Abstract：
OBJECTIVE:Rheumatoid arthritis (RA) has been associated with a variety of emotional stressors, but findings remain inconclusive if RA is related to childhood trauma, which is known to have long-lasting negative consequences for physical health decades into adulthood. We investigated the association between childhood trauma and RA by comparing histories of child abuse and neglect between RA patients and adults from the general population in a cross-sectional case-control study. METHODS:331 patients with definite RA and 662 gender- and age-matched adults from the general population were administered the self-report Childhood Trauma Questionnaire (CTQ) for the assessment of emotional, physical and sexual abuse as well as emotional and physical neglect. RESULTS:Adjusting for gender and current depression, RA patients scored significantly higher in all CTQ subscales apart from sexual abuse and physical neglect than the controls. Adjusted odds ratios for these types of childhood trauma were higher in the RA group than in controls ranging from 2.0 for emotional neglect (95% confidence interval [CI]: 1.4-3.0) to 2.6 for emotional abuse (95% CI: 1.4-4.7). Gender-specific analyses revealed basically the same pattern for women, but not for men. CONCLUSION:Our findings suggest an association between childhood trauma and development of RA, particularly in women. This relationship may be mediated by dysregulations of neuro-endocrine-immune networks, but larger prospective studies are needed to clarify the association between early life stress and the risk for RA in genetically susceptible individuals.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Spitzer C,Wegert S,Wollenhaupt J,Wingenfeld K,Barnow S,Grabe HJdoi
10.1016/j.jpsychores.2012.10.007subject
Has Abstractpub_date
2013-04-01 00:00:00pages
296-300issue
4eissn
0022-3999issn
1879-1360pii
S0022-3999(12)00284-Xjournal_volume
74pub_type
杂志文章abstract：OBJECTIVE:Cannabis is a widely used substance that may be becoming more socially accepted, legally tolerated, and utilized by younger individuals. This review explores the relationship between cannabis and the onset of psychosis as well as the policy ramifications of current research. METHOD:This article synthesizes p...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
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abstract：OBJECTIVES:This study aimed to describe the psychological functioning of interstitial cystitis/bladder pain syndrome patients utilizing MMPI-2-RF scoring. METHODS:The MMPI-2 was administered to 60 individuals who reported a diagnosis of IC. Responses were scored in the MMPI-2-RF format. Fifty-one protocols were deemed...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Journal of psychosomatic research
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更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Tourette syndrome (TS) is a disorder of chronic motor and vocal tics that begins in childhood. METHODS:A systematic Medline search was conducted to identify existing anatomical imaging studies in persons with TS. RESULTS:Thirty studies were identified, and their methods and findings were reviewed. Findings...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2009.07.005
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:Previous research has indicated that the concealment of homosexuality is related to poorer health among gay men with HIV. This study explored mechanisms by which concealment of homosexuality may be related to HIV disease status by examining associations between concealment of homosexuality, social support, so...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(02)00481-6
更新日期：2003-03-01 00:00:00
abstract：:Chronic fatigue syndrome (CFS) is a poorly understood condition. Possible etiological factors include infectious agents, psychiatric disorders, and personality characteristics. We examined personality dimensions in 30 nondepressed patients with CFS, 20 patients with major depressive disorder (MDD), and 15 healthy cont...
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pub_type： 临床试验,杂志文章
doi：10.1016/s0022-3999(98)00120-2
更新日期：1999-04-01 00:00:00
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journal_title：Journal of psychosomatic research
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journal_title：Journal of psychosomatic research
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更新日期：2013-06-01 00:00:00
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更新日期：2003-05-01 00:00:00
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更新日期：2011-04-01 00:00:00
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更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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更新日期：2013-11-01 00:00:00
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更新日期：2015-12-01 00:00:00
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更新日期：2019-08-01 00:00:00
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journal_title：Journal of psychosomatic research
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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更新日期：2017-08-01 00:00:00
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更新日期：2015-09-01 00:00:00
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journal_title：Journal of psychosomatic research
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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更新日期：2011-04-01 00:00:00
