Abstract：
BACKGROUND:Comorbidity studies have shown that depression and somatization (multiple somatoform symptoms) often overlap. Therefore it has been suggested to classify at least some patients with somatization syndromes under the category of depressive disorders. We wanted to investigate whether psychobiological investigations confirm the lumping of somatization and depression, or whether psychobiological pathways favor distinguishing these disorders. METHOD:An overview is presented summarizing psychobiological studies including patients with depression and/or somatization-associated syndromes. We focus on the following topics: heritability, polymorphisms in special candidate genes, immune activation, hypothalamic-pituitary-adrenal (HPA) axis reactivity, serotonergic pathways, monoamino acids, and fatty acid concentrations. RESULTS:Immunological activation seems to be associated with specific features of somatoform disorders, namely, sickness behavior and pain thresholds. Genetic factors can also contribute to somatic complaints, e.g., via serotonergic pathways, HPA-axis response, immune activation, and other biological systems that contribute to the self-description of not being healthy. Some results indicate that psychobiological aspects of depression and somatization overlap in part (e.g., the relevance of serotonergic pathways), but there is clearly more evidence for discrepancies of psychobiological pathways in depression and somatization (e.g., the relevance of proinflammatory immune processes; HPA-axis activity; monoamino acid availability; omega-3-concentration; the role of triallelic subtypes of 5-HTTLPR). CONCLUSION:Many psychobiological pathways act differently in depression and somatization. These differences in psychobiology favor the distinction of these syndromes in classification approaches.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Rief W,Hennings A,Riemer S,Euteneuer Fdoi
10.1016/j.jpsychores.2010.02.001subject
Has Abstractpub_date
2010-05-01 00:00:00pages
495-502issue
5eissn
0022-3999issn
1879-1360pii
S0022-3999(10)00072-3journal_volume
68pub_type
杂志文章,评审abstract：OBJECTIVE:The question addressed here is: Can a discrete sleep disordered breathing (SDB) play a role in the insomnia complaint of postmenopausal chronic insomniacs? To respond to the query, two groups of individuals derived from a cohort of postmenopausal chronic insomniacs recruited mostly from the community were enl...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0022-3999(02)00463-4
更新日期：2002-07-01 00:00:00
abstract：:The purpose of the present study was to assess body perception in eating disorders and its meaning in therapy. A total of 44 patients, 25 bulimia nervosa and 19 anorexia nervosa, admitted at a specialized in-patient treatment center participated in the present study. Body size estimation procedures (video-distortion a...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(99)00027-6
更新日期：1999-11-01 00:00:00
abstract：:The purpose of this study was to conduct a meta-analysis [16] of research comparing the effects on physical adaptation of two cognitive strategies for coping with stressors: attention and rejection. Attention refers to focusing attention on the stressor and/or on one's rejection to it; rejection refers to focusing att...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(82)90061-7
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people. METHODS:At the baseline of the ESTHER study (2000-2002), 9953 participants completed...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.01.019
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:Self-reported asthma symptoms correlate only modestly with measures of underlying pathophysiological mechanisms. In this study, we investigated the role of fear of symptoms and perceived control on respiratory symptom perception in patients with asthma. METHODS:Patients with intermittent to moderate persiste...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2011.04.005
更新日期：2011-09-01 00:00:00
abstract：:Despite the widespread use of life event inventories, relatively little research has been conducted evaluating whether recall techniques can reduce reporting errors. This study evaluated whether memory aids would reduce errors in reports of life events and explored subjects' explanations for why they had given inconsi...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0022-3999(90)90050-e
更新日期：1990-01-01 00:00:00
abstract：:Several studies have reported raised levels of psychopathology based on self-rating scales in patients with spasmodic torticollis. Recent publications have also proposed that psychopathology, especially symptoms of depression, might be a reaction to dystonia or constitute a nonspecific reaction pattern. To determine t...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00229-8
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVE:In this cross-sectional pilot study of couples in whom the man was diagnosed with prostate cancer or the woman with breast cancer, the purpose was to identify and compare the variables that characterize couples where both spouses are in high psychological distress with couples where the psychological distress...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(03)00502-6
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVES:Little work has investigated the relationship between unfairness and risk factors for heart disease. We examine the role of unfairness in predicting the metabolic syndrome and explaining the social gradient of the metabolic syndrome. METHODS:The design is a prospective study with an average follow-up of 5.8...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2007.04.006
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:Two studies were conducted to assess the construct validity of the Symptom Interpretation Questionnaire (SIQ) with particular attention to its relationship to social desirability, daily symptom, mood, hassles reports, and personality. METHODS:Participants completed a battery of self-report measures collected...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2006.07.006
更新日期：2006-12-01 00:00:00
abstract：:To evaluate the relationship between stressful life events and the onset of secondary amenorrhoea Paykel's semi-structured interview for Recent Life Events was administered to patients affected by secondary amenorrhea and also to healthy volunteers. The number, quality, and objective negative impact of life events wer...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(94)90059-0
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:Recent evidence shows that bipolar disorder might be associated with a purinergic system dysfunction. This study aimed at (i) testing the association between bipolar disorder and uric acid serum levels, and (ii) clarifying whether this relationship is mediated by metabolic syndrome and other relevant metaboli...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2016.03.014
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:The aim of this preliminary study was to characterize the levels of plasma adrenocorticotropic hormone (ACTH) and cortisol in adult patients with Asperger syndrome (AS). METHODS:Twenty medication-free individuals with high-functioning AS were recruited from a clinic specialized in autism spectrum disorders. ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2004.12.004
