In vitro synergism of simvastatin and fluconazole against Candida species.

Abstract:

:Systemic fungal infections are responsible for high mortality rates. Several species of fungi may be involved, but Candida spp. is the most prevalent. Simvastatin is used to lower cholesterol and also exhibits antifungal action. The aim of this study was to evaluate the synergistic action of simvastatin with fluconazole against strains of Candida spp. Susceptibility testing was performed according to protocol M27-A3, by broth microdilution method and the synergistic effect of simvastatin and fluconazole was calculated based on FICI (Fractional Inhibitory Concentration Index). Eleven strains were evaluated, and simvastatin showed a synergistic effect with fluconazole against 10 (91%) of the Candida spp. strains tested. Simvastatin may be a valuable drug in the treatment of systemic infections caused by Candida spp.

authors

Menezes EA,Vasconcelos Júnior AA,Silva CL,Plutarco FX,Cunha Mda C,Cunha FA

doi

10.1590/s0036-46652012000400003

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

197-9

issue

4

eissn

0036-4665

issn

1678-9946

pii

S0036-46652012000400003

journal_volume

54

pub_type

杂志文章
  • Clinical and microbiological characteristics of patients colonized or infected by Stenotrophomonas maltophilia : is resistance to sulfamethoxazole/trimethoprim a problem?

    abstract::Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen in the last decade. Increased resistance to sulfamethoxazole/trimethoprim (SMX/TMP) has been reported in S. maltophilia strains in the past few years, leading to few therapeutic options. We conducted a prospective multicenter study at two ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946202062096

    authors: Mendes ET,Paez JIG,Ferraz JR,Marchi AP,Silva ILAFE,Batista MV,Lima ALM,Rossi F,Levin AS,Costa SF

    更新日期:2020-12-07 00:00:00

  • [Immediate hypersensitivity reactions after intravenous use of antivenin sera: prognostic value of intradermal sensitivity tests].

    abstract::The frequency and class of immediate-type hypersensitivity manifestations were studied in 494 snakebitten and scorpion stung patients who were treated with intravenous injections of antivenom sera. These patients were admitted to HC-FMRPUSP from 1983 to 1988. The effectiveness of a hypersensitivity skin test was also ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:

    authors: Cupo P,Azevedo-Marques MM,de Menezes JB,Hering SE

    更新日期:1991-03-01 00:00:00

  • Geoprocessing and spatial analysis for identifying leptospirosis risk areas: a systematic review.

    abstract::Leptospirosis is a reemerging zoonosis caused by bacteria of the genus Leptospira sp. with global importance in the medical and veterinary fields, being responsible for about 59 thousand deaths each year in the world. The use of Geographic Information Systems (GIS) in the health sector is propitious and has been adopt...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946202062035

    authors: Souza IPO,Uberti MS,Tassinari WS

    更新日期:2020-06-05 00:00:00

  • Comparative study on the localization of adult Schistosoma mansoni worms in albino mice anesthetized with pentobarbital sodium, ether or chloroform.

    abstract::The effect of anesthetic drugs on the localization of adult worms in albino mice was compared. The animals with 56 days of infection were anesthetized with pentobarbital sodium, ether or chloroform. Perfusion was carried out immediately after, recovering the worms and classifying them in relation to their localization...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651993000400003

    authors: Machado e Silva JR,de Lima MA,Rodrigues e Silva R,Maldonado Júnior A,Presgrave OA,Rey L

    更新日期:1993-07-01 00:00:00

  • Contamination of public parks and squares from Guarulhos (São Paulo State, Brazil ) by Toxocara spp. and Ancylostoma spp.

    abstract::The contaminated soil with mammal feces is an important factor of risk to infection with zoonotic diseases. Amongst these zoonoses are visceral larva migrans and cutaneous larva migrans caused by Toxocara spp. and Ancylostoma spp., respectively. The aim of this study was to assess the environmental contamination by To...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652012000500006

    authors: Marques JP,Guimarães Cde R,Boas AV,Carnaúba PU,Moraes Jd

    更新日期:2012-09-01 00:00:00

  • Prevalence of hepatitis C virus infection in quilombo remnant communities in Central Brazil.

    abstract::In order to determine the prevalence of hepatitis C virus (HCV) infection in quilombo remnant communities in Central Brazil, 1,007 subjects were interviewed in all 12 communities existing in Mato Grosso do Sul State, Central Brazil. Blood samples were collected and sera were tested for anti-HCV by enzyme-linked immuno...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652008000600010

    authors: Reis NR,Motta-Castro AR,Silva AM,Teles SA,Yoshida CF,Martins RM

    更新日期:2008-11-01 00:00:00

  • [Clinico-mycological study of onychomycosis in elderly patients].

