Abstract：
:We investigated if response to the fenfluramine challenge test could predict outcome in 47 nonpsychiatric patients with chronic functional gastrointestinal disorder (FGD) treated with mianserin, a drug closely related to mirtazepine, or placebo. Sixty milligrams of fenfluramine was given orally in the morning on nonfasting basis. Serum cortisol (COR) and prolactin (PRL) were analyzed at baseline, and after 120, 180, and 240 minutes. Patients were then randomized into a 7-week double-blind treatment trial with mianserin or placebo. Response to treatment with mianserin (76% vs.18% for placebo) was closely linked to a high increase in PRL and COR following a fenfluramine challenge test (positive predictive power=72%). Adding length of illness history increased both positive and negative predictive power to 92%. Our results indicate that the fenfluramine challenge test may be a potentially useful tool to identify nonpsychiatric subjects with FGD, who will most likely respond to treatment with a combined alpha2 and 5HT-2 and -3 antagonist.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Tanum L,Bråtveit-Johansen K,Malt UFdoi
10.1016/s0022-3999(99)00053-7subject
Has Abstractpub_date
1999-12-01 00:00:00pages
525-35issue
6eissn
0022-3999issn
1879-1360pii
S0022399999000537journal_volume
47pub_type
临床试验,杂志文章,随机对照试验abstract：OBJECTIVE:To develop and validate a brief screening tool for predicting functional somatic symptoms (FSS) based on clinical and non-clinical information from the general practitioner referral letter, and to assess its inter-rater reliability. METHODS:The derivation sample consisted of 357 consecutive patients referred...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.10.004
更新日期：2014-12-01 00:00:00
abstract：:This review examines the literature on psychological reactions, often referred to as 'compensation neurosis', which occur after an accident and which are thought to be produced or maintained by a compensation claim. Theories and research are examined. The area is complicated and research so far is limited in scope and...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/0022-3999(83)90085-5
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:There are many similarities between chronic fatigue syndrome (CFS), the somatoform disorders and problems otherwise known as "medically unexplained symptoms." There is some evidence to suggest that a combination of inadequate parenting and early illness experience may predispose the individual to develop medi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(02)00458-0
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:The present study examined (1) mean-level differences in self-esteem and Big Five personality traits between individuals with and without diabetes; and (2) demographic, clinical, and psychological correlates of patients' self-esteem and Big Five. RESEARCH DESIGN AND METHODS:A total of 478 emerging adults wit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2013.11.015
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:To perform a quantitative evaluation of Hoover's test using a simple device--routine weighing scales. To determine a cut-off value of a Hoover's index, and to analyze the behavior of Hoover's test in "painful paresis". METHODS:The subjects were 9 patients presenting with psychogenic paresis of one leg, 9 wi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.10.004
更新日期：2013-04-01 00:00:00
abstract：:Blood pressure and heart rate responses were monitored while 30 medical, dental or graduate students completed four laboratory tasks. On a second day, subjects wore an ambulatory blood pressure monitor, and during this day they completed the real-world challenge of presenting their research in front of a small audienc...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(90)90033-z
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:Qualitative evidence suggests that personality may have special relevance to the predisposition, precipitation and perpetuation of chronic fatigue syndrome (CFS). This study compares three dimensions of personality - perfectionism, self-esteem, and emotional control in the personality profiles of CFS patient...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(00)00087-8
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to examine whether mental vulnerability is a risk factor for the development of ischemic heart disease (IHD) after adjustment for well-established risk factors. METHODS:In three prospective cohort studies in Copenhagen County, Denmark, we recorded the level of mental vulnerabilit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2005.05.013
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:Fear of progression (FoP) is a frequent symptom among cancer patients, but data among hematological cancer survivors are scarce. Furthermore, theory assumes that FoP serves as link between bodily symptoms and different aspects of quality of life. However, this model has not been tested with the bodily symptom...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.109844
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:Interventions for fear of recurrence (FOR) of cancer have nominal effects, perhaps due to limited integration of empirically supported skills. This pilot trial tested the acceptability and feasibility of a multimodal, mind-body resiliency intervention targeting FOR among survivors of various cancers. METHODS...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2020.110215
更新日期：2020-08-10 00:00:00
abstract：OBJECTIVE:Type D personality is a psychosocial risk factor for cardiovascular events and in-stent restenosis (ISR), but the mechanisms involved are not well understood. This study aimed to evaluate the effects of dietary patterns on the association between Type D personality and ISR in patients with coronary artery dis...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2020.110244
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:Little work has investigated the relationship between unfairness and risk factors for heart disease. We examine the role of unfairness in predicting the metabolic syndrome and explaining the social gradient of the metabolic syndrome. METHODS:The design is a prospective study with an average follow-up of 5.8...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2007.04.006
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:In the past decade, a few studies have suggested that psoriasis could be associated with the presence of mild cognitive deficits. OBJECTIVES:The aim of the present matched case-control study was to investigate several cognitive domains (executive functions, verbal memory, attention, and language) in a sampl...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2017.12.011
