00:00
abstract::To clarify the role of cholinergic inputs to the intermediate layer of the superior colliculus (SC), we examined the effect of microinjection of nicotine into the SC on visually guided saccades in macaque monkeys. After injection of 0.4-2 microl of 1-100 mM nicotine into the SC, frequency of extremely short latency sa...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.3.1642
更新日期:1999-09-01 00:00:00
abstract::Spinothalamic (ST) neurons in the C8-T5 segments of the spinal cord were examined for responses to electrical stimulation of the left thoracic vagus nerve (LTV). Seventy-one ST neurons were studied in 39 anesthetized monkeys (Macaca fascicularis). Each neuron could be excited by manipulation of its somatic field and b...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.4.926
更新日期:1983-10-01 00:00:00
abstract::We compared electroretinographic (ERG) responses to uniform-field and a variety of pattern stimuli using both transient and steady-state analyses. Evidence is provided that for all of these stimuli, the peak at high temporal frequencies in the steady-state response corresponds to the fast wave of the transient respons...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.51.5.952
更新日期:1984-05-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.4.2219
更新日期:1997-04-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.5.1069
更新日期:1976-09-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00053.2008
更新日期:2008-05-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.63.1.161
更新日期:1990-01-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.6.3201
更新日期:2000-06-01 00:00:00
abstract::1. The aims of this study were 1) to determine whether the impulse activity in rabbit aortic baroreceptors (BRs) was influenced by changes in nonpulsatile flow through the aortic lumen and 2) to examine the BR and aortic arch responses to changes in temperature. 2. An in vitro aortic arch-aortic nerve preparation was ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.70.6.2596
更新日期:1993-12-01 00:00:00
abstract::Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular dri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00437.2018
更新日期:2019-02-01 00:00:00
abstract::Excitatory postsynaptic potentials (EPSPs) were evoked in large populations of motoneurons by impulses in single Ia- and group II fibers and recorded from L7 and S1 ventral roots by means of a sucrose-gap technique and spike-triggered averaging, as previously described (33, 34). Factors known to influence conduction a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.5.1045
更新日期:1983-11-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00966.2007
更新日期:2008-03-01 00:00:00
abstract::1. It has been suggested that passive diffusion is the principal mechanism of the clearance of locally elevated extracellular potassium, K+o, in the cerebral cortex. This concept was based on the assumption that elevated K+ could be modeled as a point source. In the present study, the functional role of passive diffus...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1977.40.5.1015
更新日期:1977-09-01 00:00:00
abstract::Based on the findings of the preceding paper, it is known that auditory and visual signals have been translated into common coordinates at the level of the superior colliculus (SC) and share a motor circuit involved in the generation of saccadic eye movements. It is not known, however, whether the translation of senso...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.1.35
更新日期:1987-01-01 00:00:00