Immune response in mice immunized with acidic antigenic fractions from Trypanosoma cruzi cytosol.

Abstract:

:The humoral and cellular immune responses as well as the resistance to infection with bloodstream forms of T. cruzi were studied in mice immunized with acidic antigenic fractions from parasite cytosol, F III and F IV, plus Bordetella pertussis as adjuvant. The immunization with F III induced positive ITH and DTH responses to homologous antigens. In mice immunized with F IV, the ITH was negative and four out of six animals presented positive DTH reactions. In both groups of mice the analysis of IgG against T. cruzi showed that the major isotype elicited was IgG1. Specific IgE was also detected in sera from F III immunized mice, thus confirming the presence of homocytotropic antibodies. The parasitemias reached by F III and F IV immunized mice after challenge were lower than those of the controls showing in this way a partial protection against the acute infection. The histological studies of heart and skeletal muscle performed two months after the infection revealed variable mononuclear infiltration in all infected mice despite immunization.

authors

Gea S,Gruppi A,Cerban F,Pistoresi Palencia MC,Vottero-Cima E

doi

10.1590/s0036-46651992000500003

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

389-94

issue

5

eissn

0036-4665

issn

1678-9946

journal_volume

34

pub_type

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