Temporal association between the isolation of Sabin-related poliovirus vaccine strains and the Guillain-Barré syndrome.

Abstract:

:Thirty eight paralysis cases classified as Guillain-Barré syndrome (GBS) in Brazil were analysed. In all these cases Sabin-related poliovirus vaccine strains were isolated. In most of the cases the last vaccine dose was given months or years before the onset of GBS, suggesting a persistent infection or the transmission of the Sabin-related strains to the patients. The isolation of Sabin-related strains from GBS cases some days or weeks after the onset of the disease, demonstrated a temporal association between the isolation of the strains and the disease. Although the isolates from the GBS cases may not be the etiological agent of the disease, this study strongly indicates that infections caused by Sabin-related vaccine strains can trigger the GBS in certain cases.

authors

Friedrich F,Filippis AM,Schatzmayr HG

doi

10.1590/s0036-46651996000100010

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

55-8

issue

1

eissn

0036-4665

issn

1678-9946

journal_volume

38

pub_type

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