当前位置： SCI文献检索 > REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO期刊下所有文献 > Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha.

Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha.

Abstract：

:The response to interferon treatment in chronic hepatitis NANB/C has usually been classified as complete, partial or absent, according to the behavior of serum alanine aminotransferase (ALT). However, a more detailed observation of the enzymatic activity has shown that the patterns may be more complex. The aim of this study was to describe the long term follow-up and patterns of ALT response in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha. A follow-up of 6 months or more after interferon-alpha was achieved in 44 patients. We have classified the serum ALT responses into six patterns and the observed frequencies were as follows: I. Long term response = 9 (20.5%); II. Normalization followed by persistent relapse after IFN = 7 (15.9%); III. Normalization with transient relapse = 5 (11.9%); IV. Temporary normalization and relapse during IFN = 4 (9.1%); V. Partial response (more than 50% of ALT decrease) = 7 (15.9%); VI. No response = 12 (27.3%). In conclusion, ALT patterns vary widely during and after IFN treatment and can be classified in at least 6 types.

journal_name

Rev Inst Med Trop Sao Paulo

journal_title

Revista do Instituto de Medicina Tropical de Sao Paulo

authors

da Silva LC,Ono SK,Fonseca LE,Carrilho FJ,Mendes LC,França AV,Madruga CL,Laudanna AA

doi

10.1590/s0036-46651995000300010

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

239-43

issue

3

eissn

0036-4665

issn

1678-9946

journal_volume

37

pub_type

杂志文章

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