[The pathogenesis of chronic Chagas' myocarditis: the role of autoimmune and microvascular factors].

Abstract:

:The pathogenesis of chronic chagasic myocarditis remains incompletely understood. Several hypotheses have been proposed: (1) direct tissue destruction by Trypanosoma cruzi; (2) neurogenic theory; (3) anti-heart immune reactions; and (4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocytes hypertrophy. These processes may be initiated and perpetuated by autoimmune factors and alterations in the myocardial microcirculation. This could imply future therapeutic strategies in the management of chronic chagasic patients to optimize the medical treatment and hopefully improve the prognosis.

authors

Rossi MA,Mengel JO

doi

10.1590/s0036-46651992000600015

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

593-9

issue

6

eissn

0036-4665

issn

1678-9946

journal_volume

34

pub_type

杂志文章,评审
  • MOLLUSCICIDAL AND LARVICIDAL ACTIVITIES OF Atriplex inflata AERIAL PARTS AGAINST THE MOLLUSK Galba truncatula, INTERMEDIATE HOST OF Fasciola hepatica.

    abstract::Fasciolosis is a widespread parasitosis of farm live-stock in many developing countries. For this reason, it is necessary to search for new substances against parasitic diseases caused by flukes. Indeed, a wide variety of terrestrial plants have been subjected to chemical and pharmacological screening in order to disc...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S0036-46652015000600003

    authors: Hamed N,Njeh F,Damak M,Ayadi A,Mezghani-Jarraya R,Hammami H

    更新日期:2015-12-01 00:00:00

  • Tuberculous brain abscess in a patient with AIDS: case report and literature review.

    abstract::Tuberculous brain abscesses in AIDS patients are considered rare with only eight cases reported in the literature. We describe the case of a 34-year-old woman with AIDS and previous toxoplasmic encephalitis who was admitted due to headache and seizures. A brain computed tomography scan disclosed a frontal hypodense le...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章,评审

    doi:10.1590/s0036-46652003000200013

    authors: Vidal JE,Cimerman S,da Silva PR,Sztajnbok J,Coelho JF,Lins DL

    更新日期:2003-03-01 00:00:00

  • Anopheles (Kerteszia) cruzii (Diptera: Culicidae) in peridomiciliary area during asymptomatic malaria transmission in the Atlantic Forest: molecular identification of blood-meal sources indicates humans as primary intermediate hosts.

    abstract::Anopheles (Kerteszia) cruzii has been implicated as the primary vector of human and simian malarias out of the Brazilian Amazon and specifically in the Atlantic Forest regions. The presence of asymptomatic human cases, parasite-positive wild monkeys and the similarity between the parasites infecting them support the d...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652014000500006

    authors: Kirchgatter K,Tubaki RM,Malafronte Rdos S,Alves IC,Lima GF,Guimarães Lde O,Zampaulo Rde A,Wunderlich G

    更新日期:2014-09-01 00:00:00

  • Production of monoclonal antibodies anti-Taenia crassiceps cysticerci with cross-reactivity with Taenia solium antigens.

    abstract::We describe the production of the potential monoclonal antibodies (MoAbs) using BALB/c mice immunized with vesicular fluid (VF)-Tcra (T. crassiceps) antigen. Immune sera presented anti-VF-Tcra (<20kD) IgG and IgM antibodies with cross-reactivity with T. solium (Tso) antigen (8-12, 14, and 18 kD). After cell fusion, we...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652000000300013

    authors: Espíndola NM,De Gaspari EN,Nakamura PM,Vaz AJ

    更新日期:2000-05-01 00:00:00

  • Chagas disease in the Brazilian Amazon: IV. a new cross-sectional study.

    abstract::A new conglomerate family sample of 194 dwellings with 996 resident persons were studied in the town of Barcelos, State of Amazonas, in order to re-evaluate the risk of Chagas disease. During the survey the persons were interviewed and in this occasion we showed to them a collection of Panstrongylus, Rhodnius and Tria...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652002000300009

    authors: Coura JR,Junqueira AC,Boia MN,Fernandes O,Bonfante C,Campos JE,Santos L,Devera R

    更新日期:2002-05-01 00:00:00

  • Intestinal parasitic infections among expatriate workers in various occupations in Sharjah, United Arab Emirates.

