Abstract:
:Purpose To evaluate the associations among mathematical modeling with the use of magnetic resonance (MR) imaging-based texture features and deep myometrial invasion (DMI), lymphovascular space invasion (LVSI), and histologic high-grade endometrial carcinoma. Materials and Methods Institutional review board approval was obtained for this retrospective study. This study included 137 women with endometrial carcinomas measuring greater than 1 cm in maximal diameter who underwent 1.5-T MR imaging before hysterectomy between January 2011 and December 2015. Texture analysis was performed with commercial research software with manual delineation of a region of interest around the tumor on MR images (T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced images and apparent diffusion coefficient maps). Areas under the receiver operating characteristic curve and diagnostic performance of random forest models determined by using a subset of the most relevant texture features were estimated and compared with those of independent and blinded visual assessments by three subspecialty radiologists. Results A total of 180 texture features were extracted and ultimately limited to 11 features for DMI, 12 for LVSI, and 16 for high-grade tumor for random forest modeling. With random forest models, areas under the receiver operating characteristic curve, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were estimated at 0.84, 79.3%, 82.3%, 81.0%, 76.7%, and 84.4% for DMI; 0.80, 80.9%, 72.5%, 76.6%, 74.3%, and 79.4% for LVSI; and 0.83, 81.0%, 76.8%, 78.1%, 60.7%, and 90.1% for high-grade tumor, respectively. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of visual assessment for DMI were 84.5%, 82.3%, 83.2%, 77.7%, and 87.8% (reader 3). Conclusion The mathematical models that incorporated MR imaging-based texture features were associated with the presence of DMI, LVSI, and high-grade tumor and achieved equivalent accuracy to that of subspecialty radiologists for assessment of DMI in endometrial cancers larger than 1 cm. However, these preliminary results must be interpreted with caution until they are validated with an independent data set, because the small sample size relative to the number of features extracted may have resulted in overfitting of the models. © RSNA, 2017 Online supplemental material is available for this article.
journal_name
Radiologyjournal_title
Radiologyauthors
Ueno Y,Forghani B,Forghani R,Dohan A,Zeng XZ,Chamming's F,Arseneau J,Fu L,Gilbert L,Gallix B,Reinhold Cdoi
10.1148/radiol.2017161950subject
Has Abstractpub_date
2017-09-01 00:00:00pages
748-757issue
3eissn
0033-8419issn
1527-1315journal_volume
284pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::Gadolinium chelates, intended as intravenous contrast media for magnetic resonance imaging, have been regarded as nonnephrotoxic and recommended to replace iodinated contrast media in patients with azotemia who are undergoing digital subtraction angiography (DSA). High intraarterial doses (up to 220 mmol of gadodiamid...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2232010221
更新日期:2002-05-01 00:00:00
abstract::The lateral C1-2 puncture approach for myelography is a modification of the technique for percutaneous radiofrequency cervical cordotomy. Positioning of the needle in the posterior, rather than anterior, one third of the canal avoids injury to anomalous vertebral artery branches which lie in the anterior half of the n...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/132.3.760
更新日期:1979-09-01 00:00:00
abstract::Thirty-two patients with a known primary malignancy and a symptomatic malignant pleural effusion underwent small-bore-catheter thoracostomy and talc pleurodesis. Twenty-three patients (72%) had a complete response; four (12%), a partial response; and five (16%), no response. Symptoms in all those who responded were cl...
