Abstract:
PURPOSE:To develop a semiquantitative magnetic resonance (MR) imaging bone marrow burden (BMB) score with inclusion of both axial and peripheral bone marrow in Gaucher disease as an alternative to MR imaging with the Dixon quantitative chemical shift imaging (QCSI) technique. MATERIALS AND METHODS:Two experienced musculoskeletal radiologists with no experience in evaluating Gaucher disease blindly analyzed MR images of lumbar spines and femora. Interobserver and intraobserver variability were tested. In addition, the BMB score was determined as a parameter to evaluate bone marrow response to enzyme supplementation therapy. Finally, the BMB score was compared with fat fraction measurements obtained with Dixon QCSI. Differences between groups were analyzed by using the nonparametric Mann-Whitney test. A P value of less than.05 was considered to represent significance. Correlation was calculated by using two-tailed nonparametric rank correlation (Spearman rho). RESULTS:In 30 patients (mean age, 39.3 years; age range, 12-71 years) the mean fat fraction was 0.20 (range, 0.08-0.40). The BMB score range was 3-13 points. A significant correlation was found between the two observers when using BMB (rho = 0.91, P <.001). The intraobserver variation showed a significant correlation (rho = 0.99, P <.001). There was a significant correlation between BMB and QCSI (rho = -0.78, P <.001). Although BMB was less sensitive than Dixon QCSI, it showed enough sensitivity to allow detection of bone marrow response to enzyme supplementation therapy. CONCLUSION:BMB is a reproducible semiquantitative scoring system that is easy to use. It combines MR imaging of both axial and peripheral bone marrow and shows a significant correlation with QCSI.
journal_name
Radiologyjournal_title
Radiologyauthors
Maas M,van Kuijk C,Stoker J,Hollak CE,Akkerman EM,Aerts JF,den Heeten GJdoi
10.1148/radiol.2292020296subject
Has Abstractpub_date
2003-11-01 00:00:00pages
554-61issue
2eissn
0033-8419issn
1527-1315pii
2292020296journal_volume
229pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To prospectively determine in swine the effects of cardiac-specific and hypoxia-inducible vascular endothelial growth factor (VEGF) expression gene on angiogenesis and arteriogenesis by using cardiovascular magnetic resonance (MR) imaging for evaluation of infarct resorption and left ventricular (LV) function. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2432060928
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To determine the feasibility and accuracy of a protocol for calculating whole-organ renal perfusion (renal blood flow [RBF]) and regional perfusion on the basis of biphasic computed tomography (CT), with concurrent dynamic contrast material-enhanced (DCE) CT perfusion serving as the reference standard. MATERIA...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2015142757
更新日期:2016-04-01 00:00:00
abstract::Purpose To evaluate the associations among mathematical modeling with the use of magnetic resonance (MR) imaging-based texture features and deep myometrial invasion (DMI), lymphovascular space invasion (LVSI), and histologic high-grade endometrial carcinoma. Materials and Methods Institutional review board approval wa...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2017161950
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To prospectively determine the accuracy of combination positron emission tomography-computed tomography (PET/CT) in lymph node staging in patients with early-stage cervical cancer, with histopathologic results as the reference standard. MATERIALS AND METHODS:The study was institutional review board approved, a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2381041799
更新日期:2006-01-01 00:00:00
abstract::Institutional review board approval and written informed consent were obtained. The purpose of this study was to prospectively validate usefulness of diffusion-tensor (DT) fiber tractography of the corticospinal tract at 3-T magnetic resonance imaging, in combination with the subcortical motor-evoked potential (MEP) t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2403050916
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:To investigate at which age testicular blood flow can be demonstrated consistently by color Doppler sonography and power Doppler sonography. MATERIALS AND METHODS:In this prospective study, 172 normal testes of 86 boys (age range, 4 days to 15 years) were examined with gray-scale ultrasound, color Doppler sono...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.202.2.9015090
更新日期:1997-02-01 00:00:00
abstract::To clarify the anatomy of the peritoneal reflections of the left perihepatic region, the authors examined 95 cadavers. Thirty-eight were studied radiographically, 37 with sagittal dissection, and 20 with transverse dissection. In over 80% of the cadavers, the left triangular ligament of the liver separated the left su...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.182.2.1732980
更新日期:1992-02-01 00:00:00
abstract::On rare occasions, excessive lipase production by functioning pancreatic acinar cell carcinoma results in subcutaneous and intraosseous fat necrosis. A patient with subcutaneous nodules and osteolytic lesions from metastatic fat necrosis associated with this malignancy is reported. Prompt recognition of the syndrome l...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.158.1.3940400
