DNA damage and repair in Gorlin syndrome and normal fibroblasts after aminolevulinic acid photodynamic therapy: a comet assay study.

abstract：:The response of normal brain to photodynamic therapy (PDT) was investigated in 62 Fisher rats. The animals were injected i.p. with Photofrin II (12.5 mg/kg). Forty-eight hours following injection, an area of dura 5 mm in diameter over the frontal cortex was photoactivated with red light (632 +/- 2 nm) at 100 mW cm-2, ...

journal_title：Photochemistry and photobiology

authors： Dereski MO,Chopp M,Garcia JH,Hetzel FW

更新日期：1991-07-01 00:00:00

abstract：:The in vitro cell survival, localization and ultrastructural changes following irradiation were examined in 9L glioma cells sensitized with a new photosensitizer, lysyl chlorin p6 (LCP). In clonogenic assays, LCP was 10-100-fold more phototoxic than photofrin II on a microgram/mL basis. Lysyl chlorin p6 uptake was blo...

journal_title：Photochemistry and photobiology

authors： Leach MW,Higgins RJ,Autry SA,Boggan JE,Lee SJ,Smith KM

更新日期：1993-11-01 00:00:00

abstract：:Ultraviolet A radiation participates in cytotoxicity and carcinogenesis of the skin by a mechanism involving the generation of reactive oxygen species. Endogenous antiradical defense systems utilize metalloenzymes including Se-dependent glutathione peroxidase and Cu and Zn superoxide dismutase. The aim of the present ...

journal_title：Photochemistry and photobiology

authors： Leccia MT,Richard MJ,Beani JC,Faure H,Monjo AM,Cadet J,Amblard P,Favier A

更新日期：1993-10-01 00:00:00

abstract：:The inefficient endosomal escape of drugs or macromolecules is a major obstacle to achieving successful delivery to therapeutic targets. An efficient approach to circumvent this barrier is photochemical internalization (PCI), which uses light and photosensitizers for endosomal escape of the delivered macromolecules. T...

journal_title：Photochemistry and photobiology

authors： Soe TH,Nanjo T,Watanabe K,Ohtsuki T

更新日期：2019-11-01 00:00:00

abstract：:The proteins induced by heat and other stressors, called heat shock proteins (HSP) or stress proteins, are considered to play a general role in protection from cellular injury. Exposure to UVA (320-400 nm) following application of 8-methoxypsoralen (8-MOP), termed PUVA is commonly used in the field of dermatology. In ...

journal_title：Photochemistry and photobiology

authors： Muramatsu T,Yamashina Y,Tada H,Kobayashi N,Yamaji M,Ohno H,Shirai T,Takahashi A,Ohnishi T

更新日期：1993-12-01 00:00:00

abstract：:Mitochondria have been implicated as a primary subcellular site of porphyrin localization and photodestruction. However, other organelles including the cell membrane, lysosomes and nucleus have been shown to be damaged by hematoporphyrin derivative (HpD) photosensitized destruction as well. In this study we attempted ...

journal_title：Photochemistry and photobiology

authors： Shulok JR,Wade MH,Lin CW

更新日期：1990-04-01 00:00:00

abstract：:Aqueous solutions of KI were examined for use as chemical actinometers to measure 254 nm (germicidal) radiation. Irradiation results in electron ejection from iodide such that aqueous electrons and iodine atoms are formed. In the presence of N2O, an electron scavenger, recombination of these two reactive species is el...

journal_title：Photochemistry and photobiology

authors： Rahn RO

更新日期：1993-12-01 00:00:00

abstract：:Luciferin-regenerating enzyme (LRE) contributes to in vitro recycling of D-luciferin. In this study, reinvestigation of the luciferase-based LRE assay is reported. Here, using quick change site-directed mutagenesis seven T-LRE (Lampyris turkestanicusLRE) mutants were constructed and the most functional mutant of T-LRE...

journal_title：Photochemistry and photobiology

authors： Hemmati R,Hosseinkhani S,Sajedi RH,Azad T,Tashakor A,Bakhtiari N,Ataei F

更新日期：2015-07-01 00:00:00

abstract：:The phototoxic anti-hyperlipoproteinemic drug fenofibrate was found to be photolabile under aerobic and anaerobic conditions. Irradiation under argon of a methanol solution of this drug produced the photoproducts isopropyl 4-(1-[4-chlorophenyl]-1,2-dihydroxy)ethylphenoxyisobutyrate, 1,2-bis(4-chlorophenyl)-1,2bis (4-[...

journal_title：Photochemistry and photobiology

authors： Vargas F,Canudas N,Miranda MA,Boscá F

更新日期：1993-10-01 00:00:00

abstract：:It is generally assumed that a central metal is essential for the efficiency of phthalocyanines in photodynamic therapy (PDT) of cancer. Contrary to the set opinion, the results of the present study indicate that the metal-free sulfonated phthalocyanines (H2PcSn, where n is the number of sulfonate groups per molecule)...