    abstract::Intestinal parasitic infections are prevalent throughout many countries. This study aimed to determine the prevalence of intestinal parasite carriers among 21,347 expatriate workers, including food handlers and housemaids attending the public health center laboratory in Sharjah, UAE. Stool sample collection was perfor...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946201759082

    authors: Dafalla AIA,Almuhairi SASO,AlHosani MHJ,Mohamed MY,Alkous MIA,AlAzzawi MA,Abakar AD,Nour BYM,Hasan H,AbuOdeh RO,ElBakri A

    更新日期:2017-12-21 00:00:00

  • Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs.

    abstract::Canine visceral leishmaniasis (CVL) is recognizable by characteristic signs of disease and is highly lethal. The infection, however, may be quite inapparent in some seropositive dogs, and this has raised the polemic question as to whether or not such animals can be a source of infection for Lutzomyia longipalpis, the ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652010000500007

    authors: Lima LV,Carneiro LA,Campos MB,Chagas EJ,Laurenti MD,Corbett CE,Lainson R,Silveira FT

    更新日期:2010-09-01 00:00:00

  • Production of Schistosoma mansoni cercariae by Biomphalaria glabrata from a focus in Belo Horizonte, Minas Gerais.

    abstract::The snail density, levels of infection and the monthly production of Schistosoma mansoni cercariae by Biomphalaria glabrata were determined in a focus of Barreiro de Baixo (Belo Horizonte, MG, Brazil). During a period of 38 months (1984 to 1987) 5,366 snails were collected of which 324 (6.03%) were infected with S. ma...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651994000600002

    authors: de Souza CP,Araújo N,Jannotti-Passos LK,Guimarães CT

    更新日期:1994-11-01 00:00:00

  • Factors associated with TB in an indigenous population in Brazil: the effect of a cash transfer program.

    abstract::The Mato Grosso do Sul State (MS) has the second-largest indigenous population and the highest incidence rates of TB among indigenous people in Brazil. However, little is known about the risk factors associated with active TB in indigenous people in the region, especially regarding socioeconomic factors. The aim of th...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946201860063

    authors: Malacarne J,Kolte IV,Freitas LP,Orellana JDY,Souza MLP,Souza-Santos R,Basta PC

    更新日期:2018-10-25 00:00:00

  • Immunostimulation as adjuvant for the chemotherapy of experimental schistosomiasis.

    abstract::Immunosuppressed animals respond poorly to schistosomal chemotherapy and a proper response can be restored by the administration of immune serum. Present study attempts to search whether immunological stimulation would increase drug effectiveness. Swiss mice infected with 50 S. mansoni cercariae were later treated wit...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651997000100003

    authors: Silva LM,Andrade ZA

    更新日期:1997-01-01 00:00:00

  • The spectrum of computerized tomography (CT) findings in central nervous system (CNS) infection due to Cryptococcus neoformans var. gattii in immunocompetent children.

    abstract::Cranial CT scans of eleven immunocompetent children with central nervous system (CNS) infection due to Cryptococcus neoformans var. gattii were retrospectively reviewed. These children had an average age of 8.8 years and positive culture for C. n. var. gattii in cerebrospinal fluid. The most common signs and symptoms ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652002000500010

    authors: Correa Mdo P,Severo LC,Oliveira Fde M,Irion K,Londero AT

    更新日期:2002-09-01 00:00:00

  • Effect of Cysticercus cellulosae fractions on the respiratory burst of pig neutrophils.

    abstract::Neutrophils, eosinophils and macrophages are cells that interact with invading parasites and naive hosts have been shown to have anti-parasitic activity. The initial reaction of these leukocytes is the generation of reactive oxygen species (ROS) to play in parasite expulsion. The present work was carried out to study ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652005000200006

    authors: Pugine SM,Faria MF,Maia AA,Valle CR,Boschini C,Poleti MD,Silva MR,De Melo MP

    更新日期:2005-03-01 00:00:00

  • Clinical and endoscopic findings in the mucosae of the upper respiratory and digestive tracts in post-treatment follow-up of paracoccidioidomycosis patients.

    abstract::Systematic examination of the upper respiratory and digestive tracts (URDT) was performed in a group of 80 paracoccidioidomycosis (PCM) patients submitted to post-treatment follow-up ranging from 8 months to 17 years. Mucosae of the URDT had been involved prior to specific treatment in 74 patients, distributed as foll...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651995000500005

    authors: do Valle AC,Aprigliano Filho F,Moreira JS,Wanke B

    更新日期:1995-09-01 00:00:00

  • [A case of human brain infection caused by racemose cysticercus of parenchymal localization in Valdivia, Chile].

