Abstract:
:Zika virus (ZIKV) clinical presentation and frequency/duration of shedding need further clarification. Symptomatic ZIKV-infected individuals identified in two hospitals in Sao Paulo State, Brazil, were investigated regarding clinical characteristics, shedding in body fluids, and serodynamics. Ninety-four of 235 symptomatic patients (Site A: 58%; Site B: 16%) had Real-Time PCR-confirmed ZIKV infection; fever, headache and gastrointestinal symptoms were less frequent, and rash was more frequent compared to ZIKV-negative patients. Real-Time PCR in serum had worse performance compared to plasma, while urine had the highest sensitivity. Shedding in genital fluids and saliva was rare. IgM positivity was the highest <14 days after the symptoms onset (86%), decreasing >28 days (24%); IgG positivity increased >14 days (96%) remaining positive in 94% of patients >28 days. ZIKV prevalence varied importantly in two neighboring cities during the same transmission season. Urine Real-Time PCR can improve diagnostic sensitivity; serum testing is less useful. Accurate serological tests are needed to improve diagnosis and surveillance.
journal_name
Rev Inst Med Trop Sao Paulojournal_title
Revista do Instituto de Medicina Tropical de Sao Pauloauthors
Tozetto-Mendoza TR,Avelino-Silva VI,Fonseca S,Claro IM,Paula AV,Levin AS,Sabino EC,Mendes-Correa MC,Figueiredo WM,Felix AC,Souza NCS,Costa AA,Inenami M,Silva RMGD,Levi JE,Romano CM,Paranhos-Baccalà G,Segurado AC,Mayaudoi
10.1590/S1678-9946201961019subject
Has Abstractpub_date
2019-01-01 00:00:00pages
e19eissn
0036-4665issn
1678-9946pii
S0036-46652019005000208journal_volume
61pub_type
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo
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