    abstract::Physical examination of nails was carried out in 210 elderly patients and nail scrapings were obtained from onychomycosis suggested lesions in order to determine their causative agents, incidence and clinical characteristics. Diagnostic was confirmed by the isolation of the agents from 74 patients, mainly from toe-nai...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651993000300001

    authors: Rodríguez-Soto ME,Fernández-Andreu CM,Moya Duque S,Rodríguez Díaz RM,Martínez-Machín G

    更新日期:1993-05-01 00:00:00

  • Molecular characterization of Cryptosporidium spp. from HIV infected patients from an urban area of Brazil.

    abstract::Cryptosporidium spp. are important cause of enteric disease in humans, but may also infect animals. This study describes the relative frequency of several Cryptosporidium species found in human specimens from HIV infected patients in the São Paulo municipality obtained from January to July 2007. Sequence analysis of t...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652009000600006

    authors: Lucca Pd,De Gaspari EN,Bozzoli LM,Funada MR,Silva SO,Iuliano W,Soares RM

    更新日期:2009-10-01 00:00:00

  • Immunoprecipitation techniques and Elisa in the detection of anti-Fonsecaea pedrosoi antibodies in chromoblastomycosis.

    abstract::Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by several dematiaceous fungi. The most commonly etiological agent found in Brazil is Fonsecaea pedrosoi, which appears as thick walled, brownish colored cells with transverse and longitudinal division in the lesions, called "muriform cells". This di...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652003000600003

    authors: Vidal MS,de Castro LG,Cavalecate SC,Lacaz Cda S

    更新日期:2003-11-01 00:00:00

  • MOLLUSCICIDAL AND LARVICIDAL ACTIVITIES OF Atriplex inflata AERIAL PARTS AGAINST THE MOLLUSK Galba truncatula, INTERMEDIATE HOST OF Fasciola hepatica.

    abstract::Fasciolosis is a widespread parasitosis of farm live-stock in many developing countries. For this reason, it is necessary to search for new substances against parasitic diseases caused by flukes. Indeed, a wide variety of terrestrial plants have been subjected to chemical and pharmacological screening in order to disc...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S0036-46652015000600003

    authors: Hamed N,Njeh F,Damak M,Ayadi A,Mezghani-Jarraya R,Hammami H

    更新日期:2015-12-01 00:00:00

  • Seroprevalence for hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná , Brazil.

    abstract::A cross-sectional study was carried out among 996 volunteer blood donors enrolled from May 1999 to December 1999 to determine the seroprevalence of hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, Brazil, and to evaluate whether the rate of seropre...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652006000200006

    authors: Bortoliero AL,Bonametti AM,Morimoto HK,Matsuo T,Reiche EM

    更新日期:2006-03-01 00:00:00

  • Experimental infection of Swiss and AKR/J mice with Centrocestus formosanus (Trematoda: Heterophyidae).

    abstract::In order to better understand the biology of Centrocestus formosanus in a definitive host model, mice of Swiss and AKR/J strains were experimentally infected with 100 metacercariae of the parasite. Fourteen days post-infection, the rodents were killed and adult trematodes were recovered from the small intestine. The p...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652013000200013

    authors: Mati VL,Pinto HA,Melo AL

    更新日期:2013-03-01 00:00:00

  • Production of monoclonal antibodies anti-Taenia crassiceps cysticerci with cross-reactivity with Taenia solium antigens.

    abstract::We describe the production of the potential monoclonal antibodies (MoAbs) using BALB/c mice immunized with vesicular fluid (VF)-Tcra (T. crassiceps) antigen. Immune sera presented anti-VF-Tcra (<20kD) IgG and IgM antibodies with cross-reactivity with T. solium (Tso) antigen (8-12, 14, and 18 kD). After cell fusion, we...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652000000300013

    authors: Espíndola NM,De Gaspari EN,Nakamura PM,Vaz AJ

    更新日期:2000-05-01 00:00:00

  • Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil.

    abstract::This study evaluated the whole blood immunochromatographic card test (ICT card test) in a survey performed in Northeastern Brazil. 625 people were examined by the thick blood film (TBF) and ICT card test. Residents of a non-endemic area were also tested by the whole blood card test and Og4C3. The sensitivity of the IC...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652003000300002

    authors: Braga C,Dourado MI,Ximenes RA,Alves L,Brayner F,Rocha A,Alexander N

    更新日期:2003-05-01 00:00:00

  • [Histoplasmin reactivity in poultry farm workers in the province of Ciego de Avila, Cuba].

