A randomised controlled trial of a psycho-educational intervention to aid recovery in infectious mononucleosis.


OBJECTIVES:Glandular fever is associated with an approximate fivefold increase in fatigue at 6 months. Reduced levels of fitness and illness beliefs may be important predictors of fatigue following glandular fever. We therefore developed a brief psycho-educational intervention aimed at improving recovery from infectious mononucleosis, and piloted a randomised controlled trial to evaluate the intervention. METHODS:We performed a randomised-controlled trial in primary health care in Southeast London and Kent. Sixty-nine patients aged between 16 and 45 years who were diagnosed, serologically and clinically, with acute infectious mononucleosis between December 1999 and December 2000 were randomised. The control group received a standardised fact-sheet about infectious mononucleosis, which gave no advice on rehabilitation. Patients who were randomised to the intervention received an individual treatment session, two follow-up telephone calls, and an information booklet. Fatigue score 6 months after the onset of infectious mononucleosis was the main outcome measure. RESULTS:Sixty-nine out of 139 patients referred were recruited and randomised. Eighty-seven percent of those recruited completed the Fatigue Questionnaire at 6 months. The intervention was acceptable to all who received it. There were fewer fatigue cases in the intervention group than the control group at 6 months follow-up (odds ratio 0.31, 95% confidence interval 0.09-0.91). CONCLUSIONS:A brief intervention at the diagnosis of infectious mononucleosis is acceptable, and may help prevent the development of chronic fatigue. Definitive randomised controlled trials are required to test the intervention.


J Psychosom Res


Candy B,Chalder T,Cleare AJ,Wessely S,Hotopf M




Has Abstract


2004-07-01 00:00:00














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    abstract:OBJECTIVE:Psychosocial stress is associated with substantial morbidity and mortality. Accordingly, there is a growing interest in biomarkers that indicate whether individuals show adaptive (i.e., stress-buffering and health-promoting) or maladaptive (i.e., stress-escalating and health-impairing) stress reactions in soc...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Lischke A,Jacksteit R,Mau-Moeller A,Pahnke R,Hamm AO,Weippert M

    更新日期:2018-03-01 00:00:00

  • Unfairness and the social gradient of metabolic syndrome in the Whitehall II Study.

    abstract:OBJECTIVES:Little work has investigated the relationship between unfairness and risk factors for heart disease. We examine the role of unfairness in predicting the metabolic syndrome and explaining the social gradient of the metabolic syndrome. METHODS:The design is a prospective study with an average follow-up of 5.8...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: De Vogli R,Brunner E,Marmot MG

    更新日期:2007-10-01 00:00:00

  • Life event stress and chronic difficulties in duodenal ulcer: a case control study.

    abstract::In a sample of consecutive ulcer (DU) patients and age, sex and social class matched normal controls, the prevalence of antecedent stressful life events in the two samples was similar. Antecedent chronic difficulties often lasting years were however significantly more common in the ulcer patients. Duodenal ulcer was m...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Gilligan I,Fung L,Piper DW,Tennant C

    更新日期:1987-01-01 00:00:00

  • Sense of life worth living (ikigai) and incident functional disability in elderly Japanese: The Tsurugaya Project.

    abstract:OBJECTIVE:To test the hypothesis that elderly persons who feel ikigai (a sense of life worth living) have a lower risk of incident functional disability than those who do not. Recent studies have suggested that ikigai impacts on mortality. However, its impact upon disability is unknown. The aim of the present study was...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Mori K,Kaiho Y,Tomata Y,Narita M,Tanji F,Sugiyama K,Sugawara Y,Tsuji I

    更新日期:2017-04-01 00:00:00

  • Twenty-five years with the 20-item Toronto Alexithymia Scale.

    abstract:OBJECTIVE:Twenty-five years ago, this journal published two articles reporting the development and initial validation of the 20-Item Toronto Alexithymia Scale (TAS-20). Since then the literature on alexithymia has burgeoned with the vast majority of this research using the TAS-20, including multiple language translatio...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章,评审


    authors: Bagby RM,Parker JDA,Taylor GJ

    更新日期:2020-01-23 00:00:00

  • The assessment of alexithymia: a critical review of the literature and a psychometric study of the Toronto Alexithymia Scale-20.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章,评审


    authors: Kooiman CG,Spinhoven P,Trijsburg RW

    更新日期:2002-12-01 00:00:00

  • Do illness perceptions predict health outcomes in primary care patients? A 2-year follow-up study.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Frostholm L,Oernboel E,Christensen KS,Toft T,Olesen F,Weinman J,Fink P

    更新日期:2007-02-01 00:00:00

  • Symptoms of anxiety and depression in patients undergoing chronic haemodialysis.

    abstract::Symptoms of anxiety and depression in a sample of 82 patients undergoing chronic haemodialysis were assessed using the Symptoms of Anxiety and Depression Scale. Mean anxiety and depression scores, were found to be significantly higher than those of normal subjects. The frequency of personal disturbance and personal il...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Livesley WJ