更新日期:1986-01-01 00:00:00
abstract::The radionuclide, radiographic and pathologic findings in a patient with progressive multifocal leukoencephalopathy were correlated. Radionuclide imaging demonstrated the largest two of the many lesions observed at pathology. On repeated studies, one of the lesions developed a "doughnut" sign due to central necrosis. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/119.2.399
更新日期:1976-05-01 00:00:00
abstract:PURPOSE:To evaluate whether contrast material-enhanced (CE) fast imaging employing steady-state acquisition (FIESTA) can depict the anterior optic pathways in patients with large suprasellar tumors. MATERIALS AND METHODS:Institutional review board approval was obtained. Twenty-eight patients with large suprasellar tum...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.12111363
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To assess diagnostic accuracy of preoperatively performed magnetic resonance (MR) imaging for detection of tumor extent in a large patient population with histopathologically proved retinoblastoma. MATERIALS AND METHODS:Local ethics committee approval and informed consent were not required for retrospective re...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2351031301
更新日期:2005-04-01 00:00:00
abstract::Using a method combining the velocity of ultrasound and photon absorptiometry in the human radius in vivo, the authors measured the speed of sound in bone (U) and bone mineral content (BMC). From these measurements and a "simple" bone model, they then computed the bone mineral density, compact bone density, and modulu...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.138.3.7465850
更新日期:1981-03-01 00:00:00
abstract::Background Increased cerebral signal intensity (SI) has been reported in patients undergoing MRI with gadolinium-based contrast agents (GBCAs). Published data on gadobenate dimeglumine have been somewhat contradictory. Purpose To evaluate the relationship between dosage of gadobenate dimeglumine and SI change at MRI f...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2020190246
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To assess emergency ultrasonography (US) for detection of bowel and mesenteric injury from blunt trauma. MATERIALS AND METHODS:For 3 years, prospective data on all patients undergoing emergency US were recorded. Patients with bowel and mesenteric injury were identified, and physical examination, laboratory, co...
journal_title:Radiology
pub_type: 临床试验,杂志文章
doi:10.1148/radiology.211.2.r99ma54399
更新日期:1999-05-01 00:00:00
abstract:PURPOSE:To examine relationships between brain white matter hyperintensities depicted at magnetic resonance (MR) imaging and performance on neuropsychologic tests in community-dwelling elderly adults. MATERIALS AND METHODS:The 1921 Aberdeen Birth Cohort is a subsample of survivors of the Scottish Mental Survey of 1932...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2211010086
更新日期:2001-10-01 00:00:00
abstract::Preoperative B-mode ultrasonography was performed on 7 infants who subsequently were surgically proved to have multicystic kidney disease. Five of the 7 showed a characteristic pattern consisting of a predominantly cystic mass containing septa which divided it into cysts of varying sizes. It is concluded that ultrasou...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/118.3.685
更新日期:1976-03-01 00:00:00
abstract:PURPOSE:To determine whether magnetic resonance (MR) spectroscopic imaging reveals metabolic changes, especially decreased N-acetylaspartate (NAA) concentrations outside the medial temporal lobe in patients with mesial temporal lobe epilepsy (TLE), consistent with neuropathologic findings of extratemporal neuronal impa...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2261011668
更新日期:2003-01-01 00:00:00
abstract::A review was made of 219 transcatheter vessel occlusion procedures performed over a ten-year period for control of hemorrhage, tumor palliation, or blood supply redistribution prior to intra-arterial chemotherapy. Complete angiographic success was obtained in 85% of the procedures, with partial success in 8%; complete...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.147.1.6828710
更新日期:1983-04-01 00:00:00
abstract::Purpose To determine whether fructose 1,6-bisphosphatase 1 (FBP1) expression is associated with fluorine 18 (18F) fluorodeoxyglucose (FDG) accumulation in patients with hepatocellular carcinoma (HCC) and to investigate how FBP1 expression and 18F FDG uptake are related to tumor differentiation grade and metabolism and...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2017161607
更新日期:2017-09-01 00:00:00
abstract::Vertebral mineral loss (measured by computed tomography) was compared to peripheral mineral loss (measured by photon absorptiometry) in immobilized monkeys. Significantly greater loss was found in axial cancallous bone than in peripheral cortical bone. The accuracy of vertebral CT measurements in one animal was determ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.134.2.6766220
更新日期:1980-02-01 00:00:00
abstract:PURPOSE:To assess SH U 508A in the diagnosis of suspected renal arterial stenosis by means of ultrasonography (US) and to confirm the safety of SH U 508A in a clinical setting. MATERIALS AND METHODS:A randomized crossover study was performed in 198 patients from 14 European centers who were referred for renal arterial...