    abstract::A clinical case of cerebral infection by parenchymal racemose cysticercus, diagnosed by means of morphological characteristics in a patient of Valdivia city is described. The rare frequency of parenchymal location of racemose cysticercus as well as its differential diagnosis with other larval stages of cestodes that d...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651991000300011

    authors: Ortega E,Torres P

    更新日期:1991-05-01 00:00:00

  • Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparum malaria on oral therapy.

    abstract::We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasm...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 临床试验,杂志文章

    doi:10.1590/s0036-46652009000200009

    authors: Vieira JL,Gomes AL,Borges LM,Guimarães ER

    更新日期:2009-03-01 00:00:00

  • Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha.

    abstract::The response to interferon treatment in chronic hepatitis NANB/C has usually been classified as complete, partial or absent, according to the behavior of serum alanine aminotransferase (ALT). However, a more detailed observation of the enzymatic activity has shown that the patterns may be more complex. The aim of this...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651995000300010

    authors: da Silva LC,Ono SK,Fonseca LE,Carrilho FJ,Mendes LC,França AV,Madruga CL,Laudanna AA

    更新日期:1995-05-01 00:00:00

  • Validity of selected clinical signs and symptoms in diagnosis of Schistosoma mansoni infection.

    abstract::Sensitivity, specificity and positive predictive values of selected clinical signs and symptoms in the diagnosis of Schistosoma mansoni infection were evaluated in 403 individuals (69% of inhabitants over 1 year of age) in an endemic area in Brazil (Divino). Highest sensitivity (13%) was found for blood in stools. Spe...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651991000100003

    authors: de Lima e Costa MF,Rocha RS,Colley D,Gazzinelli G,Katz N

    更新日期:1991-01-01 00:00:00

  • Listeria monocytogenes peritonitis in cirrhotic patients: first description in Brazil.

    abstract::Two cases of spontaneous bacterial peritonitis (SBP) caused by Listeria monocytogenes in cirrhotic patients are reported. In one of the cases, the microorganism was isolated from pleural effusion and ascites. SBP is a serious and common complication of patients with ascites caused by hepatic cirrhosis and the culture ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652006000500010

    authors: Toyoshima MT,Apanavicius A,de Matos Soeiro A,de Almeida GM,Arai MH

    更新日期:2006-09-01 00:00:00

  • In vitro synergism of simvastatin and fluconazole against Candida species.

    abstract::Systemic fungal infections are responsible for high mortality rates. Several species of fungi may be involved, but Candida spp. is the most prevalent. Simvastatin is used to lower cholesterol and also exhibits antifungal action. The aim of this study was to evaluate the synergistic action of simvastatin with fluconazo...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652012000400003

    authors: Menezes EA,Vasconcelos Júnior AA,Silva CL,Plutarco FX,Cunha Mda C,Cunha FA

    更新日期:2012-08-01 00:00:00

  • Potential of biologically active plant oils to control mosquito larvae (Culex pipiens, Diptera: Culicidae) from an Egyptian locality.

    abstract::The insecticidal effect of six commercially available plant oils was tested against 4th larval instars of Culex pipiens. Larvae were originally collected from Meit El-Attar, Qalyubia Governorate, Egypt, and then reared in the laboratory until F1 generation. The LC50 values were 32.42, 47.17, 71.37, 83.36, 86.06, and 1...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652008000200008

    authors: Khater HF,Shalaby AA

    更新日期:2008-03-01 00:00:00

  • Epidemiological profile of snakebite accidents in a metropolitan area of northeast Brazil.

    abstract::The aim of this study was to describe the epidemiological profile of snakebite accidents reported by the toxicological assistance center in Fortaleza, Ceará, Brazil. Database information on snakebite accidents was analyzed regarding the period from January 2003 to December 2011. A total of 1063 cases were found. The a...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S0036-46652013000500009

    authors: Albuquerque PL,Silva Junior GB,Jacinto CN,Lima CB,Lima JB,Veras Mdo S,Daher EF

    更新日期:2013-09-01 00:00:00

  • Immune response in mice immunized with acidic antigenic fractions from Trypanosoma cruzi cytosol.

    abstract::The humoral and cellular immune responses as well as the resistance to infection with bloodstream forms of T. cruzi were studied in mice immunized with acidic antigenic fractions from parasite cytosol, F III and F IV, plus Bordetella pertussis as adjuvant. The immunization with F III induced positive ITH and DTH respo...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651992000500003

    authors: Gea S,Gruppi A,Cerban F,Pistoresi Palencia MC,Vottero-Cima E

    更新日期:1992-09-01 00:00:00

  • [Staphylococcal coagglutination reaction in the identification of mycoplasma].

