Systemic inflammatory response syndrome in tissue-type plasminogen activator-treated patients is associated with worse short-term functional outcome.

Abstract:

BACKGROUND AND PURPOSE:Systemic inflammatory response syndrome (SIRS) is a generalized inflammatory state. The primary goal of the study was to determine whether differences exist in outcomes in SIRS and non-SIRS intravenous tissue-type plasminogen activator-treated patients. METHODS:Consecutive patients were retrospectively reviewed for the evidence of SIRS during their admission. SIRS was defined as the presence of ≥2 of the following: body temperature<36°C or >38°C, heart rate>90, respiratory rate>20, and white blood cells<4000/mm or >12 000 mm, or >10% bands. Patients diagnosed with infection (via positive culture) were excluded. RESULTS:Of the 241 patients, 44 had evidence of SIRS (18%). Adjusting for pre-tissue-type plasminogen activator National Institutes of Health Stroke Scale, age, and race, SIRS remained a predictor of poor functional outcome at discharge (odds ratio [OR], 2.58; 95% confidence interval [CI], 1.16-5.73; P=0.0197). CONCLUSIONS:In our sample of tissue-type plasminogen activator-treated (tPA) patients, ~1 in 5 patients developed SIRS. Furthermore, we found the presence of SIRS to be associated with poor short-term functional outcomes and prolonged length of stay.

journal_name

Stroke

journal_title

Stroke

authors

Boehme AK,Kapoor N,Albright KC,Lyerly MJ,Rawal PV,Bavarsad Shahripour R,Alvi M,Houston JT,Sisson A,Beasley TM,Alexandrov AW,Alexandrov AV,Miller DW

doi

10.1161/STROKEAHA.113.001371

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

2321-3

issue

8

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.113.001371

journal_volume

44

pub_type

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