p53 immunostaining pattern in Brazilian patients with hepatocellular carcinoma.

Abstract:

UNLABELLED:Hepatocellular carcinoma (HCC) is an important type of cancer etiologically related to some viruses, chemical carcinogens and other host or environmental factors associated to chronic liver injury in humans. The tumor suppressor gene p53 is mutated in highly variable levels (0-52%) of HCC in different countries. OBJECTIVE:The objective of the present study was to compare the frequency of aberrant immunohistochemical expression of p53 in HCC occurring in cirrhotic or in non-cirrhotic patients as well as in liver cell dysplasia and in adenomatous hyperplasia. We studied 84 patients with HCC or cirrhosis. RESULTS:We detected p53 altered immuno-expression in 58.3% of patients in Grade III-IV contrasting to 22.2% of patients in Grade I-II (p = 0.02). Nontumorous areas either in the vicinity of HCC or in the 30 purely cirrhotic cases showed no nuclear p53 altered expression, even in foci of dysplasia or adenomatous hyperplasia. No significant difference was found among cases related to HBV, HCV or alcohol. CONCLUSION:The high frequency of p53 immunoexpression in this population is closer to those reported in China and Africa, demanding further studies to explain the differences with European and North American reports.

authors

Alves VA,Nita ME,Carrilho FJ,Ono-Nita SK,Wakamatsu A,Lehrbach DM,de Carvalho MF,de Mello ES,Gayotto LC,da Silva LC

doi

10.1590/s0036-46652004000100005

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

25-31

issue

1

eissn

0036-4665

issn

1678-9946

pii

S0036-46652004000100005

journal_volume

46

pub_type

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