journal_title:Radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1148/radiology.214.3.r00fe02739
更新日期:2000-03-01 00:00:00
abstract::In a study group of 18 consecutive patients with Ewing sarcoma proved by means of biopsy, the signal intensity characteristics of tumor on magnetic resonance (MR) images were assessed before and after chemotherapy. Sixteen patients underwent MR imaging at 1.5 T before chemotherapy; all 18 patients underwent MR imaging...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.184.3.1509080
更新日期:1992-09-01 00:00:00
abstract::Fluoroscopically guided percutaneous needle aspiration of focal pulmonary lesions was performed in 108 presumed infectious episodes in 82 immunocompromised patients in whom prior diagnostic studies, including transtracheal aspiration, were negative to inconclusive. Two-thirds of the lesions were 4 cm or smaller. Singl...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/132.3.563
更新日期:1979-09-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of T2-weighted fast spin-echo magnetic resonance (MR) imaging with a 512 x 256 matrix for assessment of the preoperative stage of endometrial carcinoma. MATERIALS AND METHODS:Twenty-eight women with histopathologically proved endometrial carcinoma underwent preoperative T2-weighted f...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.206.2.9457210
更新日期:1998-02-01 00:00:00
abstract::Three patients presented with meningitis associated with congenital defects of the inner ear, consisting of a cyst-like cochlea and a short, wide horizontal semicircular canal. The findings were easily identified on routine skull radiographs, alleviating the need for further studies and leading to treatment of the def...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.135.2.7367630
更新日期:1980-05-01 00:00:00
abstract::Quantitative microstructural sonography differs from conventional sonography in several ways. The frequency as well as the amplitude of echoes is recorded and assessed using spectral analysis techniques. The effects of diffraction of the ultrasound beam are calibrated, as are the transfer characteristics of the system...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.155.2.2984720
更新日期:1985-05-01 00:00:00
abstract::Shoulder arthrography is a reliable technique for use in the diagnosis of tears of the rotator cuff, although delineation of the precise site and size of tears requires meticulous double-contrast technique and considerable examiner expertise. The authors initiated a prospective evaluation of digital arthrography of th...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.168.3.3406400
更新日期:1988-09-01 00:00:00
abstract:PURPOSE:To assess the prevalence and degree of lumbosacral transitional vertebrae (LSTV) in the Osteoarthritis Initiative (OAI) cohort, to assess whether LSTV correlates with low back pain (LBP) and buttock pain, and to assess the reproducibility of grading LSTV. MATERIALS & METHODS:Institutional review board approval...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.12112747
更新日期:2012-11-01 00:00:00
abstract::In a review of the records of 3,712 drug abusers, 13 patients were identified with neurologic deficits attributable to the use of cocaine. Ischemic manifestations were the most frequent, occurring in seven (54%) patients, with a mean age of 34.2 years. Three (23%) patients had subarachnoid hemorrhage, and three (23%) ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.170.1.2909100
更新日期:1989-01-01 00:00:00
abstract::In a patient with choledocholithiasis, a duodenal diverticulum precluded endoscopic retrograde bile duct cannulation. A transhepatic catheter was used to opacify the bile ducts and to guide the endoscopic sphincterotome into the major duodenal papilla. Because limited sphincterotomy did not allow extraction or spontan...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.165.2.3116600
更新日期:1987-11-01 00:00:00