journal_title:Radiology
pub_type: 临床试验,杂志文章
doi:10.1148/radiology.210.1.r99dc04277
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To determine whether systematically evaluated criteria for probably benign lesions were actually applied to lesions placed into that category. MATERIALS AND METHODS:A search of the mammography database yielded 295 cases that were initially followed up with short-term interval mammography but eventually receive...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2231011355
更新日期:2002-04-01 00:00:00
abstract::A percutaneous technique is described for the introduction of Kimray-Greenfield filters into the vena cava through either the internal jugular or femoral approach. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.151.2.6709930
更新日期:1984-05-01 00:00:00
abstract::Circular esophageal myotomy of the upper pouch in infants with esophageal atresia is an effective means of reducing anastomotic tension. This report describes two patients who developed marked postoperative dilatation of the proximal esophagus at the myotomy site. On radiographs, the dilated, air-filled esophagus simu...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.136.2.7403510
更新日期:1980-08-01 00:00:00
abstract:PURPOSE:To evaluate the effect of the increase in total cross-sectional area of arteries as they branch beyond the main trunks on the resistive index (RI) and early systolic acceleration (ESA). MATERIALS AND METHODS:An essentially noncompliant in vitro model that used a pulsatile pump, blood-mimicking fluid, and a bra...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.212.3.r99se13732
更新日期:1999-09-01 00:00:00
abstract::Seventy-five spot compression views of equivocally suspicious lesions detected at routine mammographic examination of 72 women were reviewed in this retrospective study. Sixty-five of the 75 lesions appeared less suspicious on spot compression views, two did not change, and eight appeared more suspicious. Biopsy findi...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.171.2.2704800
更新日期:1989-05-01 00:00:00
abstract:PURPOSE:To determine the accuracy of magnetic resonance (MR) cholangiography for detection of primary sclerosing cholangitis (PSC) and localization of PSC in the biliary tract. MATERIALS AND METHODS:In a prospective case-control study involving 102 patients, the MR cholangiograms obtained in 34 patients with PSC estab...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.215.1.r00ap2671
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To compare anatomic alignment between morphologic and positron emission tomography (PET) images acquired in the abdomen and pelvis by using simultaneous magnetic resonance (MR)/PET, PET/computed tomography (CT), and retrospective MR/PET fusion and to compare alignment between MR and PET in simultaneous and sequ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.13121838
更新日期:2013-07-01 00:00:00
abstract::Obliteration of varicoceles in men with infertility has been shown to improve semen quality and increase fertility rates. Many current techniques involve complex procedures and specialized equipment and may be associated with adverse effects. Transcatheter thermal vessel occlusion was utilized for spermatic vein oblit...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.148.1.6856870
更新日期:1983-07-01 00:00:00
abstract::A simplified method for constructing a custom-made mold to hold radium for intracavitary radiation therapy of recurrent nasopharyngeal carcinoma was developed. The technique for fabrication and insertion of the mold in a single operative procedure is described. Computer dose distributions were obtained and the applica...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/131.2.534
更新日期:1979-05-01 00:00:00
abstract:PURPOSE:To compare and evaluate the measures of costs for core-needle and surgical breast biopsies. MATERIALS AND METHODS:Three measures of costs were evaluated: (a) input resources, (b) actual payments, and (c) billed charges. A combination of methods were used for data collection from 10 sites enrolled in a large-sc...
journal_title:Radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1148/radiology.212.1.r99jl46181
更新日期:1999-07-01 00:00:00
abstract::Purpose To cross-validate T1-weighted oxygen-enhanced (OE) MRI measurements of tumor hypoxia with intrinsic susceptibility MRI measurements and to demonstrate the feasibility of translation of the technique for patients. Materials and Methods Preclinical studies in nine 786-0-R renal cell carcinoma (RCC) xenografts an...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018171531
更新日期:2018-09-01 00:00:00
abstract::Sensitivity and specificity of lumbar spine radiography in the assessment of facet joint osteoarthritis were evaluated, with computed tomography (CT) as the standard. Two independent radiologists used a four-point scale to blindly grade facet joint osteoarthritis on oblique radiographs and transaxial CT scans obtained...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.164.1.3588910
更新日期:1987-07-01 00:00:00
abstract:PURPOSE:To examine whether the different appearances of intramedullary high signal intensity (SI) on T2-weighted MR images in cervical spondylotic myelopathy are related to differences in surgical prognosis. MATERIALS AND METHODS:The magnetic resonance (MR) findings and Japanese Orthopedic Association (JOA) score of 6...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2213010365
更新日期:2001-12-01 00:00:00
abstract:PURPOSE:To prospectively determine in swine the effects of cardiac-specific and hypoxia-inducible vascular endothelial growth factor (VEGF) expression gene on angiogenesis and arteriogenesis by using cardiovascular magnetic resonance (MR) imaging for evaluation of infarct resorption and left ventricular (LV) function. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2432060928
