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Association between major depressive disorder and C-reactive protein levels in stable coronary heart disease patients.

Abstract：

OBJECTIVE:This study aimed for a comprehensive evaluation of major depressive disorder (MDD) in stable coronary heart disease (CHD) patients, excluding all other potential psychiatric comorbidities, and including associations with cardiac biomarkers such as C-reactive protein (CRP), troponin T (TnT), and amino-terminal pro-B-type brain natriuretic peptide (NT-proBNP). METHODS:Cross-sectional study of a consecutive series of 72 stable CHD outpatients (n=30 with MDD, n=42 with no psychiatric disorder). Psychiatric diagnoses were established by using the Structured Clinical Interview for DSM-IV (SCID), and psychiatric assessment was performed on Axis I, Axis III, Axis IV, and Axis V. Regression analyses were performed including CRP, TnT, and NT-proBNP as dependent variables, and MDD, demographics, and comorbid medical conditions as independent variables. RESULTS:Stepwise multiple regression analyses showed a significant association between MDD and CRP (beta=0.262, P=.02), excluding all other demographic and medical variables from the models, except age (beta=0.266, P=.02). In addition, the results described a significant relationship between type II diabetes mellitus and TnT (beta=0.267, P=.02), and age and NT-proBNP levels (beta=0.374, P=.001). CONCLUSION:Major depressive disorder was associated with elevated CRP levels in a consecutive series of stable CHD patients.

journal_name

J Psychosom Res

journal_title

Journal of psychosomatic research

authors

Bankier B,Barajas J,Martinez-Rumayor A,Januzzi JL

doi

10.1016/j.jpsychores.2008.09.010

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

189-94

issue

3

eissn

0022-3999

issn

1879-1360

pii

S0022-3999(08)00435-2

journal_volume

66

pub_type

杂志文章

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