    abstract::An epidemiological survey with histoplasmin skin test was performed in 392 poultry farmers and 265 workers considered without occupational risk of exposition to Histoplasma capsulatum, etiologic agent of histoplasmosis. The results were positive in 28.8% and 13.2% in both groups respectively. Statistically, there was ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:

    authors: Suárez Hernández M,Fernández Andreu CM,Estrada Ortiz A,Cisneros Despaigne E

    更新日期:1992-07-01 00:00:00

  • Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection.

    abstract::The aim of this study was to validate the rapid lateral flow Helicobacter pylori stool antigen test (One step H. pylori antigen test, ACON laboratories, San Diego, USA; Prime diagnostics, São Paulo), using 13C-Urea Breath Test as the gold standard for H. pylori infection diagnosis. A total of 98 consecutive patients, ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652010000300002

    authors: Silva JM,Villares CA,Monteiro Mdo S,Colaúto C,dos Santos AF,Mattar R

    更新日期:2010-05-01 00:00:00

  • Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha.

    abstract::The response to interferon treatment in chronic hepatitis NANB/C has usually been classified as complete, partial or absent, according to the behavior of serum alanine aminotransferase (ALT). However, a more detailed observation of the enzymatic activity has shown that the patterns may be more complex. The aim of this...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651995000300010

    authors: da Silva LC,Ono SK,Fonseca LE,Carrilho FJ,Mendes LC,França AV,Madruga CL,Laudanna AA

    更新日期:1995-05-01 00:00:00

  • HIF-1alpha and infectious diseases: a new frontier for the development of new therapies.

    abstract::The aim of this review is to show the significant role of HIF-1alpha in inflammatory and infectious diseases. Hypoxia is a physiological characteristic of a wide range of diseases from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydrolase enzymes, which control the protein stability of hypoxia-...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章,评审

    doi:10.1590/S1678-9946201759092

    authors: Santos SAD,Andrade DR Júnior

    更新日期:2017-12-21 00:00:00

  • PREVALENCE OF AMERICAN TRYPANOSOMIASIS AND LEISHMANIASES IN DOMESTIC DOGS IN A RURAL AREA OF THE MUNICIPALITY OF SÃO JOÃO DO PIAUÍ, PIAUÍ STATE, BRAZIL.

    abstract::Chagas disease and the leishmaniases are endemic zoonoses of great importance to public health in the state of Piauí, Brazil. The domestic dog (Canis familiaris) is a major reservoir, host of Trypanosoma cruzi and Leishmania spp. in both urban and rural areas, playing an important role in the transmission of these par...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946201658079

    authors: Perez TD,Figueiredo FB,Junior AA,Silva VL,Madeira MF,Brazil RP,Coura JR

    更新日期:2016-11-03 00:00:00

  • Hand-foot-and-mouth disease epidemiological status and relationship with meteorological variables in Guangzhou, southern China, 2008-2012.

    abstract::Hand-foot-and-mouth disease (HFMD) is becoming one of the extremely common airborne and contact transmission diseases in Guangzhou, southern China, leading public health authorities to be concerned about its increased incidence. In this study, it was used an ecological study plus the negative binomial regression to id...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652014000600014

    authors: Li T,Yang Z,Liu X,Kang Y,Wang M

    更新日期:2014-11-01 00:00:00

  • Long term evaluation of etiological treatment of chagas disease with benznidazole.

    abstract::The aim of this article is to present an investigation of cure rate, after long follow up, of specific chemotherapy with benznidazole in patients with both acute and chronic Chagas disease, applying quantitative conventional serological tests as the base of the criterion of cure. Twenty one patients with the acute for...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cancado JR

    更新日期:2002-01-01 00:00:00

  • Refractory pemphigus vulgaris associated with herpes infection: case report and review.

    abstract:BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering of the skin and mucosa, which develops due to the interaction between predisposing genetic and environmental factors. Infections caused by members of the Herpesviridae family have been suggested as a possible triggering factor for P...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章,评审

    doi:10.1590/s0036-46652011000200010

    authors: Brandão ML,Fernandes NC,Batista DP,Santos N

    更新日期:2011-03-01 00:00:00

  • [Human hydatidosis: field echography for the determination of groups at high risk in the evaluation of a control program].

    abstract::The development of small ultrasonographic equipment has permitted to incorporate this technique to the methods of early detection of Human Hydatidosis. 689 echographies were carried out in this experience, and 5.51% of compatible images in the whole population, and 12.24% in groups of risk (those living together with ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651989000400010

    authors: Larrieu E,Frider B,Andreani G,Andreani G,Aquino A,De La Fuente R

    更新日期:1989-07-01 00:00:00

  • Echinococcus granulosus sensu lato GENOTYPES IN DOMESTIC LIVESTOCK AND HUMANS IN GOLESTAN PROVINCE, IRAN.