更新日期:2007-05-01 00:00:00
abstract::Purpose To determine if the combination of high cerebral blood flow (CBF) and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is associated with benefit from a second round of low-dose temozolomide (TMZ) (ie, rechallenge) in patients with glioblastoma at first recurrence. Materials and Methods The i...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2016152152
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To determine predictors of clot dissolution in patients undergoing catheter-directed urokinase thrombolysis for peripheral arterial occlusion (PAO). MATERIALS AND METHODS:The study included 103 patients with limb-threatening symptoms of embolism lasting 14 days or less and resulting from embolism (n = 20) or t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.193.2.7972780
更新日期:1994-11-01 00:00:00
abstract::Subtraction radiography permits the use of 7-10 times less contrast material than is required without subtraction techniques. The first-order, second-order, and composite mask techniques are described and evaluated. While the second-order technique gives more complete cancellation of common structures, the more common...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/124.1.65
更新日期:1977-07-01 00:00:00
abstract:PURPOSE:To retrospectively describe the magnetic resonance (MR) imaging characteristics of normal breast tissue and breast cancer in the setting of lactation. MATERIALS AND METHODS:The HIPAA-compliant study was exempt from institutional approval, and informed consent was not required. Unilateral MR imaging of 10 breas...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2372040837
更新日期:2005-11-01 00:00:00
abstract::In order to examine the effects of bacteriuria on renal growth and scarring, 208 schoolgirls aged 5 to 12 years, in whom bacteriuria was detected during a screening program, were followed for 4 years. Of these, 110 were treated. Excretory urography and micturating cystography were performed at the start and end of the...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/132.2.343
更新日期:1979-08-01 00:00:00
abstract:PURPOSE:To determine whether fetal growth measured at serial ultrasonographic (US) examinations can predict neonatal morbidity, independent of whether gestational age is known. MATERIALS AND METHODS:Women (n = 321) who had singleton pregnancies and underwent two or more second- or third-trimester obstetric US examinat...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2231010876
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:To determine the prognostic importance of periintervention serum levels of acute-phase reactants in 6-month restenosis after stent implantation in the carotid artery. MATERIALS AND METHODS:One hundred eight consecutive patients with 70% or greater stenosis of the internal carotid artery (ICA) according to the ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2272020183
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To assess the feasibility of percutaneous magnetic resonance (MR)-guided intramyocardial injection of gadodiamide by using real-time imaging and to quantify T1 values and the size of the enhanced region for different concentrations of contrast agent for 30 minutes after injection. MATERIALS AND METHODS:Animal ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2352031760
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To investigate if magnetic resonance (MR) enteroclysis can be performed routinely and to compare MR enteroclysis findings with those of conventional enteroclysis or surgery. MATERIALS AND METHODS:MR enteroclysis was prospectively performed in 30 patients with symptoms of inflammatory bowel disease or small-bow...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.215.3.r00jn12717
更新日期:2000-06-01 00:00:00
abstract::Areas of sclerosis in the phalanges, particularly the terminal phalanges, are common in sarcoidosis despite the rarity of osteosclerotic changes in other bones. Of 37 patients with sarcoidosis with osseous changes of the hands or feet, 20 (54%) has sclerosis either alone or in combination with bone destruction. Of 48 ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/115.2.279
更新日期:1975-05-01 00:00:00
abstract::Purpose To develop and validate a deep learning algorithm that predicts the final diagnosis of Alzheimer disease (AD), mild cognitive impairment, or neither at fluorine 18 (18F) fluorodeoxyglucose (FDG) PET of the brain and compare its performance to that of radiologic readers. Materials and Methods Prospective 18F-FD...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018180958
更新日期:2019-02-01 00:00:00
abstract::In tumor radiobiology, the hypoxic cell has become especially important because of recent evidence of acute hypoxic regions within experimental tumors. The impact of hyperthermia on the development of acute hypoxia is discussed. Two experiments for studying hyperthermia and hypoxia in tumors are presented. Knowledge o...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiology.137.3.7003650
更新日期:1980-12-01 00:00:00
abstract::Failures and complications were analyzed retrospectively in 45 patients treated with embolotherapy or occlusion of pulmonary arterial circulation. Pulmonary arterial branches were occluded with steel coils in 19 patients with pulmonary arteriovenous malformations, 17 with hemoptysis of pulmonary artery (PA) origin, an...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.180.3.1871280
更新日期:1991-09-01 00:00:00