Abstract：
OBJECTIVE:Chronic fatigue syndrome (CFS) is often associated with significant levels of disability. Although fatigue and depression have been found to be independently related to severity of disability, it is not clear how these three factors are mutually related. The present study sought to address this issue by specifically testing a model of mediation whereby depression was hypothesized to influence relations between fatigue and disability. METHODS:Participants included 90 individuals seeking treatment for CFS at a tertiary care facility. Each provided demographic information and completed standardized measures of depression and fatigue severity, as well as a measure of disability, which assessed difficulties in physical, psychosocial, and independence domains. RESULTS:Analyses indicated that depression and fatigue were positively correlated with one another, as well as all three disability domains. Analyses of mediation indicated that depression completely mediated the relation between fatigue and psychosocial disability and partially mediated the relation between fatigue and the other two disability domains. Indirect effects tests indicated that the inclusion of depression in the statistical models was statistically meaningful. CONCLUSIONS:These results replicate previous findings that fatigue and depression are independently related to disability in those with CFS. A more complex statistical model, however, suggested that depression severity substantially influenced the strength of the relation between fatigue and disability levels across a range of domains, including complete mediation in areas involving psychosocial functioning. These results may aid in clarifying contemporary conceptualizations of CFS and provide guidance in the identification of appropriate treatment targets.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Hadlandsmyth K,Vowles KEdoi
10.1016/j.jpsychores.2008.08.002subject
Has Abstractpub_date
2009-01-01 00:00:00pages
31-5issue
1eissn
0022-3999issn
1879-1360pii
S0022-3999(08)00394-2journal_volume
66pub_type
杂志文章abstract：:The effect of exercise training on quality of life and exercise capacity was studied in 67 patients with mild to moderate chronic heart failure (CHF; age: 65.6+/-8.3 years; left ventricular ejection fraction: 26.5+/-9.6%). Patients were randomly allocated to either a training group or to a control group. After interve...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0022-3999(97)00309-7
更新日期：1998-11-01 00:00:00
abstract：:This cross-sectional study reveals that a significant proportion (35%) of the sampled population of factory workers experienced measurable health problems in the form of anxiety, sleep disturbance, depression, somatic complaints and other clinical indicators of stress. Job stress and social support levels experienced ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(91)90071-u
更新日期：1991-01-01 00:00:00
abstract：:A total of 42 chronic temporomandibular joint pain patients completed behavioral therapy for their pain. The role of clinical, sociodemographic, and psychosocial factors was examined in relation to treatment outcome (immediately following treatment and at 2-yr follow-up). Psychosocial factors were better predictors of...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0022-3999(84)90077-1
更新日期：1984-01-01 00:00:00
abstract：:Few studies have investigated relationships between psychological variables and survival after bone marrow transplantation (BMT). There is some evidence that psychological variables play a role in the course of cancer, and also after BMT. The present study focused on relationships between psychological variables and s...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(98)00003-8
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVE:Individuals with medical conditions are likely to have elevated health anxiety; however, research has not demonstrated how medical status impacts response patterns on health anxiety measures. Measurement bias can undermine the validity of a questionnaire by overestimating or underestimating scores in groups o...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.12.014
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine whether absorption and spirituality predict the placebo response independently of expectancy. METHOD:This was an open study of self-treatment with self-selected Bach flower essences. Participants' expectancy of the effect of flower essences, attitudes to complementary m...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2005.06.073
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:The current study focused on the role of trait mindfulness in asthma-related quality of life (QoL) and asthma control in adolescent asthma patients. Furthermore, potential underlying mechanisms (general and asthma-specific stress) of this relationship were investigated. METHODS:In this cross-sectional study,...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2017.06.014
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:Medically unsubstantiated 'intolerances' to foods, chemicals and environmental toxins are common and are frequently discussed in the media. Idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) is one such condition and is characterized by symptoms that are attributed to exposure...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychores.2012.12.002
更新日期：2013-03-01 00:00:00
abstract：:Although frequently investigated in the general population, the epidemiology of insomnia complaints and their treatment have received little attention in general practice. This study recruited patients > or =15 years of age, consecutively, from 127 general practitioners in France. The physicians collected data from 11...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(98)00079-8
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVE:Rheumatoid arthritis (RA) has been associated with a variety of emotional stressors, but findings remain inconclusive if RA is related to childhood trauma, which is known to have long-lasting negative consequences for physical health decades into adulthood. We investigated the association between childhood tr...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.10.007
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVE:To report sex-specific associations between cigarette smoking and DSM-IV disorders, symptoms, and mental health services use related to depression and anxiety in a nationally representative sample of U.S. adolescents. METHODS:Data on two samples were drawn from the 1999-2004 National Health and Nutrition Exa...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.01.013
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:There are many similarities between chronic fatigue syndrome (CFS), the somatoform disorders and problems otherwise known as "medically unexplained symptoms." There is some evidence to suggest that a combination of inadequate parenting and early illness experience may predispose the individual to develop medi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(02)00458-0