    abstract::Cystic echinococcosis (CE) is a globally parasitic zoonosis caused by larval stages of Echinococcus granulosus. This study investigated E. granulosus genotypes isolated from livestock and humans in the Golestan province, northern Iran, southeast of the Caspian sea, using partial sequencing data of the cytochrome c oxi...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946201658038

    authors: Sharbatkhori M,Tanzifi A,Rostami S,Rostami M,Fasihi Harandi M

    更新日期:2016-01-01 00:00:00

  • Re-evaluation of schistosomiasis mansoni in Minas Gerais, Brazil. III. "Noroeste de Minas" mesoregion.

    abstract::This study was conducted to assess the presence of schistosomiasis mansoni in the "Noroeste de Minas" mesoregion, an area considered non-endemic. A malacologic survey and parasitologic stool examinations were undertaken in 13 municipalities of the mesoregion. A sample of 3,283 primary school students was submitted to ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651998000500002

    authors: Carvalho OS,Massara CL,Guerra HL,Campos YR,Caldeira RL,Chaves A,Katz N

    更新日期:1998-09-01 00:00:00

  • Double BR-OVT: a new trap model for collecting eggs and adult mosquitoes from Culex quinquefasciatus and Aedes spp.

    abstract::The circulation of arboviruses throughout the world and the maintenance of lymphatic filariasis endemicity in tropical countries, combined with the lack of vaccines and specific treatments, highlight the importance of reducing the populations of mosquitoes involved in the transmission of these pathogens, Aedes aegypti...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946202062094

    authors: Xavier MDN,Rodrigues MP,Melo DCTV,Santos EMM,Barbosa RMR,Oliveira CMF

    更新日期:2020-11-27 00:00:00

  • Rapid HIV diagnostic test in undocumented pregnant women applied at an inner-city teaching hospital.

    abstract::A significant number of Brazilian gestational-age women are still not tested for HIV, representing a high risk of transmission to their newborns. The current study sought to identify the number of pregnant women with no previous testing or undocumented for HIV referred to the Gynecology and Obstetrics Department of a ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652009000500007

    authors: Prestes-Carneiro LE,Miguel NA,Ascêncio EL,Amâncio M,Alcântara VL,Portelinha-Filho JA

    更新日期:2009-09-01 00:00:00

  • Anopheles (Kerteszia) cruzii (Diptera: Culicidae) in peridomiciliary area during asymptomatic malaria transmission in the Atlantic Forest: molecular identification of blood-meal sources indicates humans as primary intermediate hosts.

    abstract::Anopheles (Kerteszia) cruzii has been implicated as the primary vector of human and simian malarias out of the Brazilian Amazon and specifically in the Atlantic Forest regions. The presence of asymptomatic human cases, parasite-positive wild monkeys and the similarity between the parasites infecting them support the d...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652014000500006

    authors: Kirchgatter K,Tubaki RM,Malafronte Rdos S,Alves IC,Lima GF,Guimarães Lde O,Zampaulo Rde A,Wunderlich G

    更新日期:2014-09-01 00:00:00

  • Mayaro virus: imported cases of human infection in São Paulo State, Brazil.

    abstract::Mayaro virus (MAYV) is an arbovirus (Togaviridae: Alphavirus) enzootic in tropical South America and maintained in a sylvan cycle involving wild vertebrates and Haemagogus mosquitoes. MAYV cases occur sporadically in persons with a history of recent activities inside or around forests. This paper reports three cases o...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652007000400005

    authors: Coimbra TL,Santos CL,Suzuki A,Petrella SM,Bisordi I,Nagamori AH,Marti AT,Santos RN,Fialho DM,Lavigne S,Buzzar MR,Rocco IM

    更新日期:2007-07-01 00:00:00

  • Clinical and laboratory findings of disseminated Mycobacterium avium complex infection (DMAC) in a pair matched case-control study.

    abstract::A pair matched case/control study was conducted from January 1991 to 30 June 1992 in order to define clinical and laboratory findings associated with DMAC infection in AIDS patients. Since DMAC infection is usually associated with advanced immunodeficiency, and therefore also with other opportunistic illnesses, in add...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651999000500002

    authors: Rolla V,Jacomet C,Salause B,Wirbel E,Perez M,Daniel-Ribeiro CT,Rozenbaum W

    更新日期:1999-09-01 00:00:00