Abstract:
BACKGROUND AND PURPOSE:Reduction of cerebral blood flow results in several acute metabolic disturbances, including a reduction in Na,K-ATPase activity. The relation between this reduction and the onset of edema is unknown, as is the effect of restoration of blood flow. Therefore, we investigated the role of decreased Na,K-ATPase activity in the pathogenesis and time course of ischemic brain edema and reperfusion. METHODS:The middle cerebral arteries of rats were occluded by cannulation with a nylon suture for 30, 60, 120, or 240 minutes. The animals were then decapitated (permanent occlusion) or the suture was withdrawn to allow 24 hours of reperfusion before decapitation (temporary occlusion). Na,K-ATPase activity and Na+, K+ and water contents were measured at various intervals. RESULTS:In the ischemic hemisphere, Na,K-ATPase activity was significantly decreased at 30, 60, 120, and 240 minutes of permanent occlusion (p less than 0.05). There was also a significant decrease in rats subjected to 60 or 120 minutes of temporary occlusion followed by 24 hours of reperfusion. Water content increased after 60, 120, or 240 minutes of permanent occlusion (p less than 0.01); after 24 hours of reperfusion, water content remained elevated (p less than 0.01). The Na+ content increased after both permanent and temporary occlusion, and the K+ content decreased only after permanent occlusion. Increases in water content correlated with decreases in Na,K-ATPase activity after temporary occlusion and with the Na+:K+ ratio after permanent occlusion. CONCLUSION:Reduction in Na,K-ATPase activity resulting in disruption of cellular ionic homeostasis may account for early development of cytotoxic brain edema after permanent occlusion of the middle cerebral artery. Such edema is also present 24 hours after 60 and 120 but not 30 minutes of temporary occlusion.
journal_name
Strokejournal_title
Strokeauthors
Yang GY,Chen SF,Kinouchi H,Chan PH,Weinstein PRdoi
10.1161/01.str.23.9.1331subject
Has Abstractpub_date
1992-09-01 00:00:00pages
1331-6issue
9eissn
0039-2499issn
1524-4628journal_volume
23pub_type
杂志文章相关文献
STROKE文献大全abstract::Changes of regional cerebral blood flow from rest to mental activation by a visually presented spatial reasoning test were measured during normo- and hypercapnia in 10 healthy subjects. Hypercapnia, elicited by inhalation of 6% CO2, resulted in similar flow increases in all 32 cortical regions measured. Increases of f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.4.342
更新日期:1980-07-01 00:00:00
abstract::Background and Purpose- Hyperacute assessment and management of patients with stroke, termed code stroke, is a time-sensitive and high-stakes clinical scenario. In the context of the current coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus, the ability to deliver timely and efficacious care ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029838
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The EuroQol and Medical Outcome Survey 36-item short-form health survey (SF-36) questionnaires have both been validated for the assessment of health-related quality of life after stroke. However, the relationship between these instruments has not been studied after stroke. We therefore sought to ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.30.10.2146
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Systemic inflammatory response syndrome (SIRS) is a generalized inflammatory state. The primary goal of the study was to determine whether differences exist in outcomes in SIRS and non-SIRS intravenous tissue-type plasminogen activator-treated patients. METHODS:Consecutive patients were retrospe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001371
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Downregulation of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is thought to be a novel neuroprotective strategy in ischemic stroke, but the underlying mechanisms remain unclear. In this study, we aimed to validate the use of PTEN regulation of gamma-amino...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.579011
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:An increase in intima-media thickness (IMT) in the common carotid artery (CCA) is commonly used as a marker of atherosclerosis. The purpose of this study was to investigate the relationship between IMT in the CCA and atherosclerosis in the carotid bifurcation. METHODS:182 consecutive patients (m...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.7.1378
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess brain perfusion with an ultrasound contrast-specific imaging mode and to prove if the results are comparable between 2 centers using a standardized study protocol. METHODS:A total of 32 individuals without known cerebrovascular disease were included in the...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000179038.63109.b0
更新日期:2005-10-01 00:00:00
abstract::We studied a possible relation between stroke and an enhanced susceptibility to rupture of the arterial internal elastic lamina by comparing stroke-prone spontaneously hypertensive rats with spontaneously hypertensive rats, which have a very low incidence of stroke. We quantified interruptions in the internal elastic ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.4.510
更新日期:1991-04-01 00:00:00
abstract::The protective properties of PY 108-068 against ischemic disturbances in the brain were investigated in vitro and in vivo. The calcium antagonistic effects were demonstrated on isolated, calcium-loaded arterial rings of feline cerebral arteries. Determination of brain tissue oxygenation with pO2 microelectrodes showed...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.4.679
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex ...