journal_title：Photochemistry and photobiology

authors： Feofanov A,Grichine A,Karmakova T,Kazachkina N,Pecherskih E,Yakubovskaya R,Luk'yanets E,Derkacheva V,Egret-Charlier M,Vigny P

更新日期：2002-05-01 00:00:00

abstract：:High temperature can promote cyanobacterial blooms, whereas ultraviolet radiation (UVR) can potentially depress cyanobacterial growth by damaging their photosynthetic apparatus. Although the damaging effect of UVR has been well documented, reports on the interactive effects of UV radiation exposure and warming on cyan...

journal_title：Photochemistry and photobiology

authors： Noyma NP,Mesquita MCB,Roland F,Marinho MM,Huszar VLM,Lürling M

更新日期：2021-01-04 00:00:00

abstract：:UV-induced toxicity is characterized by marked oxidative stress, accompanied by the depletion of key cellular antioxidants, particularly glutathione (GSH). Replenishing cellular GSH may represent a means of counteracting UV-induced toxicity: however, treatment with free GSH is not therapeutically effective due to its ...

journal_title：Photochemistry and photobiology

authors： Wright D,Zampagni M,Evangelisti E,Conti S,D'Adamio G,Goti A,Becatti M,Fiorillo C,Taddei N,Cecchi C,Liguri G

更新日期：2013-03-01 00:00:00

abstract：:Photochemo and photodynamic therapies are minimally invasive approaches for the treatment of cancers and powerful weapons for competing bacterial resistance to antibiotics. Synthetic and naturally occurring quinazolinones are considered privileged anticancer and antibacterial agents, with several of them to have emerg...

journal_title：Photochemistry and photobiology

authors： Panagopoulos A,Balalas T,Mitrakas A,Vrazas V,Katsani KR,Koumbis AE,Koukourakis MI,Litinas KE,Fylaktakidou KC

更新日期：2021-01-01 00:00:00

abstract：:The marine annelid Chaetopterus variopedatus produces bioluminescence by an unknown and potentially novel mechanism. We have advanced the study of this fascinating phenomenon, which has not been investigated for nearly 60 years after initial studies were first reported for this species. Here, we show that the luminous...

journal_title：Photochemistry and photobiology

authors： Branchini BR,Behney CE,Southworth TL,Rawat R,Deheyn DD

更新日期：2014-01-01 00:00:00

abstract：:Tin oxide nanoparticles about 4 nm in size were successfully synthesized using hydrothermal method. The photocatalytic activity of the particles was determined by the decolorization of malachite green (MG) and titanium yellow (TY) under UV light. 12 ppm of MG and TY were used for the solution with an initial volume of...

journal_title：Photochemistry and photobiology

authors： Esen B,Yumak T,Sınağ A,Yıldız T

更新日期：2011-03-01 00:00:00

abstract：:Proton magnetic resonance imaging (MRI) and histological methods were used to evaluate photodynamic therapy (PDT)-induced hemorrhagic necrosis in the murine M1 tumor within 72 h of treatment of male DBA/2 mice. The effects of three photosensitizing drugs were investigated: Photofrin (n = 4), Zn (II) phthalocyanine (n ...

journal_title：Photochemistry and photobiology

authors： Winsborrow BG,Grondey H,Savoie H,Fyfe CA,Dolphin D

更新日期：1997-12-01 00:00:00

abstract：:Photoprotective formulations containing substances with antioxidant properties in combination have been used as a strategy for the improvement of photoaged skin conditions. However, there is a lack of studies evaluating the clinical efficacy of these substances in young women with signs of photoaging. Thus, the object...

journal_title：Photochemistry and photobiology

authors： Fossa Shirata MM,Maia Campos PMBG

更新日期：2021-02-02 00:00:00

abstract：:Dark-grown leaves of maize (Zea mays), wheat (Triticum aestivum), wild-type pea (Pisum sativum) and its light-independent photomorphogenesis mutant (lip1) have different proportions of protochlorophyllide (Pchlide) forms as revealed by low-temperature fluorescence emission spectra. Four discrete spectral forms of Pchl...

journal_title：Photochemistry and photobiology

authors： Myśliwa-Kurdziel B,Amirjani MR,Strzałka K,Sundqvist C

更新日期：2003-08-01 00:00:00

abstract：:The maximum erythemal dose rate (EDRmax ) at the Earth's surface tends to occur at local noon. However, clouds can make the timing of EDRmax significantly away from local noon. In fact, EDRmax and its time of occurrence depend mainly on the solar zenith angle at noon (SZAn ), site's altitude, the total ozone column (T...

journal_title：Photochemistry and photobiology

authors： Silva AA,Yamamoto ALC,Corrêa MP

更新日期：2019-05-01 00:00:00

abstract：:We report the synthesis of twelve indole derivatives bearing nitro or amide groups via Fischer indole methodology followed by reduction/acetylation and amidation reactions. After thorough characterization, these indoles were subjected to a number of studies in order to evaluate their bioactive potential as photosynthe...

