Abstract:
:1. Intracellular recordings from neostriatal neurons in an in vitro slice preparation of the rat brain were used to analyze the pharmacological sensitivity of the action potential (AP) repolarization and the afterhyperpolarization (AHP) that follows a single action potential. The interspike voltage trajectory and the AHP could be divided into two main parts: a fast component lasting a few milliseconds and better observed during a train of spikes, and a slow component lasting approximately 250 ms and that comprises the main portion of the AHP. In some cells, a slow (up to 1 s) component of low amplitude was also detected. 2. Single APs were elicited at two imposed membrane potentials (around -60 and around -80 mV). The AP amplitude was larger, the repolarization rate was faster, and the duration was shorter when spikes were evoked at -80 mV. When measured from the -60 mV holding potential, the afterpotential was an AHP with peak amplitude of -5 mV. The afterpotential became a delayed depolarization (DD) at -80 mV. 3. Firing frequency adaptation was voltage sensitive. The firing of APs induced by long intracellular current pulses from a holding potential of -80 mV exhibited only a slow-frequency adaptation (time constant of seconds). However, at -60 mV, an initial and faster frequency adaptation was evident (time constant of tens of milliseconds). 4. The Ca2+ channel blocker Cd2+ retarded AP repolarization rate. This effect correlated with a significant block of the fast and slow components of the AHP. In contrast, Ni2+ had no significant effects on the same parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Pineda JC,Galarraga E,Bargas J,Cristancho M,Aceves Jdoi
10.1152/jn.1992.68.1.287subject
Has Abstractpub_date
1992-07-01 00:00:00pages
287-94issue
1eissn
0022-3077issn
1522-1598journal_volume
68pub_type
杂志文章abstract::The relationship among neonatal seizures, abnormalities of the electroencephalogram (EEG), brain injury, and long-term neurological outcome (e.g., epilepsy) remains controversial. The effects of hypoxia alone (Ha) and hypoxia-ischemia (HI) were studied in neonatal rats at postnatal day 7; both models generate EEG seiz...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00796.2014
更新日期:2015-11-01 00:00:00
abstract::People naturally direct their gaze to visible hand movement goals. Doing so improves reach accuracy through use of signals related to gaze position and visual feedback of the hand. Here, we studied where people naturally look when acting on remembered target locations. Four targets were presented on a screen, in perip...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90518.2008
更新日期:2008-09-01 00:00:00
abstract::Primary motor cortex has been studied for more than a century, yet a consensus on its functional contribution to movement control is still out of reach. In particular, there remains controversy as to the level of control produced by motor cortex ("low-level" movement dynamics vs. "high-level" movement kinematics) and ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00795.2016
更新日期:2017-09-01 00:00:00
abstract::Iontophoresis of glutamate at sites on the apical dendrite 278-555 microm from the somata of rat neocortical pyramidal neurons evoked low-threshold, small, slow spikes and/or large, fast spikes in 71% of recorded cells. The amplitude of the small, slow spikes recorded at the soma averaged 9.1 mV, and their apparent th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.5.2466
更新日期:1997-05-01 00:00:00
abstract::The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the exclusive relay of retinal information en route to the visual cortex. Although much of our understanding about dLGN comes from studies done in higher mammals, such as the cat and primate, the mouse as a model organism has moved to the forefront as a t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00651.2017
更新日期:2018-07-01 00:00:00
abstract::Mutual inhibition between the GABAergic cells of the thalamic reticular nucleus (RTN) is important in regulating oscillations in the thalamocortical network, promoting those in the spindle range of frequencies over those at lower frequencies. Excitatory inputs to the RTN from the cerebral cortex are numerically large ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00624.2003
更新日期:2004-02-01 00:00:00
abstract::We examined the influence of focal cerebellar lesions on working memory (n-back task), gait, and the interaction between working memory and different gait tasks in a dual-task paradigm. The analysis included 17 young patients with chronic focal lesions after cerebellar tumor resection and 17 age-matched controls. Pati...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00062.2013
更新日期:2013-11-01 00:00:00