journal_title:Stroke
pub_type: 杂志文章,实务指引
doi:10.1161/01.str.0000441965.15164.d6
更新日期:2014-04-01 00:00:00
abstract::Corticomotor evoked potentials have recently been used in experimental animals and patients as a measure of neurologic function after stroke. However, little is known about the fundamental electrophysiologic properties contributing to the formation of these potentials. To define some of these properties, corticomotor ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.6.1141
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated cardiac troponin is a marker of cardiac disease and has been recently shown to be associated with embolic stroke risk. We hypothesize that early elevated troponin levels in the acute stroke setting are more prevalent in patients with embolic stroke subtypes (cardioembolic and embolic str...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019395
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recombinant tissue plasminogen activator (rtPA; Actilyse) is not as widely used in clinical practice as it could be. Have new data since 1995 strengthened the evidence sufficiently to justify more widespread use of rtPA? METHODS:We performed a sequential year-to-year cumulative meta-analysis of ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/01.STR.0000072513.72262.7E
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We performed the present study to determine whether the site of occlusion in the vertebrobasilar circulation could be identified by the measurement of blood flow velocity in the bilateral vertebral arteries. METHODS:Using color-coded duplex carotid ultrasonography, we measured the time-averaged ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.5.1006
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite rapid advancements in intracranial aneurysm management, there is no evidence as of yet that this has translated into improvement in overall prognosis. METHODS:We compared 2 periods of aneurysm management, 1998 to 2003 (n=1023 aneurysms) and 2007 to 2013 (n=1499 aneurysms), at a single, h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.011959
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of decompressive hemicraniectomy (DC) in malignant cerebral infarction (MCI) has clearly been established, but little is known about the course of intracranial pressure (ICP) in patients undergoing this surgical measure. In this study, we investigated the role of invasive ICP monitoring ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.032390
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aim to evaluate if good collateral flow (CF) modifies endovascular therapy (EVT) efficacy on large-vessel stroke. To do that, we used final degree of reperfusion and number of device-passes performed, factors previously associated with better functional outcome, as main outcome measures. METH...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031338
更新日期:2021-01-01 00:00:00
abstract::Background and Purpose- Prestroke dependence is an exclusion criterion in most trials of endovascular treatment (EVT) for acute ischemic stroke. Little is known about outcomes after EVT in these patients. We compared outcome and safety of EVT between prestroke-dependent and prestroke-independent patients. Methods- We ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.118.022352
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pres...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.7.988
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes. METHODS:In a prospective multicenter cohort study of imaging selection for endovascular thrombectomy (SELECT [Optimizing Patient's Selection for Endovascular Treatmen...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.030912
更新日期:2021-01-01 00:00:00
abstract::Of 171 patients evaluated prospectively and consecutively for cerebral ischemia, 26 (15%) developed symptoms while hospitalized. Cerebral ischemia complicated operative procedures in 12 patients, unsuccessful cardioversion in one and coronary angiography in another. Twelve patients had apparent cerebral embolism and 1...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.3.430
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients' age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.020511
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Within different brain regions, we determine the comparative value of multiphase computed tomographic angiography (mCTA) and computed tomographic perfusion (CTP) in predicting follow-up infarction. METHODS:Patients with M1-middle cerebral artery occlusions were prospectively included in this mul...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.116.015969
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A significant number of patients with aneurysmal subarachnoid hemorrhage are active smokers and at risk for acute nicotine withdrawal. There is conflicting literature regarding the vascular effects of nicotine and theoretical concern that it may worsen vasospasm. The literature on the safety of n...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.620955
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. However, the effects of dipyridamole on cerebral circulation is not pronounced. This study invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.8.1616
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The modified Rankin Scale (mRS) is widely used to assess global outcome after stroke. The aim of the study was to examine rater variability in assessing functional outcomes using the conventional mRS, and to investigate whether use of a structured interview (mRS-SI) reduced this variability. MET...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000157596.13234.95
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Mechanical thrombectomy (MT) is the recommended treatment for acute ischemic stroke caused by anterior circulation large vessel occlusion. However, despite a high rate of reperfusion, the clinical response to successful MT remains highly variable in the early time window where optimal imaging sel...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031929
更新日期:2021-01-01 00:00:00
abstract::The effect of cigarette smoking on extracranial carotid atherosclerosis was studies by obtaining cigarette smoking histories and information on other potential risk factors from consecutive patients undergoing carotid arteriography. At least on extracranial carotid artery was visualized in 752 patients in whom the ext...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.5.707
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:Diffusion-weighted MRI (DWI) and perfusion-weighted MRI (PWI) are new techniques that can be used for the evaluation of acute ischemic stroke. However, their potential role in the management of patients treated with recombinant tissue plasminogen activator (rtPA) has yet to be determined. CASE DESCRIPTION:T...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.3.678
更新日期:1999-03-01 00:00:00
abstract::The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral capillaries, i.e. the blood-brain barrier, was studied in normotensive Wistar and spontaneously hypertensive Wistar rats with experimental subarachnoid hemorrhage. The blood-brain barrier permeability to albumin was assesse...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.3.498
更新日期:1986-05-01 00:00:00