journal_title：Photochemistry and photobiology

authors： de Souza JM,Fazolo BR,Lacerda JWF,Moura MS,Dos Santos ACR,de Vasconcelos LG,de Sousa Junior PT,Dall'Oglio EL,Ali A,Sampaio OM,Vieira LCC

更新日期：2020-11-01 00:00:00

abstract：:Plastoglobules are lipoprotein particles contained in chloroplasts and other plastids. They have long been regarded as lipid storage droplets. New results now indicate that plastoglobules actively participate in prenylquinone and other metabolic pathways. Structural work shows physical attachment of plastoglobules to ...

journal_title：Photochemistry and photobiology

authors： Bréhélin C,Kessler F

更新日期：2008-11-01 00:00:00

abstract：:The photodynamic therapy (PDT) activity of the bis(dimethylthexylsiloxy)silicon 2,3-naphthalocyanine (SiNc 8) was evaluated against the EMT-6 tumor implanted intradermally in BALB/c mice. The SiNc 8 was formulated in aqueous emulsions based on Cremophor EL or Solutol HS 15. The formulation was shown to affect plasma c...

journal_title：Photochemistry and photobiology

authors： Brasseur N,Ouellet R,Lewis K,Potter WR,van Lier JE

更新日期：1995-12-01 00:00:00

abstract：:Chronic exposure of the gray, short-tailed oppossum, Monodelphis domestica to ultraviolet radiation (UVR) induces mesenchymal tumors of the cornea. High molecular weight DNA samples from 6 UVR-induced corneal tumors were assayed for their ability to transform NIH 3T3 cells to tumorigenicity. NIH 3T3 cells transfected ...

journal_title：Photochemistry and photobiology

authors： Sabourin CL,Freeman AG,Kusewitt DF,Ley RD

更新日期：1992-03-01 00:00:00

abstract：:An ongoing study in our laboratories is to examine the relationship of DNA repair defects to human cancer. Our underlying hypothesis has been that human tumors may arise that lack interesting DNA repair pathways if these pathways are important in preventing cancer. In this study, we found that the UV-irradiated adenov...

journal_title：Photochemistry and photobiology

authors： Day RS 3rd,Rasouli-Nia A,Meservy J,Lari SU,Dobler K,Tsunoda S,Miyakoshi J,Takebe H,Murray D

更新日期：1999-08-01 00:00:00

abstract：:This study assessed the effects of photobiomodulation (PBM) to cells previously exposed to lipopolysaccharides (LPS). Human gingival fibroblasts (HGF) and epithelial cells (HaCaT) were seeded in wells of 24-well plates containing complete culture medium (DMEM). After 24 h, the DMEM was replaced by serum-free DMEM, and...

journal_title：Photochemistry and photobiology

authors： Pansani TN,Basso FG,Soares DG,Turrioni APDS,Hebling J,de Souza Costa CA

更新日期：2018-05-01 00:00:00

abstract：:Time-resolved singlet oxygen, O(2)(a(1)Delta(g)), phosphorescence experiments have been performed in single cells upon pulsed laser irradiation of a photosensitizer incorporated into the cell. Data recorded as a function of the partial pressure of ambient oxygen to which the cell is exposed reflect apparent values for...

journal_title：Photochemistry and photobiology

authors： Hatz S,Poulsen L,Ogilby PR

更新日期：2008-09-01 00:00:00

abstract：:Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wav...

journal_title：Photochemistry and photobiology

authors： Kessel D,Smith KM,Pandey RK,Shiau FY,Henderson B

更新日期：1993-08-01 00:00:00

abstract：:δ-Aminolevulinic acid (ALA)-induced porphyrin accumulation is widely used in the treatment of cancer, as photodynamic therapy. To clarify the mechanisms of the tumor-preferential accumulation of protoporphyrin, we examined the effect of the expression of heme-biosynthetic and -degradative enzymes on the ALA-induced ac...

journal_title：Photochemistry and photobiology

authors： Ohgari Y,Miyata Y,Miyagi T,Gotoh S,Ohta T,Kataoka T,Furuyama K,Taketani S

更新日期：2011-09-01 00:00:00

abstract：:Photolysis of ester 1 in argon-saturated methanol and acetonitrile does not produce any product, whereas irradiation of 1 in oxygen-saturated methanol yields peroxide 2. Laser flash photolysis studies demonstrate that 1 undergoes intramolecular H atom abstraction to form biradical 3 (λmax ~340 nm), which intersystem c...

journal_title：Photochemistry and photobiology

authors： Das A,Lao EA,Gudmundsdottir AD

更新日期：2016-05-01 00:00:00

abstract：:The classic method of photometric curves for photosensitivity determination has been extended to the case of photoreversible reactions and applied to the octopus rhodopsin --> acid metarhodopsin photoreaction. In such cases, measurements at one irradiation wavelength yield the sum of the photosensitivities of the forw...

journal_title：Photochemistry and photobiology

authors： Dixon SF,Cooper A

更新日期：1987-07-01 00:00:00