    更新日期:1982-01-01 00:00:00

  • Risk factors for impaired health status differ in women and men treated with percutaneous coronary intervention in the drug-eluting stent era.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Pedersen SS,Ong AT,Lemos PA,Erdman RA,Serruys PW,van Domburg RT

    更新日期:2006-07-01 00:00:00

  • Statistical methods in randomised controlled trials for delirium.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Farewell D,Tahir TA,Bisson J

    更新日期:2012-09-01 00:00:00

  • Predictors of long term outcome following a bladder re-training programme.

    abstract::A total of fifty-three female patients suffering from urinary urgency and urge incontinence completed a bladder re-training programme which comprised behavioural and biofeedback treatment components. The psychological status of patients prior to treatment and at eighteen-month follow-up was compared. The role of clini...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Oldenburg B,Millard RJ

    更新日期:1986-01-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: McQuaid EL,Fritz GK,Nassau JH,Lilly MK,Mansell A,Klein RB

    更新日期:2000-10-01 00:00:00

  • Age is strongly associated with alexithymia in the general population.

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    pub_type: 杂志文章


    authors: Mattila AK,Salminen JK,Nummi T,Joukamaa M

    更新日期:2006-11-01 00:00:00

  • Diabetes, prediabetes, and suicide deaths in a Japanese working population.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Fukunaga A,Hu H,Inoue Y,Nakagawa T,Honda T,Yamamoto S,Miyamoto T,Okazaki H,Shimizu M,Eguchi M,Kochi T,Yamamoto M,Ogasawara T,Sasaki N,Uehara A,Imai T,Nishihara A,Hori A,Nagahama S,Tomita K,Konishi M,Kabe I,Miz

    更新日期:2020-11-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Abouzeid M,Kelsall HL,Forbes AB,Sim MR,Creamer MC

    更新日期:2012-01-01 00:00:00

  • Checklists for measuring response style in hypertensives.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Cumes-Rayner DP,Price J

    更新日期:1989-01-01 00:00:00

  • A UK based review of recommendations regarding the management of chronic fatigue syndrome.

    abstract:OBJECTIVES:Chronic fatigue syndrome (CFS) is a controversial illness, with apparent disagreements between medical authorities and patient support organisations regarding safe and effective treatments. The aim of this study was to measure the extent of different views regarding treatments, comparing patient support orga...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Mallet M,King E,White PD

    更新日期:2016-09-01 00:00:00

  • Autonomic reactivity during reading of a somatic distress script in patients with somatic symptom disorder.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Huang WL,Liao SC,Tu YK,Yang CCH,Kuo TBJ,Gau SS

    更新日期:2019-08-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Muth ER,Stern RM,Thayer JF,Koch KL

    更新日期:1996-05-01 00:00:00

  • Psychobiological differences between depression and somatization.

    abstract:BACKGROUND:Comorbidity studies have shown that depression and somatization (multiple somatoform symptoms) often overlap. Therefore it has been suggested to classify at least some patients with somatization syndromes under the category of depressive disorders. We wanted to investigate whether psychobiological investigat...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章,评审


    authors: Rief W,Hennings A,Riemer S,Euteneuer F

    更新日期:2010-05-01 00:00:00

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    abstract:OBJECTIVE:To determine the associations between social network size and subsequent long-term health behaviour patterns, as indicated by alcohol use, smoking, and physical activity. METHODS:Repeat data from up to six surveys over a 15- or 20-year follow-up were drawn from the Finnish Public Sector study (Raisio-Turku c...

    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章,多中心研究


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    更新日期:2017-08-01 00:00:00

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    journal_title:Journal of psychosomatic research

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    authors: Weihs KL,Simmens SJ,Mizrahi J,Enright TM,Hunt ME,Siegel RS

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Nyklíček I,Hoogwegt F,Westgeest T

    更新日期:2015-02-01 00:00:00

  • The effects of photic driving on mood states.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: von Gizycki H,Jean-Louis G,Snyder M,Zizi F,Green H,Giuliano V,Spielman A,Taub H

    更新日期:1998-05-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Ell K,Nishimoto R,Mantell J,Hamovitch M

    更新日期:1988-01-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2002-07-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Derogatis LR

    更新日期:1986-01-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Ohayon MM,Guilleminault C,Priest RG,Zulley J,Smirne S

    更新日期:2000-06-01 00:00:00

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    journal_title:Journal of psychosomatic research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Taylor CB,Houston-Miller N,Ahn DK,Haskell W,DeBusk RF

    更新日期:1986-01-01 00:00:00

  • The variability of type I hypersensitivity reactions: the importance of mood.

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    journal_title:Journal of psychosomatic research

    pub_type: 杂志文章


    authors: Laidlaw TM,Booth RJ,Large RG

    更新日期:1994-01-01 00:00:00