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:Depression, one of the most prevalent and disabling disorders in Europe, is thought to be associated with unhealthy eating styles. As prevalence of depression and eating styles potentially differ across Europe, the current study aimed to investigate in a large, European sample, the associations of history of ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.03.003
更新日期：2018-05-01 00:00:00
abstract：:Some degree of depression affects at least 30% of hospitalized patients with coronary artery disease (CAD), and is associated with increased risks of mortality and continuing depression over at least the first year following hospital discharge. Despite its consequences for prognosis and quality of life, depression is ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/s0022-3999(99)00102-6
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:This study aimed to determine the profile of dementia in a sub-Saharan Africa country and assess its effects on role functioning and quality of life. METHODS:Using a multistage, stratified, clustered sampling of households in the Yoruba-speaking areas of Nigeria, representing 22% of the national population, ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2006.07.016
更新日期：2006-09-01 00:00:00
abstract：:Nature and frequency of somatic complaints, severity of anxiety and depression, and nature of psychiatric symptoms and disorders were evaluated in 81 adequately treated cancer patients, disease-free or with residual disease, using a controlled, prospective follow-up design. Patients were included in the index group (n...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0022-3999(98)00013-0
更新日期：1998-09-01 00:00:00
abstract：:Recent concerns in occupational health have shown a shift in emphasis from the study of diseases with well-established pathology toward the investigation of conditions characterized by a range of nonspecific symptoms. Exposure to potential hazards differing widely in terms of their physical nature or chemical composit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00085-8
更新日期：1997-07-01 00:00:00
abstract：:The pattern of complaints of patients with the hyperventilation syndrome (HVS) was studied on the basis of the Nijmegen HVS Questionnaire (van Doorn, Colla, Folgering). This list was completed by 75 patients with the clinical diagnosis HVS. Non-metric principal components analysis (NMPCA) showed that the structure was...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(85)90042-x
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:Modern health worries (MHW) are concerns about health risks from features of modern life (e.g. additives in food, contaminated water supply, drug resistant bacteria, etc.). We investigated the role of MHW for care seeking for all purposes at the general practitioner (GP) and studied the role of neuroticism, s...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.07.007
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people. METHODS:At the baseline of the ESTHER study (2000-2002), 9953 participants completed...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.01.019
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the association between familial socioeconomic status (SES) and children's sleep problems, and the role of sleep problems as a mediator between familial SES and childhood mental health problems. METHODS:Participants were 5781 11-13 year old children from the Bergen Ch...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.09.008
更新日期：2012-12-01 00:00:00
abstract：:The generalizability of cardiovascular reactivity change scores remains largely unsupported. In previous studies, several factors differed between laboratory and field, making poor lab-to-life correlations difficult to interpret. The present study varied only one parameter between the lab and field: setting. In this s...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00207-9
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVES:Little work has investigated the relationship between unfairness and risk factors for heart disease. We examine the role of unfairness in predicting the metabolic syndrome and explaining the social gradient of the metabolic syndrome. METHODS:The design is a prospective study with an average follow-up of 5.8...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2007.04.006
更新日期：2007-10-01 00:00:00
abstract：:Psychological responses to a diagnosis of breast cancer, assessed three months post operatively, are related to outcome 10 yr after operation. These results confirm the findings previously reported at 5 yr. The need for further study into the nature of the reported psychological response categories and the likely medi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(84)90066-7
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:Although attempted suicide is one of the strongest predictors of completed suicide, few Japanese studies have described psychiatric differences between those who attempt suicide by overdose (OD) and those who use more violent methods (MV). METHODS:A total of 22 consecutively admitted MVs were compared to 78 ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(03)00024-2
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To date, most research on perceived discrimination and cardiovascular disease (CVD) has examined racial discrimination although other forms of discrimination may also impact physical and mental health. The current study investigated the relationship between three forms of discrimination (weight, race, and gen...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2017.07.007
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:Obesity and depression are associated with somatic complaints that may complicate the measurement of depression in obese individuals. The Beck Depression Inventory-II (BDI-II) and the Hamilton Rating Scale for Depression (HRSD) are frequently used to measure depression severity. The BDI-II and HRSD's ability ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2013.08.015
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:Presently, little is known about the characteristics and impact of integrated care programs for patients with psychological comorbidity. The aim was to provide an overview of these integrated care programs and their effectiveness. METHODS:Systematic literature review including papers published between 1995 a...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychores.2015.07.013
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To identify trajectories of cognitive-affective depressive symptoms among acutely hospitalized older patients and whether trajectories are related to prognostic baseline factors and three-month outcomes such as functional decline, falls, unplanned readmissions, and mortality. METHODS:Prospective multicenter ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.03.011
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:To investigate the strength of chronic fatigue syndrome (CFS) patients' negative illness perceptions by comparing illness perceptions and self-reported disability in patients with CFS and rheumatoid arthritis (RA). METHODS:Seventy-four RA patients and 49 CFS patients completed the Illness Perception Question...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(03)00013-8
更新日期：2003-10-01 00:00:00