    abstract::Staphylococcal Coagglutination was used as method for a rapid identification of mycoplasmas that could be performed by non specialized laboratories. Suspensions of Staphylococcus aureus (Cowan I) sensitized with rabbit antibodies against NCTC mycoplasma strains have identified these microorganisms and the strains isol...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:

    authors: Timenetsky J,Curcio M

    更新日期:1993-11-01 00:00:00

  • Refractory pemphigus vulgaris associated with herpes infection: case report and review.

    abstract:BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering of the skin and mucosa, which develops due to the interaction between predisposing genetic and environmental factors. Infections caused by members of the Herpesviridae family have been suggested as a possible triggering factor for P...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章,评审

    doi:10.1590/s0036-46652011000200010

    authors: Brandão ML,Fernandes NC,Batista DP,Santos N

    更新日期:2011-03-01 00:00:00

  • [Neurocysticercosis with initial clinical picture of acute meningitis].

    abstract::Twenty seven cases of neurocysticercosis, with clinical picture of acute meningitis, are described. Twenty (74.1%) patients are male; the age was 4 to 42 years (23.6 +/- 11.7 years). The etiologic diagnosis was defined by the complement fixation test (Weinberg) and/or enzyme-linked immunosorbent assay (ELISA) for cyst...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:

    authors: Bonametti AM,Baldy JL,Bortoliero AL,de Maio CM,Passos Jdo N,Takata PK,de Pauli DS,Guimarães JC,Anzai ET,Elisbão Mdo C

    更新日期:1994-01-01 00:00:00

  • Evolution of IgG antibody response against Toxoplasma gondii tissue cyst in acute and chronic human infections.

    abstract::The recognition profile of the tissue cysts antigens by IgG antibodies was studied during acute and chronic human toxoplasmic infection. Thus the IgG response against Toxoplasma gondii was investigated by immunoblotting in two patients accidentally infected with the RH strain as well as in group of naturally infected ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651998000200003

    authors: Villavedra M,Carol H,Nieto A

    更新日期:1998-03-01 00:00:00

  • Failure of nitric oxide production by macrophages and decrease in CD4+ T cells in oral paracoccidioidomycosis: possible mechanisms that permit local fungal multiplication.

    abstract::Paracoccidioidomycosis is a chronic granulomatous disease that induces a specific inflammatory and immune response. The participation of nitric oxide (NO), a product of the inducible nitric oxide synthase enzyme (iNOS), as an important fungicidal molecule against Paracoccidioides brasiliensis has been demonstrated. In...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652005000500006

    authors: Batista AC,Soares CT,Lara VS

    更新日期:2005-09-01 00:00:00

  • Acute postsurgical suppurative parotitis: current prevalence at Hospital das Clínicas, São Paulo University Medical School.

    abstract::Postsurgical acute suppurative parotitis is a bacterial gland infection that occurs from a few days up to some weeks after abdominal surgical procedures. In this study, the authors analyze the prevalence of this complication in Hospital das Clínicas/São Paulo University Medical School by prospectively reviewing the ch...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652008000500010

    authors: Belczak SQ,Cleva RD,Utiyama EM,Cecconello I,Rasslan S,Parreira JG

    更新日期:2008-09-01 00:00:00

  • Membrane fractions from Strongyloides venezuelensis in the immunodiagnosis of human strongyloidiasis.

    abstract::Strongyloides venezuelensis is a parasitic nematode of rodents frequently used to obtain heterologous antigens for the immunological diagnosis of human strongyloidiasis. The aim of this study was to evaluate membrane fractions from S. venezuelensis for human strongyloidiasis immunodiagnosis. Soluble and membrane fract...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S0036-46652015000100011

    authors: Corral MA,Paula FM,Gottardi M,Meisel DM,Chieffi PP,Gryschek RC

    更新日期:2015-01-01 00:00:00

  • Human ocular sparganosis in southern Brazil.

    abstract::We report the first case of human ocular sparganosis in the state of Santa Catarina, southern Brazil. A young female patient presented with three periocular moveable inflammatory masses in her right eye, during two years. By surgical excisional biopsy, a helminth larval stage was removed and identified as sparganum. C...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652011000100009

    authors: Mentz MB,Procianoy F,Maestri MK,Rott MB

    更新日期:2011-01-01 00:00:00