Abstract:
OBJECTIVE:To explore the association between depressive symptom history and cancer incidence. METHODS:Affective/emotional depressive symptoms were assessed using the General Health Questionnaire (GHQ-30) depression sub-scale across phase 1 (1985-1988), phase 2 (1989-1990), and phase 3 (1991-1994) of the Whitehall II prospective cohort study; 'chronic'=depressive episode at phase 1, 2 and 3; 'new'=depressive episode at phase 3 only. Cancer incidence was obtained from the National Health Service Central Register with an average follow-up of 15.6 years (range 0.08-17.4). The study sample consisted of 6983 participants, aged 35-55 years at baseline. Results were adjusted for age, sex, socio-economic position, health behaviours, health status/conditions, medication, and social support. RESULTS:Over a 17.4 year follow-up, chronic depressive symptoms did not increase the risk of cancer incidence compared to those who never experienced symptoms (hazard ratio (HR)=1.03, 95% confidence interval (CI): 0.71-1.49). Participants who experienced new depressive symptoms had an increased risk of cancer incidence in the first 9 years of follow-up (HR=1.89, 95% CI: 1.23-2.90) but no increased risk in later years (HR=0.84, 95% CI: 0.52-1.35). CONCLUSION:Chronic depressive symptoms were not associated with cancer incidence. In contrast, new-onset symptoms were associated with a substantially increased risk, possibly due to reverse causality.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Archer G,Pikhart H,Head Jdoi
10.1016/j.jpsychores.2015.07.011subject
Has Abstractpub_date
2015-12-01 00:00:00pages
595-603issue
6eissn
0022-3999issn
1879-1360pii
S0022-3999(15)00511-5journal_volume
79pub_type
杂志文章abstract:OBJECTIVE:Cardiac patients with psychological distress have a poorer prognosis than patients without distress; which may in part reflect differences in treatment. We quantified variation in coronary angiography and revascularisation procedures according to psychological distress among patients admitted with incident ac...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2019.109794
更新日期:2019-10-01 00:00:00
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journal_title:Journal of psychosomatic research
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journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-12-01 00:00:00
abstract::Chronic pelvic pain is a common gynecological problem. There has long been an assumption that social and psychological factors play a part in its genesis in a significant subgroup, but their precise role remains unclear. More recently, childhood sexual abuse has been implicated as a specific risk factor. For this revi...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
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journal_title:Journal of psychosomatic research
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更新日期:2020-01-28 00:00:00
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journal_title:Journal of psychosomatic research
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doi:10.1016/j.jpsychores.2006.12.003
更新日期:2007-06-01 00:00:00
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journal_title:Journal of psychosomatic research
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更新日期:2005-07-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(94)00139-v
更新日期:1995-04-01 00:00:00
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journal_title:Journal of psychosomatic research
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更新日期:2000-08-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-01-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(91)90082-y
更新日期:1991-01-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(00)00179-3
更新日期:2000-11-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
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更新日期:2020-01-23 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2006.07.028
更新日期:2007-01-01 00:00:00
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jpsychores.2018.11.016
更新日期:2019-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2004-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-02-01 00:00:00
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更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(97)00207-9
更新日期:1998-02-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(98)00003-8
更新日期:1998-10-01 00:00:00
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journal_title:Journal of psychosomatic research
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00