Abstract:
:The induction of NMDA-receptor-dependent long-term potentiation (LTP) in adult CA1 is contingent on activation of Ca/calmodulin-dependent protein kinase II (CaMKII). However, little is known about kinase mediation of LTP in the dentate gyrus. In the present study, the involvement of the kinases CaMKII, PKA, and MAPK in the induction of LTP was studied in the dentate gyrus of adult rats. Individual application of selective inhibitors of CaMKII, MEK, or PKA did not inhibit induction of LTP. In contrast, coapplication of a CaMKII inhibitor with either a PKA or MEK inhibitor resulted in a strong block of LTP. Induction of LTP was blocked by the coapplication of the inhibitors CaMKII and PKA or MEK, both when they were applied 1 h before the induction stimulus and also when they were applied after the induction stimulus. Thus LTP is mediated by either of two parallel cascades, one involving CaMKII and the other PKA or MAPK. Moreover, these cascades are active for a certain period after the induction stimulus.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Wu J,Rowan MJ,Anwyl Rdoi
10.1152/jn.01235.2005subject
Has Abstractpub_date
2006-06-01 00:00:00pages
3519-27issue
6eissn
0022-3077issn
1522-1598pii
95/6/3519journal_volume
95pub_type
杂志文章abstract::Recent work in the anterior piriform cortex (aPCX) has demonstrated that cortical odor receptive fields are highly dynamic, showing rapid changes of both firing rate and temporal patterning within relatively few inhalations of an odor, despite relatively maintained, patterned input from olfactory bulb mitral/tufted ce...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
abstract::Changes to cerebral miRNA expression have been implicated in the progression of Alzheimer's disease (AD), as miRNAs that regulate the expression of gene products involved in amyloid beta (Aβ) processing, such as BACE1, are dysregulated in those that suffer from AD. Exercise training improves cognition and reduces BACE...
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1152/jn.00256.2010
更新日期:2010-11-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.1.290
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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更新日期:2013-08-01 00:00:00
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更新日期:2009-04-01 00:00:00
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journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:1991-11-01 00:00:00