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVES:To compare the frequency of anxiety/depressive symptoms and use of anxiolytic-hypnotics/antidepressants in smokers with and without COPD and to identify characteristics associated with having unmedicated symptoms. METHODS:Cross-sectional analysis of ambulatory, current/former smokers ≥10 pack years enrolled...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.01.002
更新日期：2019-03-01 00:00:00
abstract：:A group of 104 patients with inflammatory bowel disease (IBD) was followed longitudinally for 6 months. While anxiety and depression scores were influenced over time by changes in the level of disease activity, there was no significant change in alexithymia scores. The findings support the contention that alexithymia ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(96)00221-8
更新日期：1996-12-01 00:00:00
abstract：OBJECTIVE:Cardiac patients with psychological distress have a poorer prognosis than patients without distress; which may in part reflect differences in treatment. We quantified variation in coronary angiography and revascularisation procedures according to psychological distress among patients admitted with incident ac...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.109794
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:In 2008, the Board of the European Association of Consultation-Liaison Psychiatry and Psychosomatics (EACLPP) and the Academy of Psychosomatic Medicine (APM) Council commissioned the creation of a task force to study consensus-based summaries of core roles, scope of clinical practice, and basic competencies f...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2011.02.008
更新日期：2011-05-01 00:00:00
abstract：:Eating disorders in diabetes mellitus may be associated with serious diabetic complications. This study examines the prevalence of complications and the usefulness of the Eating Attitudes Test (EAT) in screening for eating disorders in a group of insulin-dependent diabetic women. Coping strategies for dealing with dia...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(95)00534-x
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVE:Given the high rate of psychiatric comorbidity with chronic fatigue syndrome (CFS), we considered two possible correlates of anxiety and depression: lack of illness legitimization and beliefs about limiting physical activity. METHOD:A total of 105 people diagnosed with CFS reported on their experiences with ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(02)00318-5
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:An interaction between the endothelin-1 gene (EDN1), blood pressure (BP) and social determinants has been previously found. Using a well-characterized cohort of participants, the impact of associations between genetic factors and job strain on BP was evaluated. METHODS:A cross-sectional analysis of five poly...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2011.01.003
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:In the operant conditioning of hypertension hypothesis, it is assumed that the frequently found diminished sensitivity to painful stimuli in hypertensives can be generalized to sensitivity to other stressors, including psychological stressors. The validity of this assumption is examined in the present study. ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(01)00194-5
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:To determine the relative contribution of demographic variables, objective testing and psychological factors in explaining the variance in dizziness severity and handicap. METHODS:One-hundred and eighty-five consecutive patients on the waiting list to attend a diagnostic appointment in a tertiary neuro-otolo...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2020.109969
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that elderly persons who feel ikigai (a sense of life worth living) have a lower risk of incident functional disability than those who do not. Recent studies have suggested that ikigai impacts on mortality. However, its impact upon disability is unknown. The aim of the present study was...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2017.02.013
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:This study aimed to test relations of physical self-concept and self-efficacy with voluntary physical activity in preadolescents enrolled in an after-school physical activity program. METHODS:Participants in the 2003 (n=41) and 2005 (n=84) versions of the Youth Fit For Life protocol and the control group (n=...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2006.04.009
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVES:Chronic fatigue syndrome (CFS) is a controversial illness, with apparent disagreements between medical authorities and patient support organisations regarding safe and effective treatments. The aim of this study was to measure the extent of different views regarding treatments, comparing patient support orga...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2016.07.008
更新日期：2016-09-01 00:00:00
abstract：:Recent theoretical approaches to the etiology of eating disorders and body image disturbances have begun to focus on multifactorial models. In the current study, the Tripartite Influence model was examined in a large sample of college females (ages 18-22). This model proposes that three primary core sources of influen...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(02)00499-3
更新日期：2002-11-01 00:00:00
abstract：:The relation of stress and family environment to symptom severity in children with atopic dermatitis (AD) was examined. Forty-four children with severe AD and their families completed questionnaires measuring life events, chronic everyday problems and family environment. Measures of symptom severity were collected dur...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(87)90016-x
更新日期：1987-01-01 00:00:00
abstract：:The article describes a longitudinal study testing the hypothesis that everyday stress can aggravate angina pectoris (AP). Every weekend for 1 year, 42 patients with coronary heart disease filled out a questionnaire on perceived stress for the preceding week. They also rated AP symptoms, again for the previous week. W...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00054-8
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:No previous studies have investigated the psychiatric characteristics of patients with postherpetic neuralgia (PHN). Similarly, no studies have been performed on patients with different chronic somatic symptoms due to a defined medical disease to compare the characteristics of psychiatric morbidity associated...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(99)00076-8
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:Body dysmorphic disorder (BDD) is characterized by an excessive preoccupation with an imagined or minor appearance flaw. Many aspects of BDD remain unknown, such as rates of treatment utilization, types of treatment sought, and barriers to treatment. The present study sought to examine rates and patterns of ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.10.002
更新日期：2011-03-01 00:00:00