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To explore the effect of perceived stress and coping behaviors on quality of life and clinical outcomes in patients with ulcerative colitis. METHODS:This is a prospective cohort study in a tertiary inflammatory bowel disease center in China. A total of 263 ulcerative colitis patients were enrolled consecutiv...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.07.013
更新日期：2018-10-01 00:00:00
abstract：:Thirty pregnant women with raised serum alpha fetoprotein (AFP) were interviewed before and after they received real-time ultrasound scanning to further diagnose fetal abnormalities. Thirty pregnant mothers receiving routine ultrasound scanning for dates served as the controls. The 'at risk' group were more anxious an...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(87)90095-x
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:Adult attachment has been suggested to mediate the effect of social support on stress protection. The purpose of this study was to investigate the effects of adult attachment and social support on psychological and endocrine responses to psychosocial stress. METHODS:Sixty-three healthy men who were married o...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychores.2007.11.011
更新日期：2008-05-01 00:00:00
abstract：:The cardiovascular fitness, blood pressure, resting pulse, lung capacity and body fat of 246 subjects were measured and each subject completed activity, mental health and mood questionnaires. The results of this study support the hypothesis that participation in physical activity, rather than cardiovascular fitness, i...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(92)90055-7
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to evaluate electronic diaries as a tool for investigating associations between physical symptoms and psychological variables. METHODS:A qualitative systematic review of electronic diary studies in pain and symptoms research was performed. RESULTS:Studies of electronic diary ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2006.12.022
更新日期：2007-05-01 00:00:00
abstract：:Disturbances of sleep are a hallmark of seasonal affective disorders (SAD), as they are of other mood disorders. Fall/winter SAD patients most often report hypersomnia. Among responses of 293 SAD patients on a symptom questionnaire, complaints of winter hypersomnia (80%) greatly exceeded insomnia (10%), hypersomnia pl...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(94)90037-x
更新日期：1994-05-01 00:00:00
abstract：:The McGill Pain Questionnaire (MPQ) was administered to 268 subjects following electrical stimulation to pain-tolerance limits. Subjects received stimulation under four social modeling conditions: tolerant, intolerant, control, and no model. The number of factors and degree of obliqueness most appropriate for the MPQ ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(86)90085-1
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVES:Patients with HIV infection frequently complain of sleep disturbances and daytime sleepiness. Only few data on these problems evaluated by standardized measures is available. METHODS:A sample of 180 consecutive patients with HIV infection referred to the internal and to the neurological HIV clinics at the U...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.03.003
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:The Training and Support Program (TSP) was designed to equip parents of children with disabilities with a simple massage skill for use with their children in the home environment. The effectiveness of the TSP was examined in a randomized controlled trial with a wait-list control group. METHODS:Parents were t...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jpsychores.2007.06.006
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Depression, one of the most prevalent and disabling disorders in Europe, is thought to be associated with unhealthy eating styles. As prevalence of depression and eating styles potentially differ across Europe, the current study aimed to investigate in a large, European sample, the associations of history of ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.03.003
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To examine the association of diabetes and prediabetes with suicide deaths in a Japanese working population. METHODS:A nested case-control study was conducted using data from the Japan Epidemiology Collaboration on Occupational Health Study. During 8 years of follow-up, we identified 56 registered cases of s...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2020.110246
更新日期：2020-11-01 00:00:00
abstract：:The EEG photic driving response is a sensitive neurophysiological measure. It has been used to assess drug effects, forms of epilepsy, neurological status of Alzheimer's patients, and physiological arousal. Photic driving also impacts the psychological status of a person by producing increased visual imagery and decre...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00204-3
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:With the increasing prevalence of multiple conditions in older age, the high prevalence of mental disorders, and the many social challenges facing elderly people, a high-risk patient group in need of interdisciplinary (biological, psychological, and social) care is emerging. The INTERMED interview is an integ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.09.003
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:Two studies were conducted to assess the construct validity of the Symptom Interpretation Questionnaire (SIQ) with particular attention to its relationship to social desirability, daily symptom, mood, hassles reports, and personality. METHODS:Participants completed a battery of self-report measures collected...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2006.07.006
更新日期：2006-12-01 00:00:00
abstract：:Two very different assumptions about the principles of blood pressure reactivity lead to quite different notions about hypertensive/normotensive behaviour. Both are referred to as the Law of Initial Value (LIV). Subsequent confusion about blood pressure reactivity vs resting level partly explains a number of inconsist...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(88)90053-0
更新日期：1988-01-01 00:00:00
abstract：:This cross-sectional study reveals that a significant proportion (35%) of the sampled population of factory workers experienced measurable health problems in the form of anxiety, sleep disturbance, depression, somatic complaints and other clinical indicators of stress. Job stress and social support levels experienced ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(91)90071-u
更新日期：1991-01-01 00:00:00
abstract：:Despite that burnout presents a serious burden for modern society, there are no diagnostic criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there is a need to dispose of a burnout biomarker. Epigenetic studies suggest that DNA methylation is a possible mediator linking indiv...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2016.11.005
更新日期：2017-01-01 00:00:00
