Abstract:
:Tricyclic antidepressants have notable cardiac side effects, and this issue has become important due to the recent reports of increased cardiovascular mortality in patients with depression and anxiety. Several previous studies indicate that serotonin reuptake inhibitors (SRIs) do not appear to have such adverse effects. Apart from the effects of these drugs on routine 12-lead ECG, the effects on beat-to-beat heart rate (HR) and QT interval time series provide more information on the side effects related to cardiac autonomic function. In this study, we evaluated the effects of two antidepressants, nortriptyline (n=13), a tricyclic, and paroxetine (n=16), an SRI inhibitor, on HR variability in patients with panic disorder, using a measure of chaos, the largest Lyapunov exponent (LLE) using pre- and posttreatment HR time series. Our results show that nortriptyline is associated with a decrease in LLE of high frequency (HF: 0.15-0.5 Hz) filtered series, which is most likely due to its anticholinergic effect, while paroxetine had no such effect. Paroxetine significantly decreased sympathovagal ratios as measured by a decrease in LLE of LF/HF. These results suggest that paroxetine appears to be safer in regards to cardiovascular effects compared to nortriptyline in this group of patients.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Yeragani VK,Rao Rdoi
10.1016/s0022-3999(03)00023-0subject
Has Abstractpub_date
2003-12-01 00:00:00pages
507-13issue
6eissn
0022-3999issn
1879-1360pii
S0022399903000230journal_volume
55pub_type
杂志文章abstract:OBJECTIVES:Functional somatic syndromes are common and disabling conditions that all include chronic pain, and which may be related to central nervous system sensitisation. Here, we address the concept of central sensitisation as a physiological basis for the functional somatic syndromes. METHODS:A narrative review of...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychores.2015.01.003
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To test age- and sex-specific associations between adverse life events and functional bodily symptoms (FBS) in the general population. METHODS:In a population-based cohort, 964 participants (mean age 55 years SD 11, 48% male) completed two measurements waves of the present study. Lifetime exposure to 12 adve...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2015.05.013
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:It has been theorized that conversion disorder is the result of emotion that cannot be experienced consciously as feeling states or put into words (i.e., alexithymia), but there is little confirming empirical evidence. We sought to characterize subjects with conversion disorder compared to subjects with a di...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2013.06.005
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:The multi-wave longitudinal study was to explore the underlying mechanisms between sleep disturbance and depressive symptoms for up to 9.5 months among student nurses and to examine whether emotional exhaustion and sleep-related worry could be the mediators. METHODS:856 student nurses aged 15-24 years (mean ...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2019.109870
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:There are many similarities between chronic fatigue syndrome (CFS), the somatoform disorders and problems otherwise known as "medically unexplained symptoms." There is some evidence to suggest that a combination of inadequate parenting and early illness experience may predispose the individual to develop medi...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(02)00458-0
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To compare salivary cortisol levels and maternal anxiety (general and pregnancy-specific) in the early and late second trimester of pregnancy between women who developed preeclampsia (PE) and women who remained normotensive. DESIGN:Nested case-referent study. In a prospectively studied cohort of 250 pregnant...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(00)00208-7
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The transplanted organ is a key element of the recipient's daily life. But its representations are neither spontaneously expressed by patients, nor taken into account by transplantation professionals. Our objective was to assess specifically the transplanted organ representations in liver transplant recipient...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2012.07.012
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The demanding behavioral changes for weight control to manage diabetes might contribute to lower quality of life (QOL). This research examines whether the demands of diet and exercise contribute to lower QOL among persons with diabetes. METHODS:Data were from the Behavioral Risk Factor Surveillance System (B...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2005.06.062
更新日期:2005-12-01 00:00:00
abstract::The aim of the investigation was to study the prevalence of current and past psychiatric morbidity and psychosocial problems in HIV seropositive (HIV +ve) asymptomatic women. A cross-sectional controlled study including 57 HIV +ve women belonging to CDC group II and III (43 intravenous drug users and 14 non-IVDUs hete...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(93)90097-y
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:This article analyzes the psychometric and structural properties of the Brief Symptoms Inventory 18 in a sample of patients with temporomandibular disorders (TMDs), given the convenience of a brief evaluation of distress in these patients. METHODS:Confirmatory factor analysis was carried out in a sample of 1...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2005.10.013
更新日期:2006-04-01 00:00:00
abstract::A decreased sensitivity to painful stimuli and high scores for alexithymia and depression have been observed in patients with eating disorders. We investigated the relationship between these factors in 22 patients with anorexia nervosa, 18 patients with bulimia nervosa, and 32 healthy subjects. Alexithymia was assesse...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(96)00088-8
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:This article addresses three reliability issues that are problematic in the construction of scales intended for use in psychosomatic research, illustrates how these problems may lead to errors, and suggests solutions. METHODS:We used psychometric results and present five computational studies. The first, thi...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychores.2010.11.002
更新日期:2011-06-01 00:00:00
abstract::A total of 42 chronic temporomandibular joint pain patients completed behavioral therapy for their pain. The role of clinical, sociodemographic, and psychosocial factors was examined in relation to treatment outcome (immediately following treatment and at 2-yr follow-up). Psychosocial factors were better predictors of...
journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0022-3999(84)90077-1
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:This study aimed for a comprehensive evaluation of major depressive disorder (MDD) in stable coronary heart disease (CHD) patients, excluding all other potential psychiatric comorbidities, and including associations with cardiac biomarkers such as C-reactive protein (CRP), troponin T (TnT), and amino-terminal...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2008.09.010
更新日期:2009-03-01 00:00:00
abstract::The past 25 yrs has seen the evolution from concepts based on specificity of stimulus, mediating pathway and target organ response to concepts embodying the multifactorical nature of psychosomatic disorders in which various combinations of causal factors operate within a particular disorder which is therefore heteroge...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(83)90093-4
更新日期:1983-01-01 00:00:00
abstract::Governmental agencies do not systematically investigate the presence of daytime sleepiness as a determinant of driving accidents. We surveyed automobile drivers traveling on summer vacations and driving long distances on a European highway. We evaluated their subjective daytime sleepiness while driving and any sleep d...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(96)00127-4
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:We explored the extent to which changes in emotional states following exposure to images of idealized bodies predict unhealthy body change attitudes and behaviors in women and men, and whether particular psychological traits mediate these effects. METHOD:One hundred thirty-three women and 93 men were assesse...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2006.11.001
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Functional memory disorder (FMD) is an acquired nonorganic condition characterized by significant deficits of memory and concentration that occur in daily living and are thought to be caused by psychosocial burden and distress. FMD is an important differential diagnosis to organic mild cognitive impairment. A...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2009.04.005
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Mindfulness may diminish effects of adversities on psychological well-being in medical patients, but studies are scarce, especially in patients with rheumatoid arthritis (RA). The purpose was to examine the prospective moderating effect of mindfulness regarding psychological distress associated with disease a...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2014.08.004
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To examine the psychometric properties of the Type D Scale (DS14) in mainland China. METHODS:One hundred and seventy-eight coronary heart disease (CHD) patients and 376 healthy controls were recruited. They completed the Chinese version of the DS14, the Zung Self-Rating Depression Scale, the Positive Affect ...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2008.06.009
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:This study examines sociocultural influences affecting both body image and body change methods in adolescent boys. METHODS:Twenty boys in grade 7 (aged 12-13) and twenty boys in grade 9 (aged 14-15) were individually interviewed. The influence of parents, siblings, friends and the media on both body image an...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(00)00159-8
更新日期:2000-09-01 00:00:00
abstract::Substantial numbers of patients suffer from chronic back pain without demonstrating identifiable organic pathology of the spine. Since standardized methods of assessing psychological disturbances (e.g. MMPI) in such patients often provoke hostility and resentment, a questionnaire (BPCS) was developed which employs ver...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(86)90002-4
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:This study evaluates the Brief Illness Perception Questionnaire (Brief IPQ), a nine-item scale designed to rapidly assess the cognitive and emotional representations of illness. METHODS:We assessed the test-retest reliability of the scale in 132 renal outpatients. We assessed concurrent validity by comparing...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2005.10.020
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Optimism is thought to be associated with long-term favourable outcomes for patients undergoing coronary artery bypass graft (CABG) surgery. Our objective was to examine the association between optimism and post-operative pain and physical symptoms in CABG patients. METHODS:We assessed optimism pre-operative...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2014.07.018
更新日期:2014-10-01 00:00:00
abstract::Taking into account neuroticism and lifestyle variables (smoking and alcohol consumption), cardiovascular and psychological reactions to stressful films were studied in four groups of subjects selected on self-reported levels of recent stressor load and symptom complaints (low-load/low-symptoms: low-load/high-symptoms...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(95)00516-1
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVES:Glandular fever is associated with an approximate fivefold increase in fatigue at 6 months. Reduced levels of fitness and illness beliefs may be important predictors of fatigue following glandular fever. We therefore developed a brief psycho-educational intervention aimed at improving recovery from infectiou...
journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0022-3999(03)00370-2
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:Research suggests that following a myocardial infarction (MI), women under the age of 60 have more elevated depressive symptoms and adverse outcomes than similarly aged men. Identifying risk factors that contribute to gender differences in depressive symptoms among this group may be critical to the developme...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2019.109782
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:Mental fatigability refers to the failure to sustain participation in tasks requiring mental effort. Older adults with vascular risk are at particular risk for experiencing mental fatigability. The present study (1) tested a new way of measuring objective mental fatigability by examining its association with...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2014.04.001
更新日期:2014-06-01 00:00:00
abstract::Chronic fatigue syndrome (CFS) is a poorly understood condition. Possible etiological factors include infectious agents, psychiatric disorders, and personality characteristics. We examined personality dimensions in 30 nondepressed patients with CFS, 20 patients with major depressive disorder (MDD), and 15 healthy cont...
journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章
doi:10.1016/s0022-3999(98)00120-2
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Comorbidity studies have shown that depression and somatization (multiple somatoform symptoms) often overlap. Therefore it has been suggested to classify at least some patients with somatization syndromes under the category of depressive disorders. We wanted to investigate whether psychobiological investigat...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychores.2010.02.001
更新日期:2010-05-01 00:00:00