abstract::The induction of NMDA-receptor-dependent long-term potentiation (LTP) in adult CA1 is contingent on activation of Ca/calmodulin-dependent protein kinase II (CaMKII). However, little is known about kinase mediation of LTP in the dentate gyrus. In the present study, the involvement of the kinases CaMKII, PKA, and MAPK i...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01235.2005
更新日期:2006-06-01 00:00:00
abstract::Adult neuronal phenotype is maintained, at least in part, by the sensitivity of individual neurons to a specific selection of neurotrophic factors and the availability of such factors in the neurons' environment. Nerve growth factor (NGF) increases the functional expression of Na(+) channel currents (I(Na)) and both N...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00966.2007
更新日期:2008-03-01 00:00:00
abstract::The inhibitory circuits of the striatum are known to be critical for motor function, yet their contributions to Parkinsonian motor deficits are not clear. Altered firing in the globus pallidus suggests that striatal medium spiny neurons (MSN) of the direct (D1 MSN) and indirect pathway (D2 MSN) are imbalanced during d...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00382.2013
更新日期:2014-02-01 00:00:00
abstract::Behavioral performance in detection and discrimination tasks is likely to be limited by the quality and nature of the signals carried by populations of neurons in early sensory cortical areas. Here we used voltage-sensitive dye imaging (VSDI) to directly measure neural population responses in the primary visual cortex...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00698.2007
更新日期:2008-03-01 00:00:00
abstract::ACh modulates neuronal activity throughout the cerebral cortex, including the primary visual cortex (V1). However, a number of issues regarding this modulation remain unknown, such as the effect and its function and the receptor subtypes involved. To address these issues, we combined extracellular single-unit recordin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00330.2011
更新日期:2012-01-01 00:00:00
abstract::Interhemispheric interactions through the corpus callosum play an important role in the control of bimanual forces. However, the extent to which physiological connections between primary motor cortices are modulated during increasing levels of bimanual force generation in intact humans remains poorly understood. Here ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00876.2015
更新日期:2016-03-01 00:00:00
abstract::The phasing of neuronal activity in a rhythmic motor network is determined by a neuron's intrinsic firing properties and synaptic inputs; these could vary in their relative importance under different modulatory conditions. In the lobster pyloric network, the firing of eight follower pyloric (PY) neurons is shaped by t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00440.2005
更新日期:2005-11-01 00:00:00
abstract::1. The heart of the nudibranch mollusc Archidoris montereyensis is uniquely responsive to regulation by identifiable cardiac motor neurons. The neurotransmitters mediating the strong excitatory and inhibitory actions of the neurons are unknown. 2. In this study we developed an infused, in vitro preparation of the Arch...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.4.1639
更新日期:1995-10-01 00:00:00
abstract::Electrophysiological recordings show intense neuronal firing during epileptic seizures leading to enhanced energy consumption. However, the relationship between oxygen metabolism and seizure patterns has not been well studied. Recent studies have developed fast and quantitative techniques to measure oxygen microdomain...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00541.2013
更新日期:2014-07-15 00:00:00
abstract::It is well established that locomotor patterns result from the interaction between central pattern generating networks in the nervous system, local feedback from sensory neurons about movements and forces generated in the locomotor organs, and coordinating signals from neighboring segments or appendages. This review a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00615.2004
更新日期:2005-03-01 00:00:00
abstract::Human languages can express opposite propositions by means of the negative operator "not," which turns affirmative sentences into negative ones. Psycholinguistic research has indicated that negative meanings are formed by transiently reducing the access to mental representations of negated conceptual information. Neur...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00894.2012
更新日期:2013-04-01 00:00:00
abstract::An orthodromically evoked late hyperpolarizing potential (LHP) was studied using intracellular recording techniques in rat hippocampal CA1 pyramidal cells in vitro. Several tests indicated that the LHP is not blocked by GABA antagonists, but rather comprises the initial portion of the stimulation-induced burst afterhy...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.52.5.892
更新日期:1984-11-01 00:00:00
abstract::Neurons in both the lateral intraparietal area (LIP) of the monkey parietal cortex and the intermediate layers of the superior colliculus (SC) are activated well in advance of the initiation of saccadic eye movements. To determine whether there is a progression in the covert processing for saccades from area LIP to SC...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.6.2545
更新日期:2001-06-01 00:00:00
abstract::Previous analysis of the firing of individual rat hippocampal place cells has shown that their firing rate increases when they enter a place field and that their phase of firing relative to the ongoing theta oscillation (7-12 Hz) varies systematically as the rat traverses the place field, a phenomenon termed the theta...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.5.2602
更新日期:2000-05-01 00:00:00
abstract::It has recently become clear that microglia, the immune cells of the central nervous system, are far more active in the healthy brain than previously thought. Microglia facilitate many stages of brain development by shaping neuronal connectivity via synaptic elimination. Dysfunction of these same processes likely unde...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00021.2017
更新日期:2018-01-01 00:00:00
abstract::Leopard frog saccular hair cells exhibit an electrical resonance in response to a depolarizing stimulus that has been proposed to contribute to the tuning properties of the frog sacculus by acting as an electrical band-pass filter. With the whole cell patch-clamp technique, we have investigated the effect of temperatu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.1.312
更新日期:1998-01-01 00:00:00
abstract::Rack and Westbury showed that low-frequency asynchronous stimulation of a muscle produces greater force compared with synchronous stimulation. This study tested the hypothesis that the difference results from the dynamic stretch of the common elastic elements. In eight anesthetized cats, the soleus was attached to a s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01304.2005
更新日期:2006-09-01 00:00:00
abstract::The whisker region in the rodent primary motor (MI) cortex receives dense projections from neurons aligned with the layer IV septa in the whisker region of the primary somatosensory (SI) cortex. To compare whisker-induced responses in MI with respect to the SI responses in the septa and adjoining barrel regions, we us...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90327.2008
更新日期:2008-07-01 00:00:00
abstract::Lateral protocerebral interneurons (LPIs) in the central olfactory pathway of the freshwater crayfish Procambarus clarkii reside within the lateral protocerebrum and receive direct input from projection neurons of the olfactory midbrain. The LPIs exhibit periodic (0.5 Hz) changes in membrane potential that are imposed...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.3.1231
更新日期:1999-03-01 00:00:00
abstract::In this study we analyzed transient voltage-activated K+ currents (IA) of projection neurons and local interneurons in the antennal lobe of the cockroach Periplaneta americana The antennal lobe is the first synaptic processing station for olfactory information in insects. Local interneurons are crucial for computing o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00685.2016
更新日期:2017-05-01 00:00:00
abstract::Mature stellate cells of the rat medial entorhinal cortex (EC), layer II, exhibit subthreshold membrane potential oscillations (MPOs) at theta frequencies (4-12 Hz) in vitro. We find that MPOs appear between postnatal days 14 (P14) and 18 (P18) but show little further change by day 28+ (P28-P32). To identify the facto...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90424.2008
更新日期:2008-12-01 00:00:00
abstract::Transcranial magnetic stimulation (TMS) is increasingly used to modify brain activity noninvasively and to study brain-behavior relations. However, results can be variable and the conditions that affect the functional efficacy of TMS remain unclear. Here we show that on-line TMS can either facilitate or suppress perce...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01392.2007
更新日期:2008-05-01 00:00:00
abstract::Multiple studies have demonstrated that brain-derived neurotrophic factor (BDNF) is a potent modulator of neuronal structure and function in the hippocampus. However, the majority of studies to date have relied on the application of recombinant BDNF. We herein report that endogenous BDNF, released via theta burst stim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01140.2009
更新日期:2010-